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Cas Database

7298-67-1

7298-67-1

Identification

  • Product Name:N-(3-Acetyl-4-hydroxy-phenyl)acetamide

  • CAS Number: 7298-67-1

  • EINECS:230-735-4

  • Molecular Weight:193.202

  • Molecular Formula: C10H11NO3

  • HS Code:2924299090

  • Mol File:7298-67-1.mol

Synonyms:N-(3-Acetyl-4-hydroxyphenyl)acetamide;N1-(3-Acetyl-4-hydroxyphenyl)acetamide;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi,Xn

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowedH315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:TRC
  • Product Description:N-(3-Acetyl-4-hydroxyphenyl)acetamide
  • Packaging:100mg
  • Price:$ 45
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:N-(3-Acetyl-4-hydroxyphenyl)acetamide
  • Packaging:250mg
  • Price:$ 55
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  • Manufacture/Brand:TCI Chemical
  • Product Description:5'-Acetamido-2'-hydroxyacetophenone >98.0%(HPLC)(T)
  • Packaging:1g
  • Price:$ 62
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  • Manufacture/Brand:TCI Chemical
  • Product Description:5'-Acetamido-2'-hydroxyacetophenone >98.0%(HPLC)(T)
  • Packaging:5g
  • Price:$ 208
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:N1-(3-Acetyl-4-hydroxyphenyl)acetamide
  • Packaging:250 mg
  • Price:$ 192
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:N1-(3-Acetyl-4-hydroxyphenyl)acetamide
  • Packaging:1 g
  • Price:$ 320
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:N1-(3-Acetyl-4-hydroxyphenyl)acetamide
  • Packaging:100 mg
  • Price:$ 96
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:N-(3-Acetyl-4-hydroxyphenyl)acetamide 97%
  • Packaging:5g
  • Price:$ 342
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:N-(3-Acetyl-4-hydroxyphenyl)acetamide 97%
  • Packaging:1g
  • Price:$ 94
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  • Manufacture/Brand:Atlantic Research Chemicals
  • Product Description:N-(3-Acetyl-4-hydroxyphenyl)acetamide 95%
  • Packaging:5gm:
  • Price:$ 35.35
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Relevant articles and documentsAll total 37 Articles be found

Method for diacetate intermediate 5 - acetamide group -2 - (2, 3 - epoxypropoxy) acetophenone

-

Paragraph 0022; 0026-0027; 0029-0030; 0032-0033; 0035-0036.., (2021/11/14)

The invention belongs to the field of organic photochemical and drug intermediate chemistry. The invention particularly relates to a method for synthesizing diacetate intermediate - acetamide group 5 - (-2 - 2 epoxypropoxy) acetophenone containing acetylated 3 - photochemical rearrangement reaction in series. The reactant is cooled to the polar organic solvent, Fries rearrangement is carried out directly by ultraviolet - visible light irradiation with specific wavelength, and the intermediate Fries acetyl 2 -4 - acetyl aminophenol is obtained by heating and evaporating the solvent after the reaction is finished. Sodium hydroxide was added to prepare the phenol salt. Then, an intermediate 5 - acetamide group -2 - (2, 3 - epoxypropoxy) acetophenone was obtained by reaction with epichlorohydrin. The tandem type synthesis method disclosed by the invention is simple and feasible, and low-toxicity, high-efficiency and cheap green chemical reagents are used in the synthesis process.

Redox-Neutral Selenium-Catalysed Isomerisation of para-Hydroxamic Acids into para-Aminophenols

Chuang, Hsiang-Yu,Schupp, Manuel,Meyrelles, Ricardo,Maryasin, Boris,Maulide, Nuno

, p. 13778 - 13782 (2021/03/31)

A selenium-catalysed para-hydroxylation of N-aryl-hydroxamic acids is reported. Mechanistically, the reaction comprises an N?O bond cleavage and consecutive selenium-induced [2,3]-rearrangement to deliver para-hydroxyaniline derivatives. The mechanism is studied through both 18O-crossover experiments as well as quantum chemical calculations. This redox-neutral transformation provides an unconventional synthetic approach to para-aminophenols.

Click chemistry synthesis, biological evaluation and docking study of some novel 2′-hydroxychalcone-triazole hybrids as potent anti-inflammatory agents

Abdu-Allah, Hajjaj H. M.,Boshra, Andrew N.,Hayallah, Alaa M.,Mohammed, Anber F.

, (2020/01/06)

A hybrid pharmacophore approach is used to design and synthesize two novel series of 2′-hydroxychalcone-triazole hybrid molecules 6a-j and 8a-j. These compounds were fully characterized by spectral and elemental analyses. They were evaluated in vitro and in vivo for anti-inflammatory activity. Most of compounds were selective inhibitors for COX-2. Among them, compounds 6d, 6f, 6i, 8c, 8e and 8h demonstrated highly potent dual inhibition of COX-2 (IC50 = 0.037–0.041 μM) and 15-LOX (IC50 = 1.41–1.80 μM). Compounds 6i, 8c and 8h showed 116%, 113% and 109% of the in vivo anti-inflammatory activity of celecoxib. Therefore, compounds 6d, 6f, 6i, 8c, 8e and 8h-j are potent dual inhibitors of COX-2 and 15-LOX. Docking study over COX-2 and 15-LOX active sites ensures the binding affinity and selectivity. These compounds are promising candidates for further development as anti-inflammatory drugs.

AHR INHIBITORS AND USES THEREOF

-

Paragraph 0362; 0363; 0366; 0367, (2019/03/02)

The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.

Total Synthesis of Fontanesine B and Its Isomer: Their Antiproliferative Activity against Human Colorectal Cancer Cells

Abe, Takumi,Itoh, Tomoki,Terasaki, Masaru

, (2019/07/10)

A concise synthesis of pyrano[3,2-e]indole alkaloid fontanesine B by a Fischer indolization is described. This key Fischer indolization starts with the pyran-ring and alkene intact, facilitating potential synthetic applications. Furthermore, fontanesine B and its isomer were evaluated for in vitro antiproliferative activity against human colorectal cancer cells. The isomer of fontanesine B showed higher antiproliferative activity than the natural product, fontanesine B (2).

Process route upstream and downstream products

Process route

4-acetaminophenol
103-90-2,8055-08-1

4-acetaminophenol

acetyl chloride
75-36-5

acetyl chloride

5-acetamido-2-hydroxyacetophenone
7298-67-1

5-acetamido-2-hydroxyacetophenone

Conditions
Conditions Yield
With aluminum (III) chloride; In nitrobenzene; at 130 ℃; for 3.5h;
81.5%
With aluminium trichloride; In nitrobenzene; at 20 - 130 ℃; for 3h;
62%
With aluminium trichloride; Yield given;
With aluminum (III) chloride; In nitrobenzene; Reflux;
With aluminum (III) chloride; In nitrobenzene; at 130 ℃; for 3h;
With aluminum (III) chloride; In nitrobenzene; at 130 ℃; for 3h;
4-acetoxyacetanilide
2623-33-8

4-acetoxyacetanilide

5-acetamido-2-hydroxyacetophenone
7298-67-1

5-acetamido-2-hydroxyacetophenone

Conditions
Conditions Yield
With aluminum (III) chloride; sodium chloride; at 20 - 130 ℃; for 5h;
89%
With zinc(II) chloride; at 180 ℃; for 2h;
75%
In tetrahydrofuran; for 24h; Solvent; Irradiation;
75.1%
With ytterbium trifluoromethanesulfonate; lithium perchlorate; In nitromethane; at 100 ℃; for 8h;
65%
With aluminium trichloride; at 140 ℃; for 2h;
10%
With aluminium trichloride;
With aluminium trichloride; Heating;
1-(2-hydroxy-5-nitrophenyl)ethanone
1450-76-6

1-(2-hydroxy-5-nitrophenyl)ethanone

5-acetamido-2-hydroxyacetophenone
7298-67-1

5-acetamido-2-hydroxyacetophenone

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: hydrogen / 5percent Pd/C / tetrahydrofuran / 2 h / 2068.6 Torr
2: tetrahydrofuran / 0.33 h / 60 °C
With hydrogen; palladium on activated charcoal; In tetrahydrofuran;
o-hydroxyacetophenone
118-93-4,104809-67-8

o-hydroxyacetophenone

5-acetamido-2-hydroxyacetophenone
7298-67-1

5-acetamido-2-hydroxyacetophenone

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 33 percent / nitric acid, glacial acetic acid / 1.) RT, 40 min, 2.) from 45 to 50 deg C, 16 h
2: hydrogen / 5percent Pd/C / tetrahydrofuran / 2 h / 2068.6 Torr
3: tetrahydrofuran / 0.33 h / 60 °C
With hydrogen; nitric acid; acetic acid; palladium on activated charcoal; In tetrahydrofuran;
4-methoxy-aniline
104-94-9

4-methoxy-aniline

5-acetamido-2-hydroxyacetophenone
7298-67-1

5-acetamido-2-hydroxyacetophenone

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sodium acetate; acetic acid
2: aluminum (III) chloride / carbon disulfide / 1.5 h
With aluminum (III) chloride; sodium acetate; acetic acid; In carbon disulfide; 2: Friedel Crafts acylation;
Multi-step reaction with 2 steps
1: dichloromethane / 2 h / 20 °C
2: aluminum (III) chloride / dichloromethane / 4.5 h / Reflux
With aluminum (III) chloride; In dichloromethane; 2: Friedel Crafts acylation;
Multi-step reaction with 3 steps
1: sodium acetate / acetic acid / 0.5 h / 0 °C
2: aluminum (III) chloride / carbon disulfide / 1.5 h / 80 - 90 °C
3: sodium hydroxide; water
With aluminum (III) chloride; water; sodium acetate; sodium hydroxide; In carbon disulfide; acetic acid;
Multi-step reaction with 2 steps
1: sodium acetate; acetic acid / 0.5 h / 0 °C
2: aluminum (III) chloride / carbon disulfide / 1.5 h / 80 - 90 °C
With aluminum (III) chloride; sodium acetate; acetic acid; In carbon disulfide;
Multi-step reaction with 2 steps
1: acetic acid
2: aluminum (III) chloride
With aluminum (III) chloride; acetic acid; 2: |Friedel-Crafts Acylation;
Multi-step reaction with 2 steps
1: dichloromethane / 2 h
2: aluminum (III) chloride / dichloromethane / 6 h / Reflux
With aluminum (III) chloride; In dichloromethane;
Multi-step reaction with 2 steps
1: dichloromethane / 2 h / 30 °C / Inert atmosphere
2: aluminum (III) chloride / dichloromethane / 12 h / Reflux
With aluminum (III) chloride; In dichloromethane; 2: |Friedel-Crafts Acylation;
Multi-step reaction with 2 steps
1: dichloromethane / 6 h / 20 °C
2: aluminum (III) chloride / dichloromethane / 12 h / Reflux
With aluminum (III) chloride; In dichloromethane; 2: |Friedel-Crafts Acylation;
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 2 h / 0 - 15 °C
2: aluminum (III) chloride / carbon disulfide / 2 h / 90 °C
With aluminum (III) chloride; triethylamine; In carbon disulfide; dichloromethane;
Multi-step reaction with 2 steps
1: dichloromethane / 2 h
2: aluminum (III) chloride / dichloromethane / 6 h / Reflux
With aluminum (III) chloride; In dichloromethane;
N-(3-acetylphenyl)-N-hydroxyacetamide

N-(3-acetylphenyl)-N-hydroxyacetamide

5-acetamido-2-hydroxyacetophenone
7298-67-1

5-acetamido-2-hydroxyacetophenone

Conditions
Conditions Yield
With Phenylselenyl bromide; In 1,4-dioxane; at 100 ℃; for 10h;
45%
acetic acid-(3-acetyl-4-methoxy-anilide)
51410-09-4

acetic acid-(3-acetyl-4-methoxy-anilide)

5-acetamido-2-hydroxyacetophenone
7298-67-1

5-acetamido-2-hydroxyacetophenone

Conditions
Conditions Yield
With water; sodium hydroxide;
4-amino-phenol
123-30-8

4-amino-phenol

5-acetamido-2-hydroxyacetophenone
7298-67-1

5-acetamido-2-hydroxyacetophenone

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 52 percent / pyridine / CH2Cl2 / 5 °C
2: 10 percent / aluminium chloride / 2 h / 140 °C
With pyridine; aluminium trichloride; In dichloromethane; 2: Fries rearrangement;
Multi-step reaction with 2 steps
1: pyridine / 100 °C
2: zinc(II) chloride / 2 h / 180 °C
With pyridine; zinc(II) chloride;
Multi-step reaction with 2 steps
1: triethylamine / ethyl acetate / 16 h / 0 - 20 °C
2: aluminum (III) chloride; sodium chloride / 5 h / 20 - 130 °C
With aluminum (III) chloride; triethylamine; sodium chloride; In ethyl acetate; 2: |Fries Phenol Ester Rearrangement;
Multi-step reaction with 2 steps
1: toluene / 9 h / Reflux
2: tetrahydrofuran / 24 h / Irradiation
In tetrahydrofuran; toluene;
4-methoxy-aniline
104-94-9

4-methoxy-aniline

5-acetamido-2-hydroxyacetophenone
7298-67-1

5-acetamido-2-hydroxyacetophenone

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 90 percent / CH2Cl2
2: 87 percent / AlCl3 / CH2Cl2
With aluminium trichloride; In dichloromethane;
5-amino-2-hydroxyacetophenone
50-80-6

5-amino-2-hydroxyacetophenone

acetic anhydride
108-24-7

acetic anhydride

5-acetamido-2-hydroxyacetophenone
7298-67-1

5-acetamido-2-hydroxyacetophenone

Conditions
Conditions Yield
In tetrahydrofuran; at 60 ℃; for 0.333333h; Yield given;

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