7527-65-3

Basic information

• Product Name: 1-(cyclohexylamino)-2-methylpropan-2-ol
• CAS NO: 7527-65-3
• Molecular Formula: C₁₀H₂₁NO
• Molecular Weight: 171.2798
• Mol File: 7527-65-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 285.2°C at 760 mmHg
• Flash Point: 97.5°C
• Density: 0.94g/cm³
• Vapor Pressure: 0.000326mmHg at 25°C
• Refractive Index: 1.478
• CAS DataBase Reference: 1-(cyclohexylamino)-2-methylpropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(cyclohexylamino)-2-methylpropan-2-ol(7527-65-3)
• EPA Substance Registry System: 1-(cyclohexylamino)-2-methylpropan-2-ol(7527-65-3)

Safety Data

• Hazardous Substances Data: 7527-65-3(Hazardous Substances Data)

Usage

General Description

1-(cyclohexylamino)-2-methylpropan-2-ol, also known as CMPO, is a chemical compound used in the extraction and separation of various metals. It is a chelating ligand that is commonly used in nuclear reprocessing and in the extraction of actinide and lanthanide elements from aqueous solutions. CMPO has a high affinity for certain metal ions, allowing for selective extraction and separation processes. It is also used in the development of solvent extraction processes for the recovery of valuable metals from industrial and mining waste streams. CMPO is a versatile and important chemical in the field of metal extraction and recovery.

Upstream product

• 558-30-5 2-methyl-1,2-epoxypropane 
• 108-91-8 cyclohexylamine 
• 108-94-1 cyclohexanone 
• 5857-80-7 (Z)-N-(2-methylpropylidene)cyclohexanamine oxide 
• 25100-12-3 N-cyclohexylhydroxylamine hydrochloride 
• 7527-63-1 2,2-dimethyl-1-oxa-4-aza-spiro[4.5]decan-3-one 
• 2854-16-2 1-Amino-2-methyl-propan-2-ol 
• 1379226-90-0 C₁₀H₁₉NO 
• 100812-05-3 2,2-Dimethyl-propionic acid 2-[(E)-cyclohexylimino]-1,1-dimethyl-ethyl ester 

Downstream Products

• 500537-44-0 4-nitro-benzoic acid-[cyclohexyl-(3-hydroxy-isobutyl)-amide] 
• 854654-06-1 N-cyclohexyl-N-(β-hydroxy-isobutyl)-N'-phenyl-urea 
• 500537-46-2 N-cyclohexyl-N-(β-hydroxy-isobutyl)-benzamide 
• 500538-09-0 diphenyl-acetic acid-[cyclohexyl-(β-hydroxy-isobutyl)-amide] 

Relevant articles and documents

Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses

Over half a century since the description of the first antiviral drug, “old” re-emerging viruses and “new” emerging viruses still represent a serious threat to global health. Their high mutation rate and rapid selection of resistance toward common antiviral drugs, together with the increasing number of co-infections, make the war against viruses quite challenging. Herein we report a host-targeted approach, based on the inhibition of the lipid kinase PI4KIIIβ, as a promising strategy for inhibiting the replication of multiple viruses hijacking this protein. We show that bithiazole inhibitors of PI4KIIIβ block the replication of human rhinoviruses (hRV), Zika virus (ZIKV) and SARS-CoV-2 at low micromolar and sub-micromolar concentrations. However, while the anti-hRV/ZIKV activity can be directly linked to PI4KIIIβ inhibition, the role of PI4KIIIβ in SARS-CoV-2 entry/replication is debated.

IDO INHIBITORS

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Preparation of Vicinal N-Alkylamino Alcohols via Acylation-Rearrangement of Nitrones Followed by Hydride Reduction

Acylation-rearrangement of N-tert-butyl and N-cyclohexyl nitrones of cyclohexanecarboxaldehyde (1), n-butyraldehyde, isobutyraldehyde, 3-cyclohexenecarboxaldehyde, and α-methylpropionaldehyde gave α-pivaloyloxy imines, which underwent reduction with lithi