7463-30-1

Basic information

• Product Name: 2-ACETAMIDO-3-PICOLINE
• Synonyms: 2-ACETAMIDO-3-PICOLINE;[N-3-METHYL-2-PYRIDYL] ACETAMIDE;2-Acetamido-3-picoline ,97%;2-Acetamido-3-methylpyridine;N-(3-Methylpyridin-2-yl)acetamide;N-(3-Methyl-2-pyridinyl)-AcetaMide;Acetamide,N-(3-methyl-2-pyridinyl)-;N-(3-Methylpyridine-2-yl)acetamide
• CAS NO: 7463-30-1
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Product Categories: Heterocyclic Compounds
• Mol File: 7463-30-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 92 °C
• Boiling Point: 325.5 °C at 760 mmHg
• Flash Point: 150.7 °C
• Appearance: /
• Density: 1.137 g/cm³
• Vapor Pressure: 0.000229mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: Room temperature.
• Solubility: soluble in Methanol
• CAS DataBase Reference: 2-ACETAMIDO-3-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETAMIDO-3-PICOLINE(7463-30-1)
• EPA Substance Registry System: 2-ACETAMIDO-3-PICOLINE(7463-30-1)

Safety Data

• Hazardous Substances Data: 7463-30-1(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C8H10N2O/c1-6-4-3-5-9-8(6)10-7(2)11/h3-5H,1-2H3,(H,9,10,11)

Upstream product

• 108-99-6 3-Methylpyridine 
• 75-05-8 acetonitrile 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 108-24-7 acetic anhydride 

Downstream Products

• 23612-48-8 2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 91668-83-6 2-Chloro-3-methylpyridine N-oxide 
• 37538-65-1 4-aminopyrido[2,3-d]pyrimidine 
• 28732-79-8 4-chloro-pyrido[2,3-d]pyrimidine 
• 7255-87-0 2-amino-3H-pyrido[2,3-d]pyrimidin-4-one 
• 91996-76-8 2-chloro-3H-pyrido[2,3-d]pyrimidine-4-thione 
• 126728-20-9 2,4-dichloropyrido[2,3-d]pyrimidine 
• 91996-78-0 4-thioxo-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one 
• 37891-04-6 2-thioxo-2,3-dihydropyrido/2,3-d/pyrimidin-4(1H)-one 
• 108902-48-3 phenyl-pyrido[2,3-d]pyrimidin-4-yl-amine 
• 95769-04-3 2-anilino-3H-pyrido[2,3-d]pyrimidin-4-one 
• 21038-66-4 1H-Pyrido[2,3-d]pyrimidine-2,4-dione 
• 3430-21-5 5-bromo-3-methyl-pyridin-2-ylamine 

Relevant articles and documents

Preparation method of 2, 5-dibromo-3-methylpyridine

The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of 2, 5-dibromo-3-methylpyridine. The preparation method comprises the following steps: (1) adding 2-amino-3-methylpyridine and acetic anhydride into a four-neck flask, heating to reflux, and carrying out thin-layer chromatography tracking reaction; (2) when the temperature of a reaction liquid obtained in the step (1) is reduced to 20-25 DEG C, dropwise adding liquid bromine, reacting for 2-3 hours at 50-60 DEG C after dropwise adding of liquid bromine, adding water until all solids are dissolved, dropwise adding a sodium hydroxide solution, continuously reacting for 30 minutes after dropwise adding, and carrying out suction filtration, drying and recrystallization to obtain 2-amino-3-methyl-5-bromopyridine; and (3) adding the obtained 2-amino-3-methyl-5-bromopyridine into a hydrogen bromide solution, dropwise adding a saturated sodium nitrite solution under the catalysis of cuprous bromide, controlling the temperature to be -5 to 10 DEG C, and reacting for 2 to 4 hours to obtain 2, 5-dibromo-3-methylpyridine. The method provided by the invention has the beneficial effects ofmild reaction conditions, high yield, low cost and short process route, and is suitable for industrial production.

Efficient synthesis of 2-substituted 7-azaindole derivatives via palladium-catalyzed coupling and C-N cyclization using 18-crown-6

A practical and straightforward preparation of various novel 2-substituted 7-azaindole derivatives from 2-amino-3-iodopyridine by a two-step procedure is described that gives the desired compounds in good overall yields. Georg Thieme Verlag Stuttgart.