74592-33-9

Basic information

• Product Name: 1-(AMINOMETHYL)-CYCLOPROPANOL
• Synonyms: 1-(AMINOMETHYL)-CYCLOPROPANOL;1-(AMinoMethyl)cyclopropanol HCl;1-(Aminomethyl)-1-cyclopropanol;1-(aMinoMethyl)cyclopropan-1-ol;Cyclopropanol, 1-(aminomethyl)-
• CAS NO: 74592-33-9
• Molecular Formula: C4H9NO
• Molecular Weight: 87.12
• EINECS: 1533716-785-6
• Mol File: 74592-33-9.mol

Chemical Properties

• Boiling Point: 153.7°C at 760 mmHg
• Flash Point: 46.7°C
• Appearance: /
• Density: 1.186g/cm³
• Vapor Pressure: 1.22mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.99±0.20(Predicted)
• CAS DataBase Reference: 1-(AMINOMETHYL)-CYCLOPROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(AMINOMETHYL)-CYCLOPROPANOL(74592-33-9)
• EPA Substance Registry System: 1-(AMINOMETHYL)-CYCLOPROPANOL(74592-33-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 74592-33-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(AMINOMETHYL)-CYCLOPROPANOL is used as a chemical reactant for the preparation of 5-lipoxygenase activating protein (FLAP) inhibitors. These inhibitors are crucial in the treatment of inflammatory diseases, as they help regulate the inflammatory response by targeting specific enzymes involved in the production of inflammatory mediators.

InChI:InChI=1/C4H9NO/c5-3-4(6)1-2-4/h6H,1-3,5H2

Upstream product

• 428855-17-8 1-((diphenylmethylamino)methyl)cyclopropan-1-ol 

Relevant articles and documents

Synthesis method of 1-aminomethyl-1-cyclopropanol

The invention discloses a synthetic method of 1-aminomethyl-1-cyclopropanol. The synthetic method comprises the following steps: adding a compound C00 into an aqueous potassium carbonate solution to form a first solution; adding an aqueous solution of C01 into the first solution for a reaction; combining organic phases, carrying out cleaning with saline water, and performing drying, filtering andconcentrating to obtain a compound C02; dissolving the compound C02 in tetrahydrofuran to form a second solution; adding tetraisopropyl titanate into the second solution to form a third solution; adding an ethyl magnesium bromide solution into the third solution for a reaction; adding an aqueous ammonium chloride solution into the solution for a quenching reaction; combining organic layers to obtain a compound C03; dissolving the compound C03 into an absolute ethyl alcohol solution to form a fourth solution; adding a sodium hydroxide solution into the fourth solution; adding a hydroxylamine hydrochloride solution into the fourth solution to form a fifth solution; and adding a sodium hydroxide solution into the fifth solution until the pH value is 6-7, and carrying out distilling to removea water phase, thereby obtaining the product, i.e., 1-aminomethyl-1-cyclopropanol. In this way, palladium hydroxide is not used as a catalyst, and synthesis cost is reduced.

BENZAMIDES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF

Provided is a novel class of orally and/or topically available, selective and potent JAK inhibitors as safe and effective therapeutics against various diseases and disorders. More particularly, provided are pharmaceutical composition of these compounds and methods of their preparation and use thereof.

A convenient procedure for preparation of 1-(1-aminoalkyl)-1-cyclopropanols from N-benzyl α-amino acid esters

The reaction of N-benzyl α-amino acid ethyl esters with ethylmagnesium bromide in the presence of a catalytic amount of titanium tetraisopropoxide leads to formation of the corresponding 1-aminoalkyl-1-cyclopropanols in high yields. Hydrogenation of the l