74058-77-8

Basic information

• Product Name: HexadecanaMide, N-(4-hydroxyphenyl)-
• Synonyms: HexadecanaMide, N-(4-hydroxyphenyl)-
• CAS NO: 74058-77-8
• Molecular Formula: C₂₂H₃₇NO₂
• Molecular Weight: 347.53468
• Mol File: 74058-77-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 520.2°C at 760 mmHg
• Flash Point: 268.4°C
• Appearance: /
• Density: 0.987g/cm³
• Vapor Pressure: 1.92E-11mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: HexadecanaMide, N-(4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: HexadecanaMide, N-(4-hydroxyphenyl)-(74058-77-8)
• EPA Substance Registry System: HexadecanaMide, N-(4-hydroxyphenyl)-(74058-77-8)

Safety Data

• Hazardous Substances Data: 74058-77-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-22(25)23-20-16-18-21(24)19-17-20/h16-19,24H,2-15H2,1H3,(H,23,25)

Upstream product

• 123-30-8 4-amino-phenol 
• 120246-99-3 palmitoyl ethyl carbonate 
• 57-10-3 1-hexadecylcarboxylic acid 
• 112-67-4 n-hexadecanoyl chloride 
• 74058-64-3 1-(2-Thioxo-thiazolidin-3-yl)-hexadecan-1-one 

Downstream Products

• 224455-28-1 dibenzyl (4-(palmitoylamino)phenyl) phosphate 

Relevant articles and documents

Synthesis of Acetaminophen Analogues Containing α-Amino Acids and Fatty Acids for Inhibiting Hepatotoxicity

Acetaminophen is a popular antipyretic analgesic medicine that has weaker anti-inflammatory properties and lower incidence of side effects than nonsteroidal anti-inflammatory drugs (NSAIDs). However, acetaminophen causes hepatotoxicity due to the reactive metabolite N -acetyl- p -benzoquinone imine (NAPQI). We have obtained acetaminophen analogues in 57-99percent yields by using aniline derivatives with protected α-amino acids and fatty acids via the corresponding mixed carbonic carboxylic anhydrides in aqueous MeCN. We have also succeeded in synthesizing AM404 analogues in 76-97percent yields, which are expected to be promising candidates for reducing hepatotoxicity.

Structure activity relationships of lysophosphatidic acid: Conformationally restricted backbone mimetics

Lysophosphatidic acid (LPA) has associated with it an intriguing cell biology that is thought to be mediated through its interaction with G- protein coupled receptor(s). In an effort to extend the structure-activity relationships of LPA, we have produced

MONITORED AMINOLYSIS OF 3-ACYLTHIAZOLIDINE-2-THIONE : A NEW CONVENIENT SYNTHESIS OF AMIDE

3-Acylthiazolidine-2-thiones (1) were easily prepared and they were treated with several amines in dichloromethane to give amides 4 in very high yields within a short time.Aminoalcohols and aminophenols were selectively converted into acylaminoalcohols and acylaminophenols, respectively, by this reaction.One can monitor the reaction by disappearance of the yellow color of the starting material 1.Some amide alkaloids (15-18) have effectively been synthesized.