73502-03-1

Basic information

• Product Name: 5-METHOXY-2-METHYL-BENZOIC ACID METHYL ESTER
• Synonyms: 5-METHOXY-2-METHYL-BENZOIC ACID METHYL ESTER;Methyl 3-methoxy-6-methylbenzoate
• CAS NO: 73502-03-1
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.21
• Mol File: 73502-03-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 254.318°C at 760 mmHg
• Flash Point: 100.309°C
• Appearance: /
• Density: 1.075g/cm³
• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.503
• CAS DataBase Reference: 5-METHOXY-2-METHYL-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-2-METHYL-BENZOIC ACID METHYL ESTER(73502-03-1)
• EPA Substance Registry System: 5-METHOXY-2-METHYL-BENZOIC ACID METHYL ESTER(73502-03-1)

Safety Data

• Hazardous Substances Data: 73502-03-1(Hazardous Substances Data)

Usage

General Description

5-Methoxy-2-methyl-benzoic acid methyl ester is a chemical compound with the molecular formula C10H12O3. It is a methyl ester derivative of 5-methoxy-2-methylbenzoic acid, a compound commonly found in various natural and synthetic products. This chemical is often used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also known for its potential applications in research and analytical chemistry. 5-Methoxy-2-methyl-benzoic acid methyl ester may also have some biological activities and can serve as a starting material for the preparation of other important chemical intermediates.

InChI:InChI=1/C10H12O3/c1-7-4-5-8(12-2)6-9(7)10(11)13-3/h4-6H,1-3H3

Upstream product

• 74-88-4 methyl iodide 
• 823-96-1 Trimethylboroxine 
• 35450-36-3 methyl 2-bromo-5-methoxybenzoate 
• 3168-59-0 5-methoxy-o-toluic acid 
• 118-90-1 ortho-methylbenzoic acid 
• 67-56-1 methanol 
• 77-78-1 dimethyl sulfate 
• 857599-37-2 methyl 2-iodo-5-methoxybenzoate 
• 57772-57-3 5-hydroxy-2-iodo-benzoic acid 
• 394-31-0 2-amino-5-hydroxybenzoic acid 
• 2840-04-2 5-amino-2-methylbenzoic acid 
• 1975-52-6 5-nitro-o-toluic acid 
• 578-22-3 2-methyl-5-hydroxybenzoic acid 
• 544-97-8 dimethyl zinc(II) 

Downstream Products

• 3168-59-0 5-methoxy-o-toluic acid 
• 788081-99-2 methyl 2-(bromomethyl)-5-methoxy-benzoate 
• 1265287-00-0 methyl 5-methoxy-2-(dibromomethyl)-benzoate 
• 73502-04-2 (5-methoxy-2-methylphenyl)methanol 
• 56724-09-5 5-methoxy-2-methylbenzaldehyde 
• 944718-10-9 2-Bromomethyl-6-methoxy-2,3-dihydro-isoindol-1-one 
• 944718-09-6 2,2-Dimethyl-propionic acid 6-methoxy-1-oxo-1,3-dihydro-isoindol-2-ylmethyl ester 
• 22246-66-8 6-methoxy-2,3-dihydro-isoindol-1-one 
• 659737-57-2 6-hydroxy-2,3-dihydro-1H-isoindol-1-one 
• 1885-13-8 4-methoxyphthalic acid 

Relevant articles and documents

Palladium-Catalyzed Tandem Carbonylative Diels-Alder Reaction for Construction of Bridged Polycyclic Skeletons

A palladium-catalyzed tandem carbonylative lactonization and Diels-Alder cycloaddition reaction between aldehyde-tethered benzylhalides and alkenes has been developed. A range of alkenes and aldehyde-tethered benzylhalides bearing different substituents can be successfully transformed into the corresponding bridged polycyclic compounds in good yields. This strategy provides a unique approach to complex lactone-containing bridged polycyclic compounds.

Copper-promoted direct amidation of isoindolinone scaffolds by sodium persulfate

Isoindolinones are ubiquitous structural motifs in natural products and pharmaceuticals. Establishing an efficient method for structural modification of isoindolinones could significantly facilitate new drug development. Herein, we describe copper-promoted direct amidation of isoindolinone scaffolds mediated by sodium persulfate. The method exhibits mild reaction conditions and high site-selectivity, and enables the structural modification of the drug indobufen ester with various amides with yields of 49 to 98%. It is also gram-scalable. Additionally, the reaction mechanism appears to involve a radical and a carbocationic pathway.

Assessment of the regioselectivity in the condensation reaction of unsymmetrical o-phthaldialdehydes with alanine

One approach for the synthesis of isoindolinones, a privileged bioactive heterocyclic core structure, involves a condensation reaction of o-phthaldialdehydes with a suitable nitrogen-containing nucleophile. This fascinating reaction is revisited here in the context of the use of o-phthaldialdehydes that contain additional substituents in the aromatic ring leading to a detailed analysis of the regioselectivity of the reaction. Eleven monosubstituted o-phthaldialdehydes were synthesised and reacted with alanine. The regioselectivity observed across the eleven substrates led to the design of a disubstituted substrate that reacted with very high control. A gram-scale reaction followed by esterification gave one major regioisomer in high yield. In addition, the regioselectivity observed on reaction of two novel monodeuterated substrates led to an increased mechanistic understanding.