7381-30-8

Basic information

• Product Name: 1,2-Bis(trimethylsilyloxy)ethane
• Synonyms: 1,2-bis(trimethylsllyloxy)ethane;2,2,7,7-Tetramethyl-3,6-dioxa-2,7-disilaoctane;3,6-Dioxa-2,7-disilaoctane, 2,2,7,7-tetramethyl-;1,2-BIS(TRIMETHYLSILYLOXY)ETHANE;1,2-BIS(TRIMETHYLSILOXY)ETHANE;1,3-BIS(TRIMETHYLSILOXY)ETHANE;ETHYLENEDIOXYBIS(TRIMETHYLSILANE);ETHYLENE GLYCOL BIS(TRIMETHYLSILYL ETHER)
• CAS NO: 7381-30-8
• Molecular Formula: C₈H₂₂O₂Si₂
• Molecular Weight: 206.43
• EINECS: 230-950-3
• Product Categories: Industrial/Fine Chemicals;Monoalkoxysilanes;Protection & Derivatization Reagents (for Synthesis);Si (Classes of Silicon Compounds);Si-O Compounds;Synthetic Organic Chemistry
• Mol File: 7381-30-8.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 165-166 °C(lit.)
• Flash Point: 115 °F
• Appearance: Clear colorless to faint yellow/Liquid
• Density: 0.842 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.46mmHg at 25°C
• Refractive Index: n20/D 1.403(lit.)
• Storage Temp.: Flammables area
• Sensitive: Moisture Sensitive
• BRN: 1744217
• CAS DataBase Reference: 1,2-Bis(trimethylsilyloxy)ethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Bis(trimethylsilyloxy)ethane(7381-30-8)
• EPA Substance Registry System: 1,2-Bis(trimethylsilyloxy)ethane(7381-30-8)

Safety Data

• Statements: 10
• Safety Statements: 23-24/25-16
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• F: 10-21
• TSCA: No
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 7381-30-8(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS TO FAINT YELLOW LIQUID

Uses

1,2-Bis(trimethylsiloxy)ethane may be used in chemical synthesis studies.

InChI:InChI=1/C8H22O2Si2/c1-11(2,3)9-7-8-10-12(4,5)6/h7-8H2,1-6H3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 107-21-1 ethylene glycol 
• 110-71-4 1,2-dimethoxyethane 
• 16029-98-4 trimethylsilyl iodide 
• 4544-20-1 2-ethoxy-1,3-dioxolane 
• 107-46-0 Hexamethyldisiloxane 
• 936-51-6 2-phenyl-1,3-dioxolane 
• 996-50-9 N,N-diethyl-1,1,1-trimethylsilanamine 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 62185-58-4 triethylene glycol bis(trimethylsilyl) ether 
• 3674-77-9 2-methyl-2-phenyl-1,3-dioxolane 
• 176-32-9 1,4-dioxaspiro[4.4]nonane 
• 2035-08-7 4-methyl-2-pentanone ethylene acetal 
• 4362-57-6 2,2-diethyl-1,3-dioxolane 

Downstream Products

• 1004-58-6 1,4-dioxa-spiro[4.5]dec-6-ene 
• 7092-24-2 1,4-dioxaspiro<4.5>dec-7-ene 
• 105539-21-7 trans-retinal 1,3-dioxolane 
• 979-65-7 3-Ethylendioxy-pregnen-⁽⁴⁾-on-⁽²⁰⁾ 
• 978-98-3 20-ethylenedioxy-4-pregnen-3-one 
• 38223-75-5 4-(2-Methyl-[1,3]dioxolan-2-yl)-cyclohex-1-enecarbaldehyde 
• 105539-25-1 1-(4-[1,3]Dioxolan-2-yl-cyclohex-3-enyl)-ethanone 
• 94113-44-7 6-pentyl-1,4-dioxaspiro[4.4]nonane 
• 98540-65-9 3-(6-Methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-1-phenyl-propan-1-one 
• 98540-66-0 6-Methyl-6-[2-(2-phenyl-[1,3]dioxolan-2-yl)-ethyl]-1,4-dioxa-spiro[4.5]decane 
• 128242-44-4 3-(1-methylethoxy)-4-phenyl-3-cyclobutene-1,2-dione 2-ethylene acetal 
• 26607-23-8 (S)-2-(4-(prop-1-en-2-yl)cyclohex-1-enyl)-1,3-dioxolane 
• 133295-87-1 cis-8a-<<(benzyloxy)methoxy>methyl>-3-(phenylthio)-4a,5,6,8a-tetrahydronaphthalene-1,8(4H,7H)-dione ethyleneketal 
• 127213-09-6 2-acetoxy-4-methylphenyl 2',3'-di-O-acetyl-6'-deoxy-β-D-arabino-5'-hexulofuranoside ethylene acetal 

Relevant articles and documents

Synthesis method of 1, 2-bis (alkyl-siloxy) ethane

The invention provides a synthesis method of 1, 2-bis (alkyl-siloxy) ethane, and belongs to the technical field of battery electrolytic solution additives. The method comprises the following steps: adding dichloromethane and ethylene glycol into a reaction kettle, cooling to 15 DEG C or below, adding imidazole, continuously cooling to -15 DEG C or below, starting to dropwise add vinyl dimethyl chlorosilane or tert-butyl dimethyl chlorosilane or trimethylchlorosilane, controlling the temperature in the dropwise adding process to range from -15 DEG C to -25 DEG C, after dropwise adding is completed for 1.8-2.2 h, washing the system with water, carrying out liquid separation, drying, carrying out suction filtration, collecting dichloromethane under reduced pressure, and rectifying to obtain 1, 2-bis (dimethyl vinyl siloxy) ethane or 1, 2-bis (tert-butyl dimethyl siloxy) ethane or 1, 2-bis (trimethyl siloxy) ethane. The synthesis method is simple, and the yield of the synthesized product is high.

Total synthesis of (-)-hippodamine by stereocontrolled construction of azaphenalene skeleton based on extended one-pot asymmetric azaelectrocyclization

The first asymmetric total synthesis of (-)-hippodamine has been accomplished via the concise construction of its azaphenalene core, which is featured by the 2,4,6-chiral piperidine synthesis based on one-pot asymmetric azaelectrocyclization in the partially activated substituent system and the subsequent intramolecular Mannich reaction.

METHOD OF MANUFACTURING (3R, 4S) -1- (4-FLUOROPHENYL) -3- [ (3S) -3- (4 -FLUOROPHENYL) -3-HYDROXYPROPYL) ] -4- (4-HYD ROXYPHENYL) -2-AZETIDINONE

A method of manufacturing (3R,4S)-l-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3- hydroxypropyl)]-4-(4-hydroxyphenyl)-2-azetidinone (Ezetimibe) of formula I, starting from the optically active (S)-N-acyl-oxazolidide of formula II, which is reacted with an alkyleneglycol of general formula III, (stage 1), and the obtained acetal-oxazolidide of general formula IV, is subjected to reaction with a silyl-imine of general formula V the produced amino-oxazolidide of general formula VI, (stage 3), and the obtained silylated azetidinone of general formula VII, is desilylated (stage 4), and the ketal of general formula VIII produced this way, is deketalized formula IX is finally reduced.