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75158-11-1

75158-11-1

Identification

Synonyms:2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 3 Articles be found

Optically active iminocarboxylic acid derivatives

-

, (2008/06/13)

The compounds of the formula STR1 wherein R is OH, NH2, lower-alkyl-NH or phenyl-lower alkyl-NH are presented. These compounds can be catalytically hydrogenated to the corresponding α-aminocarboxylic acid derivatives which are intermediates in the synthesis of therapeutic pseudopeptides.

Synthesis, enzymic degradation, lipophilic properties, and biological activity of [D-alanine2, t-butylglycine 5]enkephalin amide

Fauchere,Petermann

, p. 824 - 831 (2007/10/02)

L-C(a)-t-Butylglycine (Bug), its amide, methyl ester, and N(a)-t-butoxycarbonyl derivative were prepared by an asymmetric synthesis, and the Hansch side-chain hydrophobic (lipophilicity) parameter determined. A new enkephalin analogue, H . Tyr-D-Ala-Gly-Phe-Bug . HN2 was synthesized which is pharmacologically active in two in vitro assays and strongly resistant against a number of enzymes in vitro.

Process route upstream and downstream products

Process route

(S,S)-3,3-dimethyl-2-(1-phenylethylamino)butyronitrile
75158-10-0

(S,S)-3,3-dimethyl-2-(1-phenylethylamino)butyronitrile

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide
75158-11-1

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide

Conditions
Conditions Yield
With sulfuric acid; for 48h; Ambient temperature;
77%
pivalaldehyde
630-19-3

pivalaldehyde

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide
75158-11-1

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: diethyl ether / -10 °C
2: 75 percent / ethanol
3: 81 percent / H2SO4
With sulfuric acid; In diethyl ether; ethanol;
Multi-step reaction with 2 steps
1: 82 percent / methanol / 20 h / Ambient temperature
2: 77 percent / conc. sulfuric acid / 48 h / Ambient temperature
With sulfuric acid; In methanol;
2-<(S)-α-methylbenzylamino>-3,3-dimethylbutyronitrile

2-<(S)-α-methylbenzylamino>-3,3-dimethylbutyronitrile

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide
75158-11-1

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide

Conditions
Conditions Yield
With sulfuric acid;
81%
(S)-(-)-α-methylbenzylamine hydrochloride
17279-30-0

(S)-(-)-α-methylbenzylamine hydrochloride

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide
75158-11-1

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 82 percent / methanol / 20 h / Ambient temperature
2: 77 percent / conc. sulfuric acid / 48 h / Ambient temperature
With sulfuric acid; In methanol;
(<i>S</i>)-1-phenyl-ethylamine
2627-86-3

(S)-1-phenyl-ethylamine

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide
75158-11-1

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: diethyl ether / -10 °C
2: 75 percent / ethanol
3: 81 percent / H2SO4
With sulfuric acid; In diethyl ether; ethanol;
1-<(S)-α-methylbenzylimino>-2,2-dimethylpropane
33978-37-9

1-<(S)-α-methylbenzylimino>-2,2-dimethylpropane

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide
75158-11-1

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 75 percent / ethanol
2: 81 percent / H2SO4
With sulfuric acid; In ethanol;
2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide
75158-11-1

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide

Conditions
Conditions Yield
2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide
75158-11-1

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide

L-tert-leucine methyl ester hydrochloride
63038-27-7,167223-43-0

L-tert-leucine methyl ester hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: 80 percent / hydrogen / 10percent Pd/C / acetic acid; methanol / 760 Torr / Ambient temperature
2: 35 percent / MnCl2*4H2O, 1N NaOH, leucine aminopeptidase / H2O / 40 h / 37 °C
3: 1) 0.5N NaOH / 1) dioxane, 16 h, RT, 2) ether
4: 52 percent / SOCl2 / 40 °C
With sodium hydroxide; thionyl chloride; hydrogen; manganese(ll) chloride; leucine aminopeptidase; palladium on activated charcoal; In methanol; water; acetic acid;
2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide
75158-11-1

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide

L-tert-Leucine
20859-02-3

L-tert-Leucine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 80 percent / hydrogen / 10percent Pd/C / acetic acid; methanol / 760 Torr / Ambient temperature
2: 35 percent / MnCl2*4H2O, 1N NaOH, leucine aminopeptidase / H2O / 40 h / 37 °C
With sodium hydroxide; hydrogen; manganese(ll) chloride; leucine aminopeptidase; palladium on activated charcoal; In methanol; water; acetic acid;
Multi-step reaction with 2 steps
1: 96 percent / H2 / 10percent Pd/C / aq. ethanol / 2280 Torr
2: 76 percent / conc. HCl / 100 °C
With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;
2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide
75158-11-1

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide

L-tyrosyl-D-alanyl-glycyl-L-phenylalanyl-t-butylglycine amide acetate

L-tyrosyl-D-alanyl-glycyl-L-phenylalanyl-t-butylglycine amide acetate

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1: 80 percent / hydrogen / 10percent Pd/C / acetic acid; methanol / 760 Torr / Ambient temperature
2: 60 percent / N-ethylmorpholine, 1-hydroxybenzotriazole, DCC / dimethylformamide
3: 87 percent / 0.1N HCl / formic acid / 0.33 h / Ambient temperature
4: 68 percent / N-ethylmorpholine, 1-hydroxybenztriazole, DCC / dimethylformamide / 1) 0 deg C, 1 h, 2) RT, 16 h
5: 1) CF3COOH / 1) 30 min, RT, 2) chromatography
With N-ethylmorpholine;; hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; formic acid; acetic acid; N,N-dimethyl-formamide;

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