72752-54-6

Basic information

• Product Name: 2-PIPERIDINOBENZYLAMINE
• Synonyms: ART-CHEM-BB B022095;BUTTPARK 95\50-95;AKOS B022095;2-PIPERIDINOBENZYLAMINE;RARECHEM AL BW 0505;2-Piperidin-1-ylbenzylamine;2-(1-Piperidinyl)Benzenemethanamine;BenzeneMethanaMine, 2-(1-piperidinyl)-
• CAS NO: 72752-54-6
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28
• Mol File: 72752-54-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 329.5°C at 760 mmHg
• Flash Point: 135.8°C
• Appearance: /
• Density: 1.047g/cm³
• Vapor Pressure: 0.000177mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Store under an inert atmosphere
• CAS DataBase Reference: 2-PIPERIDINOBENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PIPERIDINOBENZYLAMINE(72752-54-6)
• EPA Substance Registry System: 2-PIPERIDINOBENZYLAMINE(72752-54-6)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 72752-54-6(Hazardous Substances Data)

Usage

General Description

2-PIPERIDINOBENZYLAMINE is an organic chemical compound that belongs to the class of aromatic amines. It is a derivative of benzylamine, with a piperidine ring attached to the benzyl group. 2-PIPERIDINOBENZYLAMINE has been widely used in organic synthesis as a building block for the preparation of various biologically active molecules and pharmaceuticals. It is also known for its potential as a precursor for the synthesis of various derivatives with pharmacological properties. Additionally, 2-PIPERIDINOBENZYLAMINE has been studied for its potential use in medicinal chemistry and drug development due to its structural features and potential biological activities.

InChI:InChI=1/C12H18N2/c13-10-11-6-2-3-7-12(11)14-8-4-1-5-9-14/h2-3,6-7H,1,4-5,8-10,13H2

Upstream product

• 873-32-5 2-Chlorobenzonitrile 
• 110-89-4 piperidine 
• 394-47-8 2-fluorobenzonitrile 
• 72752-52-4 2-(piperidin-1-yl)benzonitrile 

Downstream Products

• 1028336-81-3 4-chloro-6-(2-piperidin-1-yl-benzylamino)-2H-phthalazin-1-one 
• 1258268-89-1 C₂₄H₂₄ClN₃O 
• 219922-30-2 ethyl 2-ethoxy-4-<2-<<2-cycloheptyl-1-<2-(1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate 
• 219922-29-9 ethyl 2-ethoxy-4-<2-<<2-cyclopentyl-1-<2-(1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate 
• 1026685-39-1 [2-Cycloheptyl-1-(2-piperidin-1-yl-phenyl)-ethyl]-[1-(2-piperidin-1-yl-phenyl)-meth-(E)-ylidene]-amine 
• 219922-28-8 ethyl 2-ethoxy-4-<2-<<2-cyclobutyl-1-<2-(1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate 
• 219922-27-7 ethyl 2-ethoxy-4-<2-<<2-cyclopropyl-1-<2-(1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate 
• 219922-24-4 ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>3-buten-1-yl>amino>-2-oxoethyl>-benzoate 

Relevant articles and documents

Aminoborohydrides. 12. Novel tandem SNAr amination-reduction reactions of 2-halobenzonitriles with lithium N,N-dialkylaminoborohydrides

A novel tandem amination-reduction reaction has been developed in which 2-(N,N-dialkylamino)benzylamines are generated from 2-halobenzonitriles and lithium N,N-dialkylaminoborohydride (LAB) reagents. These reactions are believed to occur through a tandem SNAr amination-reduction mechanism wherein the LAB reagent promotes halide displacement by the N,N-dialkylamino group, and the nitrile is subsequently reduced. This one-pot procedure is complimentary to existing synthetic methods and is an attractive synthetic tool for the nucleophilic aromatic substitution of halobenzenes with less nucleophilic amines. The (N,N-dialkylamino)benzylamine products of this reaction are easily isolated after a simple aqueous workup procedure in very good to excellent yields.