7459-33-8

Basic information

• Product Name: LINOLEOYL CHLORIDE
• Synonyms: (9Z,12Z)-9,12-Octadecadienoic acid chloride;[(9Z,12Z)-1-Oxo-9,12-octadecadienyl] chloride;Linoleic acid chloride;Linoleoyl Choride;(z,z)-12-octadecadienoylchloride;LINOLEOYL CHLORIDE;DELTA 9-12 CIS OCTADECADIENOYL CHLORIDE;(9Z,12Z)-octadeca-9,12-dienoyl chloride
• CAS NO: 7459-33-8
• Molecular Formula: C₁₈H₃₁ClO
• Molecular Weight: 298.89
• EINECS: 231-233-8
• Product Categories: Acid ChloridesUnsaturated fatty acids and derivatives;Omega 6 fatty acids and derivatives;Polyunsaturated;Unsaturated fatty acids and derivatives
• Mol File: 7459-33-8.mol
• Article Data: 56

Chemical Properties

• Boiling Point: 150-152 °C (0.5 mmHg)
• Flash Point: 183.658 °C
• Appearance: dark brown liquid or oil
• Density: 0.93
• Vapor Pressure: 5.31E-06mmHg at 25°C
• Refractive Index: 1.47-1.49
• Storage Temp.: Refrigerator
• CAS DataBase Reference: LINOLEOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: LINOLEOYL CHLORIDE(7459-33-8)
• EPA Substance Registry System: LINOLEOYL CHLORIDE(7459-33-8)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 28A-26-45-36/37/39-27
• RIDADR: UN 3265 8/PG 2
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 7459-33-8(Hazardous Substances Data)

Usage

Chemical Properties

dark brown liquid or oil

InChI:InChI=1/C18H31ClO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3/b7-6+,10-9+

Upstream product

• 60-33-3 linoleic acid 
• 119520-47-7 (9Z,12Z)-N-Pyridin-3-yl-octadeca-9,12-dienimidothioic acid pyridin-2-yl ester 
• 119520-51-3 (9Z,12Z)-N-(pyridin-3-yl)octadeca-9,12-dienamide 
• 822-17-3 sodium linoleate 
• 79-37-8 oxalyl dichloride 
• 75-44-5 phosgene 

Downstream Products

• 604-33-1 cholesterol linoleate 
• 3999-01-7 linoleamide 
• 27097-98-9 (9Z,12Z)-Octadeca-9,12-dienoic acid 3-[(2-chloro-ethoxy)-(4-nitro-benzyloxy)-phosphoryloxy]-propyl ester 
• 2190-12-7 α-Stearoyl-β-linoleoyl-α'-palmitoin 
• 2258-95-9 L-(-)-α-Stearoyl-β-linoloyl-α'-trityl-glycerin 
• 6542-05-8 1,2-Dilinoleoyl-sn-glycerol-3-phosphorylcholine 
• 998-06-1 (R)-2,3-bis(((9Z,12Z)-octadeca-9,12-dienoyl)oxy)propyl (2-(trimethylammonio)ethyl) phosphate 
• 122941-14-4 (9Z,12Z)-Octadeca-9,12-dienoic acid 3-((9Z,12Z)-octadeca-9,12-dienoyl)-2,4-dioxo-cyclohexyl ester 
• 132910-96-4 p-Nitrophenyl 30-(linoleoyloxy)triacontanoate 
• 365425-51-0 dimethyl 3-[4-[(9Z,12Z)-9,12-octadecadienoylamino]benzoylamino]-3',4-oxydibenzoate 
• 5299-71-8 (9Z,12Z)-1-(morpholin-4-yl)octadeca-9,12-dien-1-one 
• 498548-58-6 (9Z,12Z)-Octadeca-9,12-dienoic acid (E)-2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinyl ester 
• 135391-16-1 m-Linoleoylaminoaniline 
• 1373719-21-1 1-O-linoleoyl-5-O-trityl-D-arabinitol 

Relevant articles and documents

Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals

Fatty acid esters of hydroxy fatty acids (FAHFAs) are a recently discovered class of biologically active lipids. Here we identify the linoleic acid ester of 13-hydroxy linoleic acid (13-LAHLA) as an anti-inflammatory lipid. An oat oil fraction and FAHFA-enriched extract from this fraction showed anti-inflammatory activity in a lipopolysaccharide-induced cytokine secretion assay. Structural studies identified three LAHLA isomers (15-, 13-, and 9-LAHLA) as being the most abundant FAHFAs in the oat oil fraction. Of these LAHLAs, 13-LAHLA is the most abundant LAHLA isomer in human serum after ingestion of liposomes made of fractionated oat oil, and it is also the most abundant endogenous LAHLA in mouse and human adipose tissue. As a result, we chemically synthesized 13-LAHLA for biological assays. 13-LAHLA suppresses lipopolysaccharide-stimulated secretion of cytokines and expression of pro-inflammatory genes. These studies identify LAHLAs as an evolutionarily conserved lipid with anti-inflammatory activity in mammalian cells.

GLYCEROL DERIVATIVE, PREPARATION METHOD THEREFOR, AND IMMUNOMODULATOR COMPRISING SAME AS EFFECTIVE INGREDIENT

Disclosed are a glycerol derivative that is useful for improving, preventing or treating inflammation-related diseases by inhibiting overexpression of various inflammatory cytokines such as IL-4, IL-6 and so on, or chemokine CXCL8 and reducing migration of HL-60 cell lines, preparation method therefor, and an immunomodulator containing the same as active ingredient. It includes a glycerol derivative represented by Chemical formula 2 or 3 in the specification.

3-PYRROLIDINE-INDOLE DERIVATIVES AS SEROTONERGIC PSYCHEDELIC AGENTS FOR THE TREATMENT OF CNS DISORDERS

The present application relates to 3-cyclic amine-indole derivatives of general Formula (I), to processes for their preparation, to compositions comprising them and to their use in activation of a serotonin receptor in a cell, as well as to treating diseases, disorders or conditions by activation of a serotonin receptor in a cell. The diseases, disorders or conditions include, for example, psychosis, mental illnesses, and other neurological diseases, disorders and conditions. Formula (I)