7487-88-9

Basic information

• Product Name: Magnesium sulfate
• Synonyms: Arrosalt2327;Epsom salt;Epsom salts;MG-OK 100;MN 30;Magnesium sulfate (1:1);Mg-OK;OT-S;OT-S (drying agent);Sulfuric acid magnesium salt;Sulfuric acid, magnesium salt (1:1);TomixOT;Magnesium sulfate anhydrous;Magnesium sulfate;Magnesium Sulphate
• CAS NO: 7487-88-9
• Molecular Formula: Mg*O₄S
• Molecular Weight: 120.36
• EINECS: 231-298-2
• Mol File: 7487-88-9.mol
• Article Data: 48

Chemical Properties

• Melting Point: 1124℃
• Boiling Point: 330 °C at 760 mmHg
• Appearance: White crystalline powder
• Density: 2.66 g/cm³
• CAS DataBase Reference: Magnesium sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: Magnesium sulfate(7487-88-9)
• EPA Substance Registry System: Magnesium sulfate(7487-88-9)

Safety Data

• Safety Statements: S24/25:
• Hazardous Substances Data: 7487-88-9(Hazardous Substances Data)

Usage

General Description

Magnesium sulfate, also known as Epsom salt, is a chemical compound made up of magnesium, sulfur, and oxygen. It is commonly used in medicine as a magnesium supplement and as a treatment for magnesium deficiency. It is also used as a laxative and as a remedy for constipation. In addition to its medical uses, magnesium sulfate is used in agriculture as a fertilizer, in food as a flavor enhancer, and in various industrial applications. It is also used in the production of some types of hard cheese and tofu, and as a coagulant in the manufacture of tofu.

InChI:InChI=1/Mg.H2O4S.2H/c;1-5(2,3)4;;/h;(H2,1,2,3,4);;/p-2/rH2Mg.H2O4S/c;1-5(2,3)4/h1H2;(H2,1,2,3,4)/p-2

Synthetic route

sulfuric acid (7664-93-9) + hydrogen iodide (10034-85-2) + magnesium oxide → magnesium sulfate (7487-88-9) + magnesium iodide

Conditions	Yield
70 °C; 1-2. step of Mg-S-I water splitting cycle;	A 100% B 100%

copper(ll) sulfate pentahydrate + magnesium oxide → magnesium sulfate (7487-88-9) + copper(II) oxide

Conditions	Yield
In solid byproducts: H2O; mixt. heating in derivatograph in Pt crucible at 10 K/min in air up to 850°C; TG, DTG, DTA;	A 78.7% B n/a
In solid byproducts: H2O; mixt. heating in derivatograph in Pt crucible at 10 K/min in air up to 1000°C; TG, DTG, DTA;	A 47.2% B n/a

zinc(II) sulfate heptahydrate + magnesium oxide → magnesium sulfate (7487-88-9) + zinc(II) oxide

Conditions	Yield
In solid byproducts: H2O; mixt. heating in derivatograph in Pt crucible at 10 K/min in air up to 1000°C; TG, DTG, DTA;	A 73.8% B n/a

dolomite + sulfur dioxide (7446-09-5) → magnesium sulfate (7487-88-9)

Conditions	Yield
In water byproducts: CaSO4; aq. suspension of dolomite was treated with SO2-containing gas with formation of sol. sulfites, air was passed through the soln. forming the sulfates, Ca was removed as CaSO4;; MgSO4-soln. obtained;;

dolomite + sulfur dioxide (7446-09-5) + oxygen (80937-33-3) → calcium sulfate + magnesium sulfate (7487-88-9)

Conditions	Yield
In solid heating at 600-900 °C; X-ray diffraction;

dolomite + sulfuric acid (7664-93-9) → magnesium sulfate (7487-88-9)

Conditions	Yield
In sulfuric acid dolomite was dissolved in H2SO4;; MgSO4 was not isolated;;
In sulfuric acid dolomite was dissolved in H2SO4;; MgSO4 was not isolated;;

dolomite + sodium hydrogensulfite → magnesium sulfate (7487-88-9)

Conditions	Yield
In water byproducts: CaSO4; aq. suspension of dolomite was treated with NaHSO3-soln. at elevated temp., air was passed through the soln.;; MgSO4-soln. obtained;;

sodium hydrogen sulfate (7681-38-1) + dolomite → magnesium sulfate (7487-88-9)

Conditions	Yield
In water dolomite was dissolved in NaHSO4-soln.;; MgSO4 was not isolated;;

ammonium sulfate + dolomite → magnesium sulfate (7487-88-9)

Conditions	Yield
In water byproducts: CaSO4; calcined dolomite was heated with (NH4)2SO4-soln., Mg was dissolved as MgSO4 while Ca remained as CaSO4 in the residue;; MgSO4 was not isolated;;
In water byproducts: CaSO4; calcined dolomite was heated with (NH4)2SO4-soln., Mg was dissolved as MgSO4 while Ca remained as CaSO4 in the residue;; MgSO4 was not isolated;;

magnesium sulfate heptahydrate → magnesium sulfate (7487-88-9)

Conditions	Yield
byproducts: H2O; thermal dehydration;
With sulfuric acid In neat (no solvent) byproducts: H2O; heating with H2SO4 to avoid decompn., removal of the excess of H2SO4 at 600 to 700°C;;
With sulfuric acid In neat (no solvent) byproducts: H2O; heating with H2SO4 to avoid decompn.;;

magnesium sulfate heptahydrate + sodium (7440-23-5) → magnesium hydroxide + magnesium sulfate (7487-88-9) + sodium sulfate (7757-82-6)

Conditions	Yield
In water byproducts: H2; dissolution of sodium in a concd. aq. soln. of Epsom salt (MgSO4*7H2O) at room temp. under stirring in air; filtration, drying of residue under infra-red lamp, drying of soln. at 100°C;

magnesium hydroxoborate + sulfuric acid (7664-93-9) → boric acid (11113-50-1) + magnesium sulfate (7487-88-9)

Conditions	Yield
In sulfuric acid Kinetics; aq. H2SO4; dissolved with stirring in H2SO4 or H2SO4 saturated with boric acid; XRD;

sulfur dioxide (7446-09-5) + iodine (7553-56-2) + magnesium oxide → magnesium sulfate (7487-88-9) + magnesium iodide

Conditions	Yield
In water iodine and aq. sulfur dioxide agitated until a colorless soln. obtainedthen addn. of MgO at 70°C, stirring for several minutes;	A >99 B n/a

sodium thiosulfate → mercury sulfide + magnesium sulfate (7487-88-9)

Conditions	Yield
With magnesium oxide; mercury dichloride In water byproducts: NaCl; reaction mixt. boiled;
With MgO; HgCl2 In water byproducts: NaCl; reaction mixt. boiled;

ascharite + sulfuric acid (7664-93-9) → boric acid (11113-50-1) + magnesium sulfate (7487-88-9)

Conditions	Yield
In sulfuric acid Kinetics; aq. H2SO4; dissolved with stirring in H2SO4 or H2SO4 saturated with boric acid; XRD;

magnesium oxide → magnesium hyposulfite (857209-61-1) + magnesium sulfide + magnesium sulfate (7487-88-9) + sulfur (7704-34-9)

Conditions	Yield
With sulfur dioxide In neat (no solvent) heating MgO with SO2;; formation of sulfide, sulfate, thiosulfate, and S partly as intermediates ;;
With SO2 In neat (no solvent) heating MgO with SO2;; formation of sulfide, sulfate, thiosulfate, and S partly as intermediates ;;

magnesium oxide → magnesium sulfate (7487-88-9)

Conditions	Yield
With sulfur Irradiation (UV/VIS); influence of UV irradiation faster reaction; in presence of water; other product polythionates probably tetra- or pentathionate;

lead(II) sulfide + magnesium oxide → magnesium sulfate (7487-88-9)

Conditions	Yield
With oxygen In neat (no solvent) byproducts: lead oxide; reaction of MgO with PbS on heating in presence of O2 with intermediate formation of sulfide; heating to 800-900 °C in N2 atm. causes no reaction);;
With O2 In neat (no solvent) byproducts: lead oxide; reaction of MgO with PbS on heating in presence of O2 with intermediate formation of sulfide; heating to 800-900 °C in N2 atm. causes no reaction);;

1-Decene (872-05-9) + magnesium sulfate (7487-88-9) + copper(II) chloride (7447-39-4) + palladium dichloride → 2-methyl decanoic acid (24323-23-7)

Conditions	Yield
With hydrogenchloride; carbon monoxide In tetrahydrofuran; sodium hydroxide; water	100%

1-(2,5-difluoro-4-nitrophenyl)piperidine-4-carbaldehyde + magnesium sulfate (7487-88-9) → (S)-3-(5-(4-((1-(2,5-difluoro-4-nitrophenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Conditions	Yield
With triethylamine	100%

4-chloro-2,6-lutidine (3512-75-2) + ethereal hydrogen chloride + magnesium sulfate (7487-88-9) → 2-(N-(2,6-dimethyl-pyridin-4-yl)-N-methylamino)ethanol (193001-81-9)

Conditions	Yield
In (2-hydroxyethyl)(methyl)amine; ethyl acetate	90%

{(4R,6S)-6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid (894787-93-0) + magnesium sulfate (7487-88-9) → (6-{(E)-2-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-vinyl}-(4R,6S)-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid magnesium salt

Conditions	Yield
Stage #1: {(4R,6S)-6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid With sodium hydroxide In water Stage #2: magnesium sulfate In water at 20℃;	90%

[PdCl2(1-(2-diphenylphosphino-ethyl)-4-methyl-piperazine)] (912803-25-9, 912803-37-3) + water (7732-18-5) + magnesium sulfate (7487-88-9) → [PdCl(1-(2-diphenylphosphino-ethyl)-4-methyl-piperazine)][Mg(SO4)2(H2O)4]0.5*6H2O

Conditions	Yield
In methanol byproducts: MgCl2; Pd complex was treated in air with MgSO4 in MeOH; mixt. was stirred at room temp. for 36 h; filtered; solvent removed (vac.);	89%

magnesium sulfate (7487-88-9) → magnesium oxide + sulfur (7704-34-9)

Conditions	Yield
With acetylene In neat (no solvent) redn. with acetylene in a stream of CO2 at 700°C;; MgO containes coal;;	A n/a B 87.5%
With benzene In neat (no solvent) redn. with benzene in a stream of CO2 at 700°C;; MgO containes coal;;	A n/a B 19.2%

C36H34N2O12(2-)*2K(1+) + magnesium sulfate (7487-88-9) → C36H36Mg2N2O14

Conditions	Yield
In propan-1-ol; ethanol at 30℃; Reflux;	85%

levodopa (59-92-7) + magnesium sulfate (7487-88-9) + glycine (56-40-6) → Mg(L-3,4-dioxyphenylalanine)(glycine)

Conditions	Yield
Stage #1: levodopa; glycine With barium(II) hydroxide In water at 20℃; for 0.25h; Stage #2: magnesium sulfate In water at 20℃; for 2.5h; Reflux;	85%

magnesium hydroxide + 2-thiopheneglyoxylic acid (4075-59-6) + di-isopropyl ether (108-20-3) + magnesium sulfate (7487-88-9) + pyrographite (7440-44-0) → syn-2-Hydroxyimino-2-(thien-2-yl)acetic acid (38157-67-4)

Conditions	Yield
With hydrogenchloride; hydroxylamine hydrochloride In water; 1,2-dichloro-ethane	84.5%

1-(5-nitropyrimidin-2-yl)piperidine-4-carbaldehyde + magnesium sulfate (7487-88-9) → 2-(2,6-dioxopiperidin-3-yl)-5-(4-((1-(5-nitropyrimidin-2-yl)piperidin-4-yl)methyl)piperazin-1-yl)isoindoline-1,3-dione

Conditions	Yield
With triethylamine	84%

magnesium sulfate (7487-88-9) + 7-Aminocephalosporanic acid t-butyl ester (6187-87-7) → (6R)-3-acetoxymethyl-7t-benzylideneamino-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester (36954-82-2)

Conditions	Yield
In benzene	82%

1-phenyl-1-t-butoxycarbonylamino-2-(1-ethoxyethoxy)but-3-ene + magnesium sulfate (7487-88-9) + sodium sulfate (7757-82-6) → threo-2-(1-Ethoxyethoxy)-3-tert-butyloxycarbonylamino-3-phenylpropionic acid

Conditions	Yield
With hydrogenchloride; sodium periodate; sodium chloride; sodium hydrogencarbonate; RuCl3 In tetrachloromethane; dichloromethane; water; acetonitrile	77%

magnesium sulfate (7487-88-9) + 2-(p-chlorophenyl)-3-hydroxy-3-methylbutyric acid (193673-86-8) → 2-(4-chlorophenyl)-3-methylcrotonic acid (33131-40-7)

Conditions	Yield
With conc. sulphuric acid In CH2; hexane; dichloromethane; water	76.6%

magnesium sulfate (7487-88-9) + methyl vinyl ketone (78-94-4) → 3-methyl-1-penten-4-yn-3-ol (3230-69-1)

Conditions	Yield
With sulfuric acid; sodium In diethyl ether; ammonia; water	67%

N-(2-methyl-4-methoxy-5-nitrophenyl)acetamide (196194-97-5) + magnesium sulfate (7487-88-9) → 2-acetamido-5-methoxy-4-nitrobenzoic acid (196194-98-6)

Conditions	Yield
With potassium permanganate In water	54%

(1-cyclopropyl-2-oxo-3-pyrrolidinyl)triphenyl-phosphonium bromide + Diphenylmethyl [6R-(6α,7β)]-7-[[(1,1-dimethylethoxy)carbonyl]amino]-3-formyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (135263-64-8) + sodium hydrogencarbonate (144-55-8) + magnesium sulfate (7487-88-9) → [6R-[3(E),6α,7β]]-3-[(1-Cyclopropyl-2-oxo-3-pyrrolidinylidene)-methyl]-7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester (161675-43-0)

Conditions	Yield
With hydrogenchloride; sodium hydroxide In tetrahydrofuran; water; ethyl acetate; toluene	49%

esomeprazole potassium + magnesium sulfate (7487-88-9) → esomeprazole magnesium salt

Conditions	Yield
In methanol at 0 - 30℃; for 3.5 - 5h; Product distribution / selectivity;	45%

β-aminoenone of 1,3-di-(p-chlorophenyl)-1,3-propanedione + 2,4-bis(p-chlorophenyl)-5-cyanopyrrole (143253-15-0) + magnesium sulfate (7487-88-9) + 2-aminoacetonitrile (540-61-4) → 2,4-Bis(p-chlorophenyl)-3-bromo-5-cyanopyrrole

Conditions	Yield
With bromine In tetrahydrofuran; ethanol; acetic acid; N,N-dimethyl-formamide	44%

ethyl 5-methyl-1-triphenylmethyl-4-1H-imidazolecarboxylate + magnesium sulfate (7487-88-9) → 4-Hydroxymethyl-5-methyl-1-(triphenylmethyl)imidazole (106147-84-6)

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; methanol; dichloromethane; water	36%

2-(pyridin-3-ylmethyl)-1H-imidazole-4,5-dicarboxylic acid + water (7732-18-5) + magnesium sulfate (7487-88-9) → 10Mg(2+)*6C11H6N3O4(3-)*33H2O*O4S(2-)

Conditions	Yield
With triethylamine In ethanol at 170℃; for 72h; Autoclave; High pressure;	35%

magnesium sulfate (7487-88-9) → sulfur trioxide (7446-11-9) + magnesium oxide

Conditions	Yield
995 °C in N2; part of a Mg-S-I water splitting cycle;	A 30% B 30%
In neat (no solvent) heating at 950-1050 K (effusion orifices with A/a ratios of 10-30);
1120-1200°C; 29,1mol% in 15min; 90mol% in 2h;
900°C, in air stream;

C27H30N12O6 + water (7732-18-5) + magnesium sulfate (7487-88-9) → O4S(2-)*2H2O*2C27H30N12O6*H12MgO6(2+)

Conditions	Yield
In methanol for 730.5h; Solvent;	30%

ammonia (7664-41-7) + water (7732-18-5) + Ru2(5+)*4HO4P(2-)*4H2O*3H(1+) + magnesium sulfate (7487-88-9) → Ru2(5+)*2HO4P(2-)*16H2O*H3N*H(1+)*2Mg(2+)*2O4P(3-)

Conditions	Yield
Stage #1: Ru2(5+)*4HO4P(2-)*4H2O*3H(1+); magnesium sulfate at 15℃; for 1h; Stage #2: ammonia; water at 20℃; for 2h; pH=Ca. 3.5;	30%

Upstream product

• 7446-09-5 sulfur dioxide 
• 80937-33-3 oxygen 
• 7664-93-9 sulfuric acid 
• 7681-38-1 sodium hydrogen sulfate 
• 7440-23-5 sodium 
• 7553-56-2 iodine 
• 7439-95-4 magnesium 
• 7789-48-2 magnesium bromide 
• 7786-30-3 magnesium chloride 
• 10544-50-0 sulfur 
• 7664-41-7 ammonia 
• 7704-34-9 sulfur 

Downstream Products

• 861321-52-0 2-(2-oxo-cyclohexyl)-glutaric acid 
• 100-65-2 N-Phenylhydroxylamine 
• 586-96-9 Nitrosobenzene 
• 306-08-1 Homovanillic acid 
• 5447-38-1 2-(4-acetoxy-3-methoxyphenyl)acetic acid 
• 563-80-4 3-methyl-butan-2-one 
• 78-79-5 isoprene 
• 909878-64-4 meso-erythritol 
• 3412-44-0 (1E)-1,3-diphenylpropene 
• 110-15-6 succinic acid 
• 64-19-7 acetic acid 
• 64-18-6 formic acid 
• 617-48-1 malic acid 
• 802294-64-0 propionic acid 

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