7250-70-6

Basic information

• Product Name: N-(2-Methylphenyl)piperidine
• Synonyms: N-(2-Methylphenyl)piperidine
• CAS NO: 7250-70-6
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.2701
• Mol File: 7250-70-6.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 274.8°Cat760mmHg
• Flash Point: 109.7°C
• Appearance: /
• Density: 0.984g/cm³
• Vapor Pressure: 0.0053mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: N-(2-Methylphenyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Methylphenyl)piperidine(7250-70-6)
• EPA Substance Registry System: N-(2-Methylphenyl)piperidine(7250-70-6)

Safety Data

• Hazardous Substances Data: 7250-70-6(Hazardous Substances Data)

Usage

General Description

N-(2-Methylphenyl)piperidine, also known as N-Methyl-2-phenylpiperidine, is a chemical compound with the molecular formula C13H17N. It is a piperidine derivative with a methylphenyl group attached to the nitrogen atom. N-(2-Methylphenyl)piperidine is commonly used in the synthesis of pharmaceutical compounds, particularly in the development of new drugs for various medical purposes. It has also been studied for its potential psychoactive effects, although its exact mechanism of action and potential uses in this regard are not fully understood. N-(2-Methylphenyl)piperidine is considered to have minimal toxicity and is generally stable under normal conditions, making it a useful compound for research and development in the pharmaceutical industry.

InChI:InChI=1/C12H17N/c1-11-7-3-4-8-12(11)13-9-5-2-6-10-13/h3-4,7-8H,2,5-6,9-10H2,1H3

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 5542-49-4 piperidin-1-yl benzoate 
• 110-89-4 piperidine 
• 3991-61-5 1-methyl-2-phenoxybenzene 
• 2156-71-0 N-chloropiperidine 
• 108-88-3 toluene 
• 352-70-5 m-Fluorotoluene 
• 195062-59-0 2-methylphenylboronic acid pinacol ester 
• 766-09-6 1-ethyl-piperidine 
• 95-46-5 2-methylphenyl bromide 
• 95-49-8 2-methylchlorobenzene 
• 615-37-2 ortho-methylphenyl iodide 
• 7029-31-4 bis(2-methylphenyl)zinc 
• 111-29-5 1 ,5-pentanediol 

Downstream Products

• 60815-16-9 2-(o-formylphenyl)-1-phenylethanone 
• 1260154-54-8 C₁₉H₁₉NO₂ 

Relevant articles and documents

Synthesis of N-heterocyclic carbene-Pd(II)-5-phenyloxazole complexes and initial studies of their catalytic activity toward the Buchwald-Hartwig amination of aryl chlorides

Three new N-heterocyclic carbene (NHC)-Pd(II) complexes using 5-phenyloxazole as the ancillary ligand have been obtained in moderate to good yields by a one-pot reaction of the corresponding imidazolium salts, palladium chloride and 5-phenyloxazole under mild conditions. Initial studies showed that one of the complexes is an efficient catalyst for the Buchwald-Hartwig amination of aryl chlorides with various secondary and primary amines under the varied catalyst loading of 0.01-0.05 mol%, thus it will enrich the chemistry of NHCs and give an alternative catalyst for the coupling of challenging while cost-low aryl chlorides.

Electron Donor-Acceptor Complex-Initiated Photochemical Cyanation for the Preparation of α-Amino Nitriles

An electron donor-acceptor complex-initiated α-cyanation of tertiary amines has been described. The reaction protocol provides a novel method to synthesize various α-amino nitriles under mild conditions. The reaction can proceed smoothly without the presence of photocatalysts and transition metal catalysts, and either oxidants are unnecessary or O2 is the only oxidant. The practicality of this method is showcased not only by the late-stage functionalization of natural alkaloid derivatives and pharmaceutical intermediate, but also by the applicability of a stop-flow microtubing reactor.

N-Heterocyclic carbene-palladacyclic complexes: synthesis, characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01 mol%).