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Cas Database

7304-32-7

7304-32-7

Identification

  • Product Name:Benzoicacid, 2-fluoro-5-nitro-

  • CAS Number: 7304-32-7

  • EINECS:-0

  • Molecular Weight:185.111

  • Molecular Formula: C7H4FNO4

  • HS Code:29163990

  • Mol File:7304-32-7.mol

Synonyms:NSC 133450;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:2-Fluoro-5-nitrobenzoic Acid
  • Packaging:50g
  • Price:$ 135
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:2-Fluoro-5-nitrobenzoic Acid
  • Packaging:25g
  • Price:$ 95
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Fluoro-5-nitrobenzoic Acid >98.0%(GC)(T)
  • Packaging:5g
  • Price:$ 63
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Fluoro-5-nitrobenzoic Acid >98.0%(GC)(T)
  • Packaging:25g
  • Price:$ 212
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Fluoro-5-nitrobenzoic acid 98%
  • Packaging:100 g
  • Price:$ 185
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Fluoro-5-nitrobenzoic acid 98%
  • Packaging:25 g
  • Price:$ 65
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-Fluoro-5-nitrobenzoic acid 98%
  • Packaging:5g
  • Price:$ 30
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Fluoro-5-nitrobenzoic acid 97%
  • Packaging:25g
  • Price:$ 28
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Fluoro-5-nitrobenzoic acid 97%
  • Packaging:5g
  • Price:$ 10
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Fluoro-5-nitrobenzoic acid 97%
  • Packaging:100g
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Relevant articles and documentsAll total 12 Articles be found

Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities

Zhu, Huajian,Li, Wenlong,Shuai, Wen,Liu, Yang,Yang, Limei,Tan, Yuchen,Zheng, Tiandong,Yao, Hong,Xu, Jinyi,Zhu, Zheying,Yang, Dong-Hua,Chen, Zhe-Sheng,Xu, Shengtao

, (2021/03/08)

A series of novel N-benzylbenzamide derivatives were designed and synthesized as tubulin polymerization inhibitors. Among fifty-one target compounds, compound 20b exhibited significant antiproliferative activities with IC50 values ranging from 12 to 27 nM against several cancer cell lines, and possessed good plasma stability and satisfactory physicochemical properties. Mechanism studies demonstrated that 20b bound to the colchicine binding site and displayed potent anti-vascular activity. Notably, the corresponding disodium phosphate 20b-P exhibited an excellent safety profile with the LD50 value of 599.7 mg/kg (i.v. injection), meanwhile, it significantly inhibited tumor growth and decreased microvessel density in liver cancer cell H22 allograft mouse model without obvious toxicity. Collectively, 20b and 20b-P are novel promising anti-tubulin agents with more druggable properties and deserve to be further investigated for cancer therapy.

New strategy for detection of hydrogen peroxide based on bi-nucleophilic reaction

Liu, Xiang,Mao, Chenxin,Tian, Yafei,Wang, Bei,Wang, Shuoshuo

supporting information, (2021/07/14)

Two novel fluorescent probes based on 7-hydroxy-4-methyl-coumarin, FAA-MC-OH (2-fluoro-4-nitro-phenylacetyl hydroxyl coumarin) and FBA-MC-OH (2-fluoro-4-nitro-benzoyl hydroxyl coumarin) are first synthesized, and spectral studies confirm that both the pro

Discovery of novel 2-phenylamino-4-prolylpyrimidine derivatives as TRK/ALK dual inhibitors with promising antitumor effects

Cao, Zhi,Guo, Ming,Jiang, Nan,Li, Changtao,Li, Tong,Wang, Xinyu,Yang, Jing,Zhai, Xin

, (2021/10/06)

In order to explore novel TRK and ALK dual inhibitors, a series of 2-phenylamino-4-prolylpyrimidine derivatives were designed, synthesized and evaluated for their in vitro cytotoxicity and enzymatic activities. Delightfully, most compounds were detected m

N-benzylbenzamide derivatives and preparation method and pharmaceutical application thereof

-

Paragraph 0042-0045, (2019/05/08)

The invention relates to the field of pharmaceutical chemistry, discloses N-benzylbenzamide derivatives with antitumor activity and a preparation method thereof, and further discloses pharmaceutical compositions containing the compounds and application of the compounds or pharmaceutical salts thereof or the compositions containing the compounds to preparation of medicines for treating tumors and inhibiting diseases or symptoms related to tubulin activity.

2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS

-

Page/Page column 83, (2012/07/13)

The present invention relates to compounds and compositions acting as inhibitors of HIV integrase. The compound of the invention is of Formula (I), or a tautomer (I') thereof, or a pharmaceutically acceptable salt, or solvate of said compound or tautomer

Process route upstream and downstream products

Process route

o-fluoro-benzoic acid
445-29-4

o-fluoro-benzoic acid

2-fluoro-5-nitrobenzoic acid
7304-32-7

2-fluoro-5-nitrobenzoic acid

2-fluoro-3-nitro-benzoic acid
317-46-4

2-fluoro-3-nitro-benzoic acid

Conditions
Conditions Yield
With nitric acid;
With nitric acid; at 0 ℃;
o-fluoro-benzoic acid
445-29-4

o-fluoro-benzoic acid

2-fluoro-5-nitrobenzoic acid
7304-32-7

2-fluoro-5-nitrobenzoic acid

Conditions
Conditions Yield
With sulfuric acid; nitric acid; at 10 - 25 ℃; for 2h;
93%
With sulfuric acid; nitric acid; at 10 - 30 ℃;
89%
With sulfuric acid; nitric acid; at 80 - 90 ℃; for 0.75h;
88%
With sulfuric acid; potassium nitrate; at 20 ℃;
85%
With sulfuric acid; nitric acid; at 20 ℃; for 2h;
71.2%
With sulfuric acid; nitric acid; at 0 - 20 ℃; for 2h;
71.2%
With sulfuric acid; nitric acid; at 15 - 25 ℃; for 1h;
54%
With sulfuric acid; nitric acid; at 20 ℃;
With sulfuric acid; nitric acid; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;
With sulfuric acid; nitric acid; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;
With sulfuric acid; nitric acid; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;
2-fluoro-5-nitrobenzonitrile
17417-09-3

2-fluoro-5-nitrobenzonitrile

2-fluoro-5-nitrobenzoic acid
7304-32-7

2-fluoro-5-nitrobenzoic acid

Conditions
Conditions Yield
With sulfuric acid; In water; at 100 ℃; for 2h;
76.3%
o-fluoro-benzoic acid
445-29-4

o-fluoro-benzoic acid

2-fluoro-5-nitrobenzoic acid
7304-32-7

2-fluoro-5-nitrobenzoic acid

Conditions
Conditions Yield
With nitric acid; at 0 ℃;
2-Fluorotoluene
95-52-3

2-Fluorotoluene

2-fluoro-5-nitrobenzoic acid
7304-32-7

2-fluoro-5-nitrobenzoic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: KMnO4
2: nitric acid / 0 °C
With potassium permanganate; nitric acid;
Multi-step reaction with 2 steps
1: KMnO4
2: nitric acid / 0 °C
With potassium permanganate; nitric acid;
Multi-step reaction with 2 steps
1: water / Eintragen von Kaliumpermanganat
2: nitric acid
With water; nitric acid;
o-fluoro-benzoic acid
445-29-4

o-fluoro-benzoic acid

2-fluoro-5-nitrobenzoic acid
7304-32-7

2-fluoro-5-nitrobenzoic acid

Conditions
Conditions Yield
at 25 - 30 ℃; Eintragen in Salpetersaeure;
o-fluoro-benzoic acid
445-29-4

o-fluoro-benzoic acid

2-fluoro-5-nitrobenzoic acid
7304-32-7

2-fluoro-5-nitrobenzoic acid

Conditions
Conditions Yield
at 0 ℃;
2-fluoro-5-nitrobenzoic acid
7304-32-7

2-fluoro-5-nitrobenzoic acid

Conditions
Conditions Yield
o-fluoro-benzoic acid
445-29-4

o-fluoro-benzoic acid

2-fluoro-5-nitrobenzoic acid
7304-32-7

2-fluoro-5-nitrobenzoic acid

2-fluoro-3-nitro-benzoic acid
317-46-4

2-fluoro-3-nitro-benzoic acid

Conditions
Conditions Yield
With nitric acid;
With nitric acid; at 0 ℃;
o-fluoro-benzoic acid
445-29-4

o-fluoro-benzoic acid

2-fluoro-5-nitrobenzoic acid
7304-32-7

2-fluoro-5-nitrobenzoic acid

Conditions
Conditions Yield
With sulfuric acid; nitric acid; at 10 - 25 ℃; for 2h;
93%
With sulfuric acid; nitric acid; at 10 - 30 ℃;
89%
With sulfuric acid; nitric acid; at 80 - 90 ℃; for 0.75h;
88%
With sulfuric acid; potassium nitrate; at 20 ℃;
85%
With sulfuric acid; nitric acid; at 20 ℃; for 2h;
71.2%
With sulfuric acid; nitric acid; at 0 - 20 ℃; for 2h;
71.2%
With sulfuric acid; nitric acid; at 15 - 25 ℃; for 1h;
54%
With sulfuric acid; nitric acid; at 20 ℃;
With sulfuric acid; nitric acid; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;
With sulfuric acid; nitric acid; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;
With sulfuric acid; nitric acid; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

Global suppliers and manufacturers

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  • Simagchem Corporation
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  • Amadis Chemical Co., Ltd.
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  • Emails:sales@amadischem.com
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  • Chemwill Asia Co., Ltd.
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  • Emails:chemwill_asia@126.com
  • Main Products:130
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  • Shaanxi BLOOM TECH Co.,Ltd
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  • LIDE PHARMACEUTICALS LIMITED
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  • Shanghai Upbio Tech Co.,Ltd
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  • Career Henan Chemical Co
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  • Chemlyte Solutions
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  • Country:China (Mainland)
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