7464-17-7

Basic information

• Product Name: 1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea
• CAS NO: 7464-17-7
• Molecular Formula: C₈H₉ClN₄S
• Molecular Weight: 228.7019
• Mol File: 7464-17-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 391.6°C at 760 mmHg
• Flash Point: 190.6°C
• Density: 1.48g/cm³
• Vapor Pressure: 2.43E-06mmHg at 25°C
• Refractive Index: 1.688
• CAS DataBase Reference: 1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea(7464-17-7)
• EPA Substance Registry System: 1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea(7464-17-7)

Safety Data

• Hazardous Substances Data: 7464-17-7(Hazardous Substances Data)

Usage

General Description

1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea, also known as chlormidazole, is a chemical compound with potential antimicrobial and antifungal properties. It is a thiourea derivative that contains a chlorophenyl group and a diaminoalkylidene group. Chlormidazole has been studied for its potential use in the treatment of various fungal and bacterial infections, as well as for its antifungal activity against dermatophytes, which are fungi that cause skin infections. Additionally, it has also been investigated for its potential use in the treatment of acne due to its antimicrobial properties. However, further research is needed to fully understand the potential therapeutic uses and safety profile of 1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea.

Upstream product

• 50-01-1 guanidine hydrochloride 
• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 196877-91-5 1-(4-Chloro-phenyl)-3-[(3,5-dimethyl-pyrazol-1-yl)-imino-methyl]-thiourea 
• 113-00-8 guanidine nitrate 
• 124-46-9 guanidine hydrogen carbonate 
• 593-84-0 guanidinium thiocyanate 

Downstream Products

• 1154520-35-0 3-(4-acetyl-phenyl)-2-[4-amino-2-(4-chlorophenylamino)-thiazol-5-yl]-3H-quinazolin-4-one 
• 1154520-34-9 2-[4-amino-2-(4-chloro-phenylamino)-thiazol-5-yl]-3-(4-chloro-phenyl)-3H-quinazolin-4-one 
• 857010-29-8 1-(4-chloro-phenyl)-6,6,N²-trimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine 
• 107401-72-9 [4-amino-2-(4-chlorophenylamino)thiazol-5-yl](4-chlorophenyl)methanone 
• 132533-34-7 N⁵-(4-Chloro-phenyl)-[1,2,4]thiadiazole-3,5-diamine 
• 857396-97-5 N-carbamimidoyl-N'-(4-chloro-phenyl)-S-methyl-isothiourea 
• 46440-97-5 1-(4-chloro-phenyl)-2-methyl-biguanide 

Relevant articles and documents

NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS

The present invention disclosed a novel EGFR inhibitor compound of formula (I), process for preparation thereof and methods of treating abnormal cell growth in mammals by administering the compounds of formula (I). Wherein, R= -H, 3-CH3, 4-NO2, 4-Cl, 2-CH3, 4-CH3, 4-Br, 4-F R1= -H, -4-OCH3, -4-NO2,-2-NO2, -4-Cl, -2,4,6-CH3, -4-CH3, -2-F,4-Br, -4-CF3, -4-S-CH3, -4-Cl,-3-CF3, -3-S-CH3, -3,5-CF3, -2-S-CH3, -3-CF3,-4-OCF3, -Si-(CH3)3, -Si-(C2H5)3, (CH3)2-Si- C2H5.

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