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Cas Database

72956-44-6

72956-44-6

Identification

  • Product Name:Phenol,2-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-

  • CAS Number: 72956-44-6

  • EINECS:

  • Molecular Weight:392.4477

  • Molecular Formula: C23H24 N2 O4

  • HS Code:

  • Mol File:72956-44-6.mol

Synonyms:BM 14242;Desmethylcarvedilol

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:Usbiological
  • Product Description:O-Desmethylcarvedilol
  • Packaging:5mg
  • Price:$ 460
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:O-DesmethylCarvedilol
  • Packaging:50mg
  • Price:$ 1455
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:O-DesmethylCarvedilol
  • Packaging:5 mg
  • Price:$ 870
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:O-Desmethyl carvedilol
  • Packaging:25 mg
  • Price:$ 721
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:O-Desmethyl carvedilol
  • Packaging:10 mg
  • Price:$ 396.5
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:O-Desmethyl carvedilol
  • Packaging:50 mg
  • Price:$ 1310.5
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:O-Desmethyl carvedilol
  • Packaging:2 mg
  • Price:$ 120
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:ORTHO-DESMETHYL CARVEDILOL 95.00%
  • Packaging:50MG
  • Price:$ 1686.3
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:ORTHO-DESMETHYL CARVEDILOL 95.00%
  • Packaging:5MG
  • Price:$ 345.4
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Relevant articles and documentsAll total 2 Articles be found

STORE OVERLOAD-INDUCED CALCIUM RELEASE INHIBITORS AND METHODS FOR PRODUCING AND USING THE SAME

-

Sheet 1/7, (2015/03/16)

The present invention provides compounds having store overload-induced Ca2+ release (SOICR) inhibitory activity and methods for producing and using the same. In particular, compounds of the invention is of the formula: R1-X1-L-X2-R2, wherein R1, X1, L, X2, and R2 are those defined herein.

Novel carvedilol analogues that suppress store-overload-induced Ca 2+ release

Smith, Chris D.,Wang, Aixia,Vembaiyan, Kannan,Zhang, Jingqun,Xie, Cuihong,Zhou, Qiang,Wu, Guogen,Chen, S. R. Wayne,Back, Thomas G.

, p. 8626 - 8655 (2013/12/04)

Carvedilol is a uniquely effective drug for the treatment of cardiac arrhythmias in patients with heart failure. This activity is in part because of its ability to inhibit store-overload-induced calcium release (SOICR) through the RyR2 channel. We describe the synthesis, characterization, and bioassay of ca. 100 compounds based on the carvedilol motif to identify features that correlate with and optimize SOICR inhibition. A single-cell bioassay was employed on the basis of the RyR2-R4496C mutant HEK-293 cell line in which calcium release from the endoplasmic reticulum through the defective channel was measured. IC50 values for SOICR inhibition were thus obtained. The compounds investigated contained modifications to the three principal subunits of carvedilol, including the carbazole and catechol moieties, as well as the linker chain containing the β-amino alcohol functionality. The SAR results indicate that significant alterations are tolerated in each of the three subunits.

Process route upstream and downstream products

Process route

5-[(9H-carbazol-4-yloxy)methyl]-3-[2-(2-hydroxyphenoxy)ethyl]-2-oxazolidinone
1479049-26-7

5-[(9H-carbazol-4-yloxy)methyl]-3-[2-(2-hydroxyphenoxy)ethyl]-2-oxazolidinone

Conditions
Conditions Yield
With sodium hydroxide; In ethanol; Reflux;
78%
With ethanol; sodium hydroxide; Reflux;
5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one
180987-80-8

5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: boron tribromide / dichloromethane / 20 °C
2: sodium hydroxide / ethanol / Reflux
With boron tribromide; sodium hydroxide; In ethanol; dichloromethane;
Multi-step reaction with 2 steps
1: boron tribromide / dichloromethane / 20 °C
2: sodium hydroxide; ethanol / Reflux
With ethanol; boron tribromide; sodium hydroxide; In dichloromethane;
4-(2,3-epoxypropoxy)carbazole
51997-51-4,95093-96-2

4-(2,3-epoxypropoxy)carbazole

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: isopropyl alcohol / 2 h / Reflux
2: triethylamine / dichloromethane / 5 h / 20 °C
3: boron tribromide / dichloromethane / 20 °C
4: sodium hydroxide / ethanol / Reflux
With boron tribromide; triethylamine; sodium hydroxide; In ethanol; dichloromethane; isopropyl alcohol;
Multi-step reaction with 4 steps
1: lithium bromide
2: triethylamine / dichloromethane / 20 °C
3: boron tribromide / dichloromethane / 20 °C
4: sodium hydroxide; ethanol / Reflux
With ethanol; boron tribromide; triethylamine; lithium bromide; sodium hydroxide; In dichloromethane;
2-(2-methoxy-phenoxy)-ethylamine
1836-62-0

2-(2-methoxy-phenoxy)-ethylamine

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: isopropyl alcohol / 2 h / Reflux
2: triethylamine / dichloromethane / 5 h / 20 °C
3: boron tribromide / dichloromethane / 20 °C
4: sodium hydroxide / ethanol / Reflux
With boron tribromide; triethylamine; sodium hydroxide; In ethanol; dichloromethane; isopropyl alcohol;
Multi-step reaction with 4 steps
1: lithium bromide
2: triethylamine / dichloromethane / 20 °C
3: boron tribromide / dichloromethane / 20 °C
4: sodium hydroxide; ethanol / Reflux
With ethanol; boron tribromide; triethylamine; lithium bromide; sodium hydroxide; In dichloromethane;
carvedilol
72956-09-3

carvedilol

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 5 h / 20 °C
2: boron tribromide / dichloromethane / 20 °C
3: sodium hydroxide / ethanol / Reflux
With boron tribromide; triethylamine; sodium hydroxide; In ethanol; dichloromethane;
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 20 °C
2: boron tribromide / dichloromethane / 20 °C
3: sodium hydroxide; ethanol / Reflux
With ethanol; boron tribromide; triethylamine; sodium hydroxide; In dichloromethane;
Conditions
Conditions Yield
/BRN= 517518/, Pd/C, Hydrogenolyse;
5-[(9H-carbazol-4-yloxy)methyl]-3-[2-(2-hydroxyphenoxy)ethyl]-2-oxazolidinone
1479049-26-7

5-[(9H-carbazol-4-yloxy)methyl]-3-[2-(2-hydroxyphenoxy)ethyl]-2-oxazolidinone

Conditions
Conditions Yield
With sodium hydroxide; In ethanol; Reflux;
78%
With ethanol; sodium hydroxide; Reflux;
5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one
180987-80-8

5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: boron tribromide / dichloromethane / 20 °C
2: sodium hydroxide / ethanol / Reflux
With boron tribromide; sodium hydroxide; In ethanol; dichloromethane;
Multi-step reaction with 2 steps
1: boron tribromide / dichloromethane / 20 °C
2: sodium hydroxide; ethanol / Reflux
With ethanol; boron tribromide; sodium hydroxide; In dichloromethane;
4-(2,3-epoxypropoxy)carbazole
51997-51-4,95093-96-2

4-(2,3-epoxypropoxy)carbazole

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: isopropyl alcohol / 2 h / Reflux
2: triethylamine / dichloromethane / 5 h / 20 °C
3: boron tribromide / dichloromethane / 20 °C
4: sodium hydroxide / ethanol / Reflux
With boron tribromide; triethylamine; sodium hydroxide; In ethanol; dichloromethane; isopropyl alcohol;
Multi-step reaction with 4 steps
1: lithium bromide
2: triethylamine / dichloromethane / 20 °C
3: boron tribromide / dichloromethane / 20 °C
4: sodium hydroxide; ethanol / Reflux
With ethanol; boron tribromide; triethylamine; lithium bromide; sodium hydroxide; In dichloromethane;
2-(2-methoxy-phenoxy)-ethylamine
1836-62-0

2-(2-methoxy-phenoxy)-ethylamine

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: isopropyl alcohol / 2 h / Reflux
2: triethylamine / dichloromethane / 5 h / 20 °C
3: boron tribromide / dichloromethane / 20 °C
4: sodium hydroxide / ethanol / Reflux
With boron tribromide; triethylamine; sodium hydroxide; In ethanol; dichloromethane; isopropyl alcohol;
Multi-step reaction with 4 steps
1: lithium bromide
2: triethylamine / dichloromethane / 20 °C
3: boron tribromide / dichloromethane / 20 °C
4: sodium hydroxide; ethanol / Reflux
With ethanol; boron tribromide; triethylamine; lithium bromide; sodium hydroxide; In dichloromethane;

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  • Career Henan Chemical Co
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  • Finetech Industry Limited
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  • NovaChemistry
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  • SynFine Research, Inc.
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