75640-14-1

Basic information

• Product Name: 5-(2-methoxyphenyl)-1,3-diphenyl-1H-pyrazole
• Synonyms: 5-(2-methoxyphenyl)-1,3-diphenyl-1H-pyrazole
• CAS NO: 75640-14-1
• Molecular Weight: 326.398
• Mol File: 75640-14-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5-(2-methoxyphenyl)-1,3-diphenyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-methoxyphenyl)-1,3-diphenyl-1H-pyrazole(75640-14-1)
• EPA Substance Registry System: 5-(2-methoxyphenyl)-1,3-diphenyl-1H-pyrazole(75640-14-1)

Safety Data

• Hazardous Substances Data: 75640-14-1(Hazardous Substances Data)

Upstream product

• 7245-44-5 5-(2-methoxyphenyl)-1,3-diphenyl-2-pyrazoline 
• 119824-80-5 1,3-diphenyl-5-orthomethoxyphenyl pyrazole-4-carboxylic acid 
• 135-02-4 ortho-anisaldehyde 
• 22965-99-7 (E)-3-(2-methoxylphenyl)-1-phenylprop-2-en-1-one 
• 767-91-9 1-ethynyl-2-methoxybenzene 
• 100-52-7 benzaldehyde 
• 100-63-0 phenylhydrazine 
• 68235-45-0 2,3-epoxy-3-(2-metoxyphenyl)-1-phenylpropan-1-one 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 100008-84-2 1,3-diphenyl-4-oxo-1H-benzopyrano<4,3-c>pyrazole 
• 119824-79-2 1,3-diphenyl-5-orthomethoxyphenyl-4-methoxycarbonyl pyrazole 
• 119824-78-1 1,3-diphenyl-5-orthomethoxyphenyl-4-methoxycarbonyl-pyrazoline 
• 93232-47-4 1,3-diphenyl-3a,9b-dihydro-4-oxo-1H-benzopyrano<4,3-c>pyrazole 
• 91-64-5 coumarin 

Downstream Products

• 75640-15-2 3-bromo-2-phenylpyrazolo<1,5-f>phenanthridine 
• 55042-91-6 2-phenylpyrazolo<1,5-f>phenanthridine 

Relevant articles and documents

PTSA-catalyzed Mannich-type-cyclization-oxidation tandem reactions: One-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes

A convenient one-pot Mannich-type-cyclization-oxidation tandem process has been developed for the synthesis of 1,3,5-trisubstituted pyrazoles derivatives from aldehydes, hydrazines and alkynes using p-toluenesulfonic acid monohydrate (PTSA) as a multifunctional catalyst. This method provides a flexible and rapid route to 1,3,5-trisubstituted pyrazoles.

Synthesis and characterization of 1,3,5-triarylpyrazol-4-ols and 3,5-diarylisoxazol-4-ols from chalcones and theoretical studies of the stability of pyrazol-4-ol toward acid dehydration

The synthesis of diverse pyrazol-4-ol and isoxazole-4-ol heterocycles involving only 3 reaction steps is reported in this study. However, the synthesis of carboxamide pyrazol-4-ol has failed in the conditions used in the synthesis, acid methanol solution. The carboxamide pyrazol-4-ol decomposes via dehydration, forming the respective pyrazol. Theoretical calculations were used to elucidate the dehydration reaction. We have found a mechanism for acid-catalyzed dehydration that can explain the experimental observations. The calculated free energy profile for acid-catalyzed dehydration of the carboxamide pyrazol-4-ol and phenylpyrazole-4-ol point out that the latter is more stable in relation dehydration, with a dehydration rate 100 times smaller in acid methanol solution.

Solvent-free synthesis of 1, 3-diphenyl-5-arylpyrazole derivatives

The synthesis of 1, 3-diphenyl-5-arylpyrazoles via the reactions of 2, 3-epoxy-1-phenyl-3-aryl-1-propanones with phenylhydrazine was carried out in 48-84% yields at 230 °C under solvent-free condition within 1.5 h. This method provides several advantages