744-25-2

Basic information

• Product Name: 2-Phenylhydrazono-3-piperidinopropiophenon
• Synonyms: 2-Phenylhydrazono-3-piperidinopropiophenon
• CAS NO: 744-25-2
• Molecular Weight: 321.422
• Mol File: 744-25-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Phenylhydrazono-3-piperidinopropiophenon(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenylhydrazono-3-piperidinopropiophenon(744-25-2)
• EPA Substance Registry System: 2-Phenylhydrazono-3-piperidinopropiophenon(744-25-2)

Safety Data

• Hazardous Substances Data: 744-25-2(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 50-00-0 formaldehyd 
• 5335-28-4 phenyl-glyoxal-2-phenylhydrazone 
• 880-09-1 di(N-piperidinyl)methane 
• 94860-72-7 3-hydroxy-1-phenyl-2-(2-phenylhydrazono)propan-1-one 

Relevant articles and documents

α-dicarbonylmonophenylhydrazones as nucleophiles and neighbouring groups

The α-dicarbonylmonophenylhydrazones 1 and 8 do not react as simple "CH-acidic compounds" in the Mannich condensation reaction. In a concerted reaction with aminals in absolute dioxane they give rise to the products 5a-e and 10a-e with better practicability and much higher yields compared with the conventional method. The formal Mannich bases 5a/ 5b/5d and 10a/10b/10d with a cyclic amine part show in the dehydrogenation, using mercury-EDTA, a neighbouring group participation of the phenylhydrazono moiety yielding the corresponding lactams. With 5c only cyclization occurs leading to 1,2,4-triazine 19 in low yield, while 10c shows no dehydrogenation but an amine elimination to the vinyl-azo compound 21 with consecutive cycloaddition leading to the 1,2-diazine 23.