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74115-13-2

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74115-13-2 Usage

Chemical Properties

Light yellow needles

Check Digit Verification of cas no

The CAS Registry Mumber 74115-13-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,1,1 and 5 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 74115-13:
(7*7)+(6*4)+(5*1)+(4*1)+(3*5)+(2*1)+(1*3)=102
102 % 10 = 2
So 74115-13-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H4BrNO/c6-4-1-5(8)3-7-2-4/h1-3,8H

74115-13-2 Well-known Company Product Price

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  • Alfa Aesar

  • (H27256)  3-Bromo-5-hydroxypyridine, 95%   

  • 74115-13-2

  • 1g

  • 283.0CNY

  • Detail
  • Alfa Aesar

  • (H27256)  3-Bromo-5-hydroxypyridine, 95%   

  • 74115-13-2

  • 250mg

  • 948.0CNY

  • Detail
  • Aldrich

  • (691836)  3-Bromo-5-hydroxypyridine  97%

  • 74115-13-2

  • 691836-1G

  • 587.34CNY

  • Detail

74115-13-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Bromo-5-hydroxypyridine

1.2 Other means of identification

Product number -
Other names 5-bromopyridin-3-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:74115-13-2 SDS

74115-13-2Downstream Products

74115-13-2Relevant articles and documents

Synthesis of novel 7-substituted pyrido[2′,3′:4,5]furo[3,2-d] pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases

Deau, Emmanuel,Loidreau, Yvonnick,Marchand, Pascal,Nourrisson, Marie-Renee,Loaec, Nadege,Meijer, Laurent,Levacher, Vincent,Besson, Thierry

, p. 6784 - 6788 (2014/01/06)

The efficient synthesis of 7-substituted pyrido[2′,3′:4,5] furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues is described. 3,5-Dibromopyridine was converted into 3-amino-6-bromofuro[3,2-b]pyridine-2- carbonitrile intermediate which was formylated with DMFDMA. Functionalization at position 7 of the tricyclic scaffold was accomplished, before or after cyclisation step, by palladium-catalyzed Suzuki-Miyaura cross-coupling while the pyrimidin-4-amines and N-aryl counterparts were synthesized by microwave-assisted formamide degradation and Dimroth rearrangement, respectively. The final products were evaluated for their potent inhibition of a series of five Ser/Thr kinases (CDK5/p25, CK1δ/ε, CLK1, DYRK1A, GSK3α/β). Compound 35 showed the best inhibitory activity with an IC50 value of 49 nM and proved to be specific to CLK1 among the panel of tested kinases.

A convenient route to functionalized 3-amino-6-bromofuro[3,2-b]pyridine-2-carboxamides

Bretéché, Anne,Marchand, Pascal,Nourrisson, Marie-Renée,De Nanteuil, Guillaume,Duflos, Muriel

experimental part, p. 4490 - 4494 (2010/07/06)

An efficient synthesis of 3-amino-6-bromofuro[3,2-b]pyridine-2-carboxamides is described via the formation of 3-amino-6-bromofuro[3,2-b]pyridine-2-carbonitrile. Functionalization of the amino group at position 3 of the heterocycle will be discussed.

FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF

-

, (2009/06/27)

The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the specification, except a particular compound, or a salt thereof, and a pharmaceutical agent containing the compound or a prodrug thereof, which is a kinase (VEGFR, VEGFR2, PDGFR, Raf) inhibitor, an angiogenesis inhibitor, an agent for the prophylaxis or treatment of cancer, a cancer growth inhibitor or a cancer metastasis suppressor.

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