7476-41-7

Basic information

• Product Name: 2-methyl-1-oxo-1-phenylpropan-2-yl acetate
• Synonyms: 1-Propanone, 2- (acetyloxy)-2-methyl-1-phenyl-
• CAS NO: 7476-41-7
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.2378
• Mol File: 7476-41-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 290.4°C at 760 mmHg
• Flash Point: 124°C
• Density: 1.082g/cm³
• Vapor Pressure: 0.00207mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: 2-methyl-1-oxo-1-phenylpropan-2-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-1-oxo-1-phenylpropan-2-yl acetate(7476-41-7)
• EPA Substance Registry System: 2-methyl-1-oxo-1-phenylpropan-2-yl acetate(7476-41-7)

Safety Data

• Hazardous Substances Data: 7476-41-7(Hazardous Substances Data)

Upstream product

• 5170-76-3 2-methyl-1-phenyl-1-acetoxy-1-propene 
• 64-19-7 acetic acid 
• 39158-85-5 2-methyl-1-phenyl-1-trimethylsiloxy-1-propene 
• 18649-43-9 4-methoxyphenyllead(IV) triacetate 
• 118284-49-4 N-(2-methyl-1-phenylprop-1-en-1-yl)acetamide 
• 100-42-5 styrene 
• 100-52-7 benzaldehyde 
• 7473-98-5 2-hydroxy-2-methylpropiophenone 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 151452-00-5 (p-methoxyphenyl)-alpha,alpha-dimethylphenacyllead diacetate 
• 15805-98-8 O-acetyl-α-hydroxyisobutyric acid 
• 611-70-1 phenyl isopropyl ketone 
• 40635-66-3 2-acetoxy-2-methylpropanoyl chloride 

Downstream Products

• 611-70-1 phenyl isopropyl ketone 
• 120166-55-4 2-methyl-1-phenyl-1-pivaloyloxy-1-propene 
• 15958-02-8 5,5-dimethyl-4-phenyl-5H-furan-2-one 
• 7473-98-5 2-hydroxy-2-methylpropiophenone 

Relevant articles and documents

Synthesis and evaluation of 1,1,7,7-tetramethyl-9-azajulolidine (TMAJ) as a highly active derivative of N,N-dimethylaminopyridine

1,1,7,7-Tetramethyl-9-azajulolidine (TMAJ), which theoretical studies have suggested as a highly active DMAP analog, was synthesized for the first time. The catalytic activity of TMAJ was confirmed by the acetylation reactions of various tert-alcohols. TMAJ showed much higher catalytic activity than DMAP and one of the highest activity levels among the conventional DMAP analogs. These experimental results were in good agreement with the previous theoretical studies.

N-Heterocyclic Carbene-Catalyzed Decarboxylative Alkylation of Aldehydes

We found that N-heterocyclic carbene catalysis promoted the unprecedented decarboxylative coupling of aryl aldehydes and tertiary or secondary alkyl carboxylic acid-derived redox-active esters to produce aryl alkyl ketones. The mild and transition-metal-free reaction conditions are attractive features of this method. The power of this protocol was demonstrated by the functionalization of pharmaceutical drugs and natural product. A reaction pathway involving single electron transfer from an enolate form of Breslow intermediate to a redox ester followed by recombination of the resultant radical pair to form a carbon-carbon bond is proposed.

Visible Light Mediated Reductive Cleavage of C-O Bonds Accessing α-Substituted Aryl Ketones

C-O σ-bonds in multifaceted benzoin derivatives can be effectively cleaved as acetates using catalytic amounts of [Ru(bpy)3]Cl2 as photoredox catalyst in combination with Hantzsch ester and triethylamine as a sacrificial electron donor. This mild and operationally simple method is applicable to a great variety of substrates. Homo- and cross-benzoins, which are easily accessed by NHC (N-heterocyclic carbene) catalysis, with both electron-withdrawing and electron-donating substituents, including aryl halogenides, can be employed. The deoxygenated counterparts are isolated in good to excellent yields. These broadly accessible, α-substituted (nonsymmetric) aryl ketones are versatilely applicable for further transformations as illustrated by the syntheses of 2-arylbenzofurans.