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Cas Database

741286-41-9

741286-41-9

Identification

  • Product Name:Ethyl 3-Methyl-a,g-dioxo-benzenebutanoate

  • CAS Number: 741286-41-9

  • EINECS:

  • Molecular Weight:234.252

  • Molecular Formula: C13H14O4

  • HS Code:

  • Mol File:741286-41-9.mol

Synonyms:Ethyl 3-Methyl-a,g-dioxo-benzenebutanoate

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 13 Articles be found

PIKFYVE KINASE INHIBITORS

-

Page/Page column 201, (2021/08/20)

The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.

Design and synthesis of novel 5-arylisoxazole-1,3,4-thiadiazole hybrids as α-glucosidase inhibitors

Akbarzadeh, Tahmineh,Eslami, Azadeh,Faramarzi, Mohammad Ali,Mahdavi, Mohammad,Mirfazli, Seyedeh Sara,Saeedi, Mina,Zardkanlou, Mahsa

, p. 436 - 444 (2021/10/04)

Background: α-Glucosidase inhibitors have occupied a significant position in the treatment of type 2 diabetes. In this respect, the development of novel and efficient non-sugar-based inhibitors is in high demand. Objective: Design and synthesis of new 5-arylisoxazole-1,3,4-thiadiazole hybrids possessing α-glucosidase inhibitory activity were developed. Methods: Different derivatives were synthesized by the reaction of various 5-arylisoxazole-3-carboxylic acids and ethyl 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)acetate. Finally, they were evalu-ated for their α-glucosidase inhibitory activity. Results: It was found that ethyl 2-((5-(5-(2-chlorophenyl)isoxazole-3-carboxamido)-1,3,4-thiadiazol-2-yl)thio)acetate (5j) was the most potent compound (IC50 = 180.1 μM) compared with acarbose as the reference drug (IC50 = 750.0 μM). Also, the kinetic study of 5j revealed a competitive inhibition and docking study results indicated desired interactions of that compound with amino acid residues located close to the active site of α-glucosidase. Conclusion: Good α-glucosidase inhibitory activity obtained by the title compounds introduced them as an efficient scaffold, which merits to be considered in anti-diabetic drug discovery developments.

Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of β-Substituted α-Oxobutyrolactones

Hu, Zi-Qi,Li, Xiang,Liu, Li-Xia,Yu, Chang-Bin,Zhou, Yong-Gui

supporting information, p. 17453 - 17461 (2021/11/18)

A concise and effective ruthenium-catalyzed asymmetric transfer hydrogenation of β-substituted α-oxobutyrolactones has been developed, delivering a series of cis-β-substituted α-hydroxybutyrolactone derivatives with excellent yields, enantioselectivities,

Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors

Dou, Xiaodong,Huang, Huixia,Jiang, Lan,Jiao, Ning,Jin, Hongwei,Liu, Zhenming,Zhang, Liangren,Zhang, Lihe,Zhu, Guiwang

, (2020/07/03)

The c-Jun N-terminal kinase 3 (JNK3) plays key roles in a wide range of diseases, including neurodegeneration diseases, inflammation diseases, cancers, cardiovascular diseases, and metabolic disorders. Previously, we have identified a lead compound, (Z)-3

Green and efficient synthesis of new pyrido[2,3-d]pyrimidine derivatives using Pd/SBA-15 as a nanocatalyst

Bardajee, Ghasem Rezanejade,Delbari, Akram Sadat,Ghaedi, Aseyeh,Hekmat, Shohreh

, (2020/09/07)

N-Fused heterocycles have received significant attention over the years as valuable compounds due to their biological and pharmaceutical activities. Heterogeneous catalysts such as periodic mesoporous materials have played an important role in the synthes

Process route upstream and downstream products

Process route

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

3-Methylacetophenone
585-74-0

3-Methylacetophenone

ethyl 2,4-dioxo-4-m-tolylbutanoate
741286-41-9

ethyl 2,4-dioxo-4-m-tolylbutanoate

Conditions
Conditions Yield
oxalic acid diethyl ester; With sodium methylate; In diethyl ether; at 20 ℃; Inert atmosphere;
3-Methylacetophenone; In diethyl ether; at 20 ℃; for 12h;
82%
3-Methylacetophenone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -20 - 0 ℃; for 1h; Inert atmosphere;
oxalic acid diethyl ester; In tetrahydrofuran; at -20 - 20 ℃; for 2h;
70%
With sodium methylate; In diethyl ether; at 20 ℃; for 15h;
With sodium ethanolate; In ethanol; at 0 - 20 ℃;
With sodium ethanolate; In ethanol; at 120 ℃; for 0.333333h; Sealed tube; Microwave irradiation;
With sodium ethanolate; In ethanol; at 0 - 20 ℃;
With sodium hydride; In toluene; at 90 ℃; for 2h;
With ethanol; sodium; at 0 - 20 ℃; for 4h;
With sodium ethanolate; In ethanol; at 0 - 20 ℃;
With sodium ethanolate; In ethanol; at 0 - 20 ℃; for 15h;
With sodium ethanolate; In ethanol; at 0 - 20 ℃; Inert atmosphere; Schlenk technique;
m-tolyl aldehyde
620-23-5

m-tolyl aldehyde

ethyl 2,4-dioxo-4-m-tolylbutanoate
741286-41-9

ethyl 2,4-dioxo-4-m-tolylbutanoate

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 3.17 h / 0 - 20 °C / Inert atmosphere
2: silica gel; manganese(IV) oxide / acetonitrile / 8 h / 70 °C / Molecular sieve
3: sodium hydride / toluene / 2 h / 90 °C
With manganese(IV) oxide; silica gel; sodium hydride; In tetrahydrofuran; toluene; acetonitrile;
ethyl 2,4-dioxo-4-m-tolylbutanoate
741286-41-9

ethyl 2,4-dioxo-4-m-tolylbutanoate

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: silica gel; manganese(IV) oxide / acetonitrile / 8 h / 70 °C / Molecular sieve
2: sodium hydride / toluene / 2 h / 90 °C
With manganese(IV) oxide; silica gel; sodium hydride; In toluene; acetonitrile;
ethyl 2,4-dioxo-4-m-tolylbutanoate
741286-41-9

ethyl 2,4-dioxo-4-m-tolylbutanoate

Conditions
Conditions Yield
81%
ethyl 2,4-dioxo-4-m-tolylbutanoate
741286-41-9

ethyl 2,4-dioxo-4-m-tolylbutanoate

ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate
1316754-28-5,942040-14-4

ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate

Conditions
Conditions Yield
With hydrazine hydrate; acetic acid; In ethanol; at 20 ℃; for 16h;
95.1%
With hydrazine; In acetic acid; at 20 ℃;
78%
With acetic acid; hydrazine; at 20 ℃; for 12h;
2,6-diamino-3H-pyrimidin-4-one
100643-27-4,143504-99-8

2,6-diamino-3H-pyrimidin-4-one

ethyl 2,4-dioxo-4-m-tolylbutanoate
741286-41-9

ethyl 2,4-dioxo-4-m-tolylbutanoate

ethyl 2-amino-3,4-dihydro-4-oxo-5-(m-tolyl)pyrido[2,3-d]pyrimidine-7-carboxylate

ethyl 2-amino-3,4-dihydro-4-oxo-5-(m-tolyl)pyrido[2,3-d]pyrimidine-7-carboxylate

Conditions
Conditions Yield
With Pd(II) complex supported on SBA-15 nanocatalyst; In water; at 100 ℃; for 3h; Green chemistry;
75%
5-hydrazinyl-2-methoxypyridine hydrochloride
179543-88-5,524699-82-9

5-hydrazinyl-2-methoxypyridine hydrochloride

ethyl 2,4-dioxo-4-m-tolylbutanoate
741286-41-9

ethyl 2,4-dioxo-4-m-tolylbutanoate

1-(6-methoxy-3-pyridyl)-5-(3-methylphenyl)pyrazole-3-carboxylic acid ethyl ester
741291-47-4

1-(6-methoxy-3-pyridyl)-5-(3-methylphenyl)pyrazole-3-carboxylic acid ethyl ester

Conditions
Conditions Yield
With triethylamine; In ethanol; at 20 ℃; for 14h; Heating / reflux;
62%
1H-benzimidazol-2-acetonitrile
4414-88-4

1H-benzimidazol-2-acetonitrile

ethyl 2,4-dioxo-4-m-tolylbutanoate
741286-41-9

ethyl 2,4-dioxo-4-m-tolylbutanoate

ethyl 4-cyano-1-(m-tolyl)benzo[4,5]imidazo[1,2-a]pyridine-3-carboxylate

ethyl 4-cyano-1-(m-tolyl)benzo[4,5]imidazo[1,2-a]pyridine-3-carboxylate

Conditions
Conditions Yield
With piperidine; In ethanol; Reflux;
65%
ethyl 2,4-dioxo-4-m-tolylbutanoate
741286-41-9

ethyl 2,4-dioxo-4-m-tolylbutanoate

ethyl 5-(3-methylphenyl)isoxazole-3-carboxylate
893638-47-6

ethyl 5-(3-methylphenyl)isoxazole-3-carboxylate

Conditions
Conditions Yield
With hydroxylamine hydrochloride; In ethanol; for 3h; Reflux;
With hydroxylamine hydrochloride; sodium methylate; In ethanol; Reflux;
With hydroxylamine hydrochloride; In ethanol; for 2h; Reflux;
With hydroxylamine hydrochloride; In ethanol; for 3h; Reflux;
ethyl 2,4-dioxo-4-m-tolylbutanoate
741286-41-9

ethyl 2,4-dioxo-4-m-tolylbutanoate

4-cyano-1,2-phenylenediamine
17626-40-3

4-cyano-1,2-phenylenediamine

(Z)-2-oxo-3-(2-oxo-2-(m-tolyl)ethylidene)-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile

(Z)-2-oxo-3-(2-oxo-2-(m-tolyl)ethylidene)-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile

Conditions
Conditions Yield
In ethanol; at 20 ℃; for 4h;

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  • NovaChemistry
  • Business Type:Trading Company
  • Contact Tel:+44 (0)208 191 7890
  • Emails:info@novachemistry.com
  • Main Products:1
  • Country:United Kingdom
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