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Cas Database

7255-58-5

7255-58-5

Identification

  • Product Name:diethyl 2-[[(2-nitrophenyl)amino]methylidene]propanedioate

  • CAS Number: 7255-58-5

  • EINECS:

  • Molecular Weight:308.291

  • Molecular Formula: C14H16N2O6

  • HS Code:

  • Mol File:7255-58-5.mol

Synonyms:GNF-Pf-3211;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:ChemScene
  • Product Description:diethyl2-((2-nitrophenylamino)methylene)malonate
  • Packaging:1g
  • Price:$ 352
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 8 Articles be found

Insights into supramolecular assembly formation of diethyl aryl amino methylene malonate (DAM)derivatives assisted via non-covalent interactions

Shaik, Althaf,Angira, Deekshi,Thiruvenkatam, Vijay

, p. 178 - 185 (2019/05/14)

The crystal structures of four derivatives of diethyl 2-(((aryl)amino)methylene)malonate (DAM)have been studied by single crystal X-ray diffraction. The molecular structures of all the four derivatives were found to be in co-planar conformation. The detailed analysis of molecular conformation in four derivatives reveals the presence of a common strong intramolecular N–H?O hydrogen bonding, forming a ring of graph-set motif S1 1 (6). The effect of chloro and nitro substitution on their relative strengths of hydrogen bonding are analyzed here. Particularly, in compound 1, additional intramolecular hydrogen bonding between –NO2 and N–H was observed that results in the formation of another six-membered chelate ring. On the other hand in case of compound 3, we have observed type-I Cl?Cl interaction for the first time in this class of compounds. Further, Hirshfeld surface has been generated that is mapped with dnorm shape index and curvedness to summarize the weak interactions and examine the molecular shapes in all four derivatives. Effect of nitro (1 and 2)and chloro (3 and 4)substitution on the C?H, N?O and C?O interaction is highlighted in molecular contour and 2D fingerprint plots.

Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice

Pasquini, Serena,De Rosa, Maria,Pedani, Valentina,Mugnaini, Claudia,Guida, Francesca,Luongo, Livio,De Chiaro, Maria,Maione, Sabatino,Dragoni, Stefania,Frosini, Maria,Ligresti, Alessia,Di Marzo, Vincenzo,Corelli, Federico

supporting information; experimental part, p. 5444 - 5453 (2011/09/30)

Experimental evidence suggests that selective CB2 receptor modulators may provide access to antihyperalgesic agents devoid of psychotropic effects. Taking advantage of previous findings on structure-activity/selectivity relationships for a class of 4-quin

QUINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PREPARATION PROCESS FOR THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

-

Page/Page column 88-90, (2008/12/07)

Provided is a quinoline derivative represented by the following Formula (1) for use in treating a caspase- mediated disease by inhibition of caspase-3 activity. Further provided are a method for preparing the quinoline derivative or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing the same.

4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS

-

Page/Page column 59, (2010/02/13)

The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.

QUINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PREPARATION FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

-

Page/Page column 26-27, (2008/06/13)

The present invention relates to new quinoline derivatives of formula (1) or their pharmaceutically acceptable salts with caspase-3 inhibitory activity and their preparation methods, wherein R2 is H; halogen; C1-6alkyl; C 1-6 alkoxy; C1-6 alkoxyalkyl; or C3-6cycloalkyl; R1 is formula (a); -CN; or formula (b); R is H; C6-14aryl unsubstituted or substituted by halogen, C1-6 alkyl, C1-6 alkoxy or amino; 5 - 15 membered heterocyclic group unsubstituted or substituted by halogen, C1-6 alkyl, C1-6 alkoxy or amino; or -(CH2)n-CHR4R5. The present invention relates to a pharmaceutical composition for treating caspase-associated diseases by inhibiting the activity of caspase-3 which comprises the compound of formula (1) or its pharmaceutically acceptable salt.

Process route upstream and downstream products

Process route

2-nitro-aniline
88-74-4

2-nitro-aniline

diethyl 2-ethoxymethylenemalonate
87-13-8

diethyl 2-ethoxymethylenemalonate

ethanol
64-17-5

ethanol

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester
7255-58-5

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester

Conditions
Conditions Yield
at 130 ℃; for 2h;
2-nitro-aniline
88-74-4

2-nitro-aniline

diethyl 2-ethoxymethylenemalonate
87-13-8

diethyl 2-ethoxymethylenemalonate

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester
7255-58-5

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester

Conditions
Conditions Yield
In toluene; at 150 ℃; for 3h; Sealed tube;
92%
In ethanol; at 120 ℃; for 6h; Heating / reflux;
69%
In ethanol; at 120 ℃; for 6h;
69%
at 120 ℃; for 2h; Inert atmosphere;
67%
In various solvent(s); for 2.5h; Heating;
43%
8-(N-butyl-N-ethylcarbamoyl)-3-ethoxycarbonyl-4-oxo-3,4-dihydro-1,10-phenanthroline

8-(N-butyl-N-ethylcarbamoyl)-3-ethoxycarbonyl-4-oxo-3,4-dihydro-1,10-phenanthroline

2-nitro-aniline
88-74-4

2-nitro-aniline

diethyl 2-ethoxymethylenemalonate
87-13-8

diethyl 2-ethoxymethylenemalonate

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester
7255-58-5

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester

Conditions
Conditions Yield
In ethanol;
88%
In ethanol;
88%
2-nitro-aniline
88-74-4

2-nitro-aniline

diethyl 2-ethoxymethylenemalonate
87-13-8

diethyl 2-ethoxymethylenemalonate

ethanol
64-17-5

ethanol

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester
7255-58-5

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester

Conditions
Conditions Yield
at 130 ℃; for 2h;
2-nitro-aniline
88-74-4

2-nitro-aniline

diethyl 2-ethoxymethylenemalonate
87-13-8

diethyl 2-ethoxymethylenemalonate

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester
7255-58-5

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester

Conditions
Conditions Yield
In toluene; at 150 ℃; for 3h; Sealed tube;
92%
In ethanol; at 120 ℃; for 6h; Heating / reflux;
69%
In ethanol; at 120 ℃; for 6h;
69%
at 120 ℃; for 2h; Inert atmosphere;
67%
In various solvent(s); for 2.5h; Heating;
43%
8-(N-butyl-N-ethylcarbamoyl)-3-ethoxycarbonyl-4-oxo-3,4-dihydro-1,10-phenanthroline

8-(N-butyl-N-ethylcarbamoyl)-3-ethoxycarbonyl-4-oxo-3,4-dihydro-1,10-phenanthroline

2-nitro-aniline
88-74-4

2-nitro-aniline

diethyl 2-ethoxymethylenemalonate
87-13-8

diethyl 2-ethoxymethylenemalonate

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester
7255-58-5

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester

Conditions
Conditions Yield
In ethanol;
88%
In ethanol;
88%

Global suppliers and manufacturers

Global( 4) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Hangzhou Dingyan Chem Co., Ltd
  • Business Type:Manufacturers
  • Contact Tel:86-571-86465881,86-571-87157530,86-571-88025800
  • Emails:sales@dingyanchem.com
  • Main Products:95
  • Country:China (Mainland)
  • GZ HONESTCHEM CO., LTD
  • Business Type:Trading Company
  • Contact Tel:+8615013270415
  • Emails:1415961510@qq.com
  • Main Products:69
  • Country:China (Mainland)
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