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Cas Database

7470-38-4

7470-38-4

Identification

  • Product Name:Benzoic acid,4-(4-morpholinyl)-

  • CAS Number: 7470-38-4

  • EINECS:

  • Molecular Weight:207.229

  • Molecular Formula: C11H13 N O3

  • HS Code:2934999090

  • Mol File:7470-38-4.mol

Synonyms:4-(4-Morpholinyl)benzoicacid; 4-Morpholinobenzoic acid; NSC 402784

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Safety information and MSDS view more

  • Pictogram(s):

  • Hazard Codes:Xi,Xn

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowed

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
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  • Price
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  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:4-MorpholinobenzoicAcid
  • Packaging:500mg
  • Price:$ 75
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-(4-Morpholinyl)benzoic Acid
  • Packaging:5G
  • Price:$ 108
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-(4-Morpholinyl)benzoic Acid
  • Packaging:1G
  • Price:$ 36
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Morpholin-4-ylbenzoic acid
  • Packaging:250 mg
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Morpholin-4-ylbenzoic acid
  • Packaging:25 g
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Morpholin-4-ylbenzoic acid
  • Packaging:5 g
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  • Manufacture/Brand:SynChem
  • Product Description:4-Morpholin-4-yl-benzoic acid 95+%
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  • Manufacture/Brand:SynChem
  • Product Description:4-Morpholin-4-yl-benzoic acid 95+%
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  • Manufacture/Brand:SynChem
  • Product Description:4-Morpholin-4-yl-benzoic acid 95+%
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  • Manufacture/Brand:Sigma-Aldrich
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Relevant articles and documentsAll total 9 Articles be found

Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors

Wei, Manman,Peng, Xia,Xing, Li,Dai, Yang,Huang, Ruimin,Geng, Meiyu,Zhang, Ao,Ai, Jing,Song, Zilan

, p. 9 - 28 (2018/05/28)

Starting from the phase II clinical FGFR inhibitor lucitanib (2), we conducted a medicinal chemistry approach by opening the central quinoline skeleton coupled with a scaffold hopping process thus leading to a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives. Compound 25a was identified to show selective and equally high potency against FGFR1/2 and VEGFR2 with IC50 values less than 5.0 nM. Significant antiproliferative effects on both FGFR1/2 and VEGFR2 aberrant cancer cells were observed. In the SNU-16 xenograft model, compound 25a showed tumor growth inhibition rates of 25.0% and 81.0% at doses of 10 mg/kg and 50 mg/kg, respectively, with 5% and 10%body weight loss. In view of the synergistic potential of FGFs and VEGFs in tumor angiogenesis observed in preclinical studies, the FGFR/VEGFR2 dual inhibitor 25a may achieve better clinical benefits.

Buchwald-Hartwig amination reaction of aryl halides using heterogeneous catalyst based on Pd nanoparticles decorated on chitosan functionalized graphene oxide

Sarvestani, Mosayeb,Azadi, Roya

, (2017/10/05)

In this work, graphene oxide was functionalized with chitosan (GO-Chit) followed by a simple approach for immobilization of palladium nanoparticles onto a chitosan grafted graphene oxide surface. The Pd-nanocomposite (GO-Chit-Pd) was characterized using Transmission Electron Microscopy (TEM), Fourier transforms infrared spectroscopy (FT-IR), and X-ray diffraction (XRD) measurements. The catalytic activity of the prepared heterogeneous graphene oxide functionalized chitosan-palladium (GO-Chit-Pd) was investigated in term of C-N coupling reaction (Buchwald-Hartwig amination reaction of aryl halides) yielding products of N-arylamines. The easy purification, convenient operation, and environmental friendliness, combined with a high yield, render this method viable for use in both laboratory research and larger industrial scales. Studying the reusability of the catalyst in this work showed that it could be reused for five times without obvious loss in catalytic activity.

Convenient Synthesis of p-Aminobenzoic Acids and their Methyl Esters

Pietrzak, Marek,J?drzejewska, Beata,M?drzejewska, Dorota,Bajorek, Agnieszka

, p. 45 - 52 (2017/01/22)

-

Novel 4-(morpholin-4-yl)-N′-(arylidene)benzohydrazides: Synthesis, antimycobacterial activity and QSAR investigations

Raparti, Vyankatesh,Chitre, Trupti,Bothara, Kailas,Kumar, Vanaja,Dangre, Sudarshan,Khachane, Chetan,Gore, Suraj,Deshmane, Bhavana

experimental part, p. 3954 - 3960 (2009/12/04)

A series of 4-(morpholin-4-yl)-N′-(arylidene)benzohydrazides were synthesized using appropriate synthetic route. Antimycobacterial activity of the synthesized compounds (5a-5j) was carried out and percentage reduction in relative light units (RLU) was calculated using luciferase reporter phages (LRP) assay. Percentage reduction in relative light units (RLU) for isoniazid was also calculated. The test compounds showed significant antitubercular activity against Mycobacterium tuberculosis H37Rv and clinical isolates: S, H, R, and E resistant M. tuberculosis, when tested in vitro. Quantitative structure-activity relationship (QSAR) investigation with 2D-QSAR analysis was applied to find a correlation between different experimental or calculated physicochemical parameters of the compounds studied and 3D-QSAR analysis and to indicate the exact steric and electronic requirements in the ranges at various positions around pharmacophore. In general Schiff bases exhibit antimycobacterial activity and morpholine ring is important for antimicrobial activity. So we have synthesized 10 different 4-(morpholin-4-yl)-N′-(arylidene)benzohydrazides. The structures of new compounds were characterized by TLC, FTIR, 1H NMR, mass spectral data and elemental analysis. Amongst the compounds tested 5d and 5c were found to be the most potent, while 5i, 5e, and 5j were found to have an average activity against M. tuberculosis H37Rv and 5a, 5f, 5h, 5g, and 5b were found to have a greater activity against clinical isolates: S, H, R, and E resistant M. tuberculosis as compared to M. tuberculosis H37Rv.

Study of the microwave-assisted hydrolysis of nitriles and esters and the implementation of this system in rapid microwave-assisted Pd-catalyzed amination

Van Baelen, Gitte,Maes, Bert U.W.

, p. 5604 - 5619 (2008/09/21)

Microwave-assisted hydrolysis of benzonitriles and methyl benzoates has been studied using a toluene/concd aq KOH two phase system in the presence and absence of phase transfer catalyst. Conditions to allow and avoid smooth hydrolysis could be identified. Based on the latter, the first microwave protocol which allows the rapid Pd-catalyzed amination of aliphatic amines with chlorobenzenes containing sensitive functional groups has been developed.

Process route upstream and downstream products

Process route

4-fluorobenzoic acid ethyl ester
451-46-7

4-fluorobenzoic acid ethyl ester

4-morpholin-4-yl-benzoic acid
7470-38-4

4-morpholin-4-yl-benzoic acid

Conditions
Conditions Yield
With hydrogenchloride; sodium hydroxide; In water;
90%
4-(4-morpholinyl)benzaldehyde
1204-86-0

4-(4-morpholinyl)benzaldehyde

4-morpholin-4-yl-benzoic acid
7470-38-4

4-morpholin-4-yl-benzoic acid

Conditions
Conditions Yield
With potassium hydroxide; sodium hydroxide; In neat (no solvent); Heating;
69%
4-(morpholin-4-yl)benzoic acid ethyl ester
19614-15-4

4-(morpholin-4-yl)benzoic acid ethyl ester

4-morpholin-4-yl-benzoic acid
7470-38-4

4-morpholin-4-yl-benzoic acid

Conditions
Conditions Yield
With sodium hydroxide; In methanol; water; at 60 ℃; for 4h;
4-morpholinobenzonitrile
10282-31-2

4-morpholinobenzonitrile

4-morpholin-4-yl-benzoic acid
7470-38-4

4-morpholin-4-yl-benzoic acid

Conditions
Conditions Yield
With sodium hydroxide; for 5h; Reflux;
98.34%
With hydrogenchloride; at 100 ℃;
With potassium hydroxide; In 1,4-dioxane; water;
1.21 g (99%)
2-ethyl-4-fluorobenzonitrile
934012-95-0

2-ethyl-4-fluorobenzonitrile

4-fluorobenzonitrile
1194-02-1,143234-87-1

4-fluorobenzonitrile

4-morpholin-4-yl-benzoic acid
7470-38-4

4-morpholin-4-yl-benzoic acid

Conditions
Conditions Yield
With hydrogenchloride; sodium hydroxide;
80%
4-Bromobenzoic acid
586-76-5

4-Bromobenzoic acid

4-morpholin-4-yl-benzoic acid
7470-38-4

4-morpholin-4-yl-benzoic acid

Conditions
Conditions Yield
With potassium tert-butylate; In N,N-dimethyl-formamide; at 100 ℃; for 12h;
88%
4-morpholin-4-yl-benzoic acid methyl ester
23676-05-3

4-morpholin-4-yl-benzoic acid methyl ester

4-morpholin-4-yl-benzoic acid
7470-38-4

4-morpholin-4-yl-benzoic acid

Conditions
Conditions Yield
With potassium hydroxide; In toluene; at 150 ℃; for 1h; microwave irradiation;
4-fluorobenzonitrile
1194-02-1,143234-87-1

4-fluorobenzonitrile

4-morpholin-4-yl-benzoic acid
7470-38-4

4-morpholin-4-yl-benzoic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: dimethylformamide / 100 °C
2: aq. HCl / 100 °C
With hydrogenchloride; In N,N-dimethyl-formamide;
2,2,2-trifluoro-1-(4-morpholin-4-yl-phenyl)-ethanone
70783-44-7

2,2,2-trifluoro-1-(4-morpholin-4-yl-phenyl)-ethanone

4-morpholin-4-yl-benzoic acid
7470-38-4

4-morpholin-4-yl-benzoic acid

Conditions
Conditions Yield
With sodium hydroxide; In N,N-dimethyl-formamide; for 2h;
2,2,2-trifluoro-1-(4-fluorophenyl)ethanone
655-32-3

2,2,2-trifluoro-1-(4-fluorophenyl)ethanone

4-morpholin-4-yl-benzoic acid
7470-38-4

4-morpholin-4-yl-benzoic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: Et3N / dimethylsulfoxide / 0.5 h
2: aq. NaOH / dimethylformamide / 2 h
With sodium hydroxide; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;

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