7344-02-7 Usage
Description
Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway. Certain forms of ceramide have been shown to mediate cellular responses such as apoptosis, growth arrest, and differentiation in certain cell types. C20 Ceramide is a natural 20:0 ceramide that is abundant in the brain. It is synthesized de novo by ceramide synthases 1 and 2.
Chemical Properties
white powder
Uses
C20 Ceramide (cas# 7344-02-7) is a compound useful in organic synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 7344-02-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,3,4 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 7344-02:
(6*7)+(5*3)+(4*4)+(3*4)+(2*0)+(1*2)=87
87 % 10 = 7
So 7344-02-7 is a valid CAS Registry Number.
7344-02-7Relevant articles and documents
Structure-activity relationship of α-galactosylceramides against b16- bearing mice
Morita,Motoki,Akimoto,Natori,Sakai,Sawa,Yamaji,Koezuka,Kobayashi,Fukushima
, p. 2176 - 2187 (2007/10/02)
Agelasphin-9b, (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-16-methyl-2-[N- ((R)-2-hydroxytetracosanoyl)-amino]-1,3,4-heptadecanetriol, is a potent antitumor agent isolated from the marine sponge Agelas mauritianus. Various analogues of agelasphin-9b (a lead compound) were synthesized, and the relationship between their structures and biological activities was examined using several assay systems. From the results, KRN7000, (2S,3S,4R)-1-O-(α- D-galactopyranosyl)-2-(N-hexacosanoylamino)-1,3,4-octadecanetriol, was selected as a candidate for clinical application.
