7479-28-9

Basic information

• Product Name: (4-acetyloxy-2,3,6-trimethyl-phenyl) acetate
• Synonyms: (4-acetyloxy-2,3,6-trimethyl-phenyl) acetate
• CAS NO: 7479-28-9
• Molecular Formula: C₁₃H₁₆O₄
• Molecular Weight: 0
• Mol File: 7479-28-9.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 308.7°C at 760 mmHg
• Flash Point: 146.6°C
• Appearance: /
• Density: 1.106g/cm³
• Vapor Pressure: 0.000671mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: (4-acetyloxy-2,3,6-trimethyl-phenyl) acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (4-acetyloxy-2,3,6-trimethyl-phenyl) acetate(7479-28-9)
• EPA Substance Registry System: (4-acetyloxy-2,3,6-trimethyl-phenyl) acetate(7479-28-9)

Safety Data

• Hazardous Substances Data: 7479-28-9(Hazardous Substances Data)

Usage

General Description

(4-acetyloxy-2,3,6-trimethyl-phenyl) acetate, also known as ethyl 3-hydroxy-2,4,6-trimethylbenzoate, is an organic compound with a chemical formula C13H16O4. It is a white crystalline solid with a sweet and floral odor, and is commonly used as a fragrance and flavoring agent in the production of perfumes, cosmetics and food products. It is also used in the synthesis of various organic compounds and pharmaceuticals. This chemical is isobutyr (methyl-2-methylpropionate) used for synthesis of derivatives and esters of acethylted mixed acid to be used in perfumes and fragrances. The compound is known to have low toxicity and is considered safe for use in consumer products when used in accordance with safety guidelines.

InChI:InChI=1/C13H16O4/c1-7-6-12(16-10(4)14)8(2)9(3)13(7)17-11(5)15/h6H,1-5H3

Upstream product

• 700-13-0 Trimethylhydroquinone 
• 64-19-7 acetic acid 
• 2416-94-6 2,3,6-trimethylphenol 
• 68491-55-4 4-hydroxy-2,3,5-trimethylphenyl acetate 
• 108-24-7 acetic anhydride 
• 1125-21-9 2,6,6-trimethyl-2-cyclohexene-1,4-dione 
• 75-36-5 acetyl chloride 
• 7549-37-3 citral dimethyl acetal 
• 1187761-90-5 (E/Z)-3,7-dimethylocta-2,7-dienal dimethyl acetal 
• 66641-69-8 C₂₂H₄₄O₂ 
• 78-59-1 3,5,5-Trimethylcyclohex-2-en-1-one 
• 20547-99-3 2,6,6-trimethyl-1,4-cyclohexanedione 
• 697-82-5 2,3,5-trimethylphenol 
• 20794-18-7 6-Acetoxy-2,5,6-trimethyl-2,4-cyclohexadien-1-on 

Downstream Products

• 18910-34-4 3-acetoxy-6-hydroxy-2,4,5-trimethylbenzyl chloride 
• 64794-45-2 3,4,6-trimethyl-2,5-dihydroxyacetophenone 
• 66901-79-9 5'-acetoxy-2'-hydroxy-3',4',6'-trimethylacetophenone 
• 59-02-9 vitamin E 
• 58-95-7 RRR-α-tocopheryl acetate 
• 58-95-7 vitamin E acetate 
• 123-86-4 acetic acid butyl ester 
• 36592-62-8 4-acetoxy-2,3,5-trimethylphenol 
• 68491-55-4 4-hydroxy-2,3,5-trimethylphenyl acetate 

Relevant articles and documents

Substrate substitution effects in the Fries rearrangement of aryl esters over zeolite catalysts

The catalytic transformation of aryl esters to hydroxyacetophenones via Fries rearrangement over solid acids is of interest to avoid the use of corrosive and toxic Lewis and Br?nsted acids traditionally applied. Microporous zeolites are known to catalyze the reaction of simple substrates such as phenyl acetate, but their application to substituted derivatives has received limited attention. To refine structure-activity relationships, here we examine the impact of various parameters including the solvent polarity, water content, acidic properties, and framework type on the reaction scheme in the Fries rearrangement of p-tolyl acetate over common solid acids. The results confirm the importance of providing a high concentration of accessible Br?nsted acid sites, with beta zeolites exhibiting the best performance. Extension of the substrate scope by substituting methyl groups in multiple positions identifies a framework-dependent effect on the rearrangement chemistry and highlights the potential for the transformation of dimethylphenyl acetates. Kinetic studies show that the major competitive path of cleavage of the ester C-O bond usually occurs in parallel to the Fries rearrangement. The possibility of sequentially acylating the resulting phenol depends on the substrate and reaction conditions.

A 2, 3, 5-trimethyl hydroquinone b phytanate method for the preparation of

The invention provides a preparation method of 2,3,5-trimethylhydroquinone dialkyl acid ester. The preparation method comprises the following steps: under catalysis of polymer ionic liquid, carrying out rearrangement and acylation reaction on 2,6,6-trimethyl cyclohexyl-2-ene-1, 4-diketone and an acylating agent to prepare the 2,3,5-trimethylhydroquinone dialkyl acid ester. Compared with the traditional acid catalysis, the process has the advantages of easiness in recovering of the catalyst, environmental friendliness, slight corrosion to equipment, high activity, high selectivity and the like.

Spiro derivatives as lipoxygenase inhibitors

The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful