75302-98-6

Basic information

• Product Name: ACEMETACINTERT-BUTYLESTER
• Synonyms: ACEMETACINTERT-BUTYLESTER;2-TERT-BUTOXY-2-OXOETHYL [1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOL-3-YL]ACETATE
• CAS NO: 75302-98-6
• Molecular Formula: C₂₅H₂₆ClNO₆
• Molecular Weight: 471.93
• Mol File: 75302-98-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Vapor Pressure: 0Pa at 25℃
• CAS DataBase Reference: ACEMETACINTERT-BUTYLESTER(CAS DataBase Reference)
• NIST Chemistry Reference: ACEMETACINTERT-BUTYLESTER(75302-98-6)
• EPA Substance Registry System: ACEMETACINTERT-BUTYLESTER(75302-98-6)

Safety Data

• Hazardous Substances Data: 75302-98-6(Hazardous Substances Data)

Usage

General Description

ACEMETACIN is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and swelling. The chemical compound ACEMETACIN TERT-BUTYL ESTER is a derivative of ACEMETACIN with improved solubility and bioavailability. It is commonly used in pharmaceutical formulations to enhance the delivery and absorption of ACEMETACIN in the body. The TERT-BUTYL ESTER derivative is also known for its lower gastrointestinal side effects compared to the parent compound. Overall, ACEMETACIN TERT-BUTYL ESTER is a valuable pharmaceutical ingredient in the development of more effective and well-tolerated pain relief medications.

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 53-86-1 [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 
• 107-59-5 tert-Butyl chloroacetate 

Downstream Products

• 53-86-1 [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 
• 53164-05-9 acemetacin 
• 2504-32-7 O-Desmethyl-Indomethacin 

Relevant articles and documents

Preparation method of acemetacin

The invention discloses a preparation method of acemetacin. The preparation method comprises the following steps: (1) introducing hydrogen chloride into glacial acetic acid to prepare an acetic acid solution of hydrogen chloride; (2) adding acetic anhydride into the acetic acid solution of hydrogen chloride prepared in the step (1); (3) adding acemetacin tert-butyl ester into the hydrogen chloride-acetic acid-acetic anhydride mixed acidolysis solution obtained in the step (2), and stirring at a constant temperature; (4) after the reaction is finished, cooling, carrying out standing crystallization, filtering, and carrying out top-washing to obtain a crude product acemetacin; and (5) refining the crude product acemetacin to obtain the finished product acemetacin. The invention provides a preparation method of acemetacin, wherein the influence of moisture in raw materials on an acidolysis reaction of acemetacin tert-butyl ester is eliminated on the premise of adopting the existing equipment, so that the product yield is increased, the production cost is lowered, and the economic benefit is improved.