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75853-18-8

75853-18-8

Identification

  • Product Name:Benzenemethanol,2,3-difluoro-

  • CAS Number: 75853-18-8

  • EINECS:

  • Molecular Weight:144.121

  • Molecular Formula: C7H6F2O

  • HS Code:29062990

  • Mol File:75853-18-8.mol

Synonyms:(2,3-Difluorophenyl)methanol;(2,3-Difluorophenyl)methan-1-ol;2,3-Difluoro benzylalcohol;AC1Q7BXL;AC1L9KJ4;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
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  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:2,3-Difluorobenzyl alcohol
  • Packaging:250mg
  • Price:$ 55
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:2,3-Difluorobenzyl Alcohol >98.0%(GC)
  • Packaging:25g
  • Price:$ 190
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:2,3-Difluorobenzyl Alcohol >98.0%(GC)
  • Packaging:5g
  • Price:$ 64
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2,3-Difluorobenzyl alcohol 98%
  • Packaging:5 g
  • Price:$ 36
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2,3-Difluorobenzyl alcohol 98%
  • Packaging:1 g
  • Price:$ 16
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2,3-Difluorobenzyl alcohol 94%
  • Packaging:5g
  • Price:$ 86.1
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2,3-Difluorobenzyl alcohol 95%
  • Packaging:5g
  • Price:$ 29
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2,3-Difluorobenzyl alcohol 95%
  • Packaging:25g
  • Price:$ 96
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  • Manufacture/Brand:Crysdot
  • Product Description:2,3-Difluorobenzyl alcohol 97%
  • Packaging:100g
  • Price:$ 248
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  • Manufacture/Brand:Chemenu
  • Product Description:2,3-Difluorobenzyl alcohol 95+%
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Relevant articles and documentsAll total 2 Articles be found

Dibenzo seven-membered ring derivative as well as preparation method and application thereof

-

, (2021/03/31)

The invention relates to a dibenzo seven-membered ring derivative as well as a preparation method and application thereof. The chemical structure of the dibenzo seven-membered ring derivative is shownas a formula (I), and X1 and X2 are respectively and independently selected from H, F, Cl, Br or I. The preparation method has easily available raw materials, and can ensure continuous supply and production; the raw materials are cheap and have the cost advantage; and thiophenol or sodium thiophenol is not used, so that the method is more environment-friendly and is also beneficial to the body health of related personnel. 7,8-difluorodibenzo[b,e]thiazepine-11(6H)-one as one of the products can further react to obtain 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol, and the 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol can be used as an important intermediate for preparing a drug baloxavir, so that baloxavir preparation cost is reduced.

9-(2-fluorobenzyl)-6-(alkylamino)-9H-purines. A new class of anticonvulsant agents

Kelley,Krochmal,Linn,McLean,Soroko

, p. 1005 - 1009 (2007/10/02)

Several substituted aryl and 6-alkylamino analogues of the anticonvulsant purine 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats. Derivatives with a second fluoro substituent in the 5- or 6-position of the aryl moiety were very active with ip ED50's that ranged from 2 to 4 mg/kg. Congeners in which the purine 6-substituent was varied among a number of alkylamino groups possessed potent activity against MES that was comparable to or several times better than phenytoin.

Process route upstream and downstream products

Process route

2,3-difluorobenzoic acid
4519-39-5

2,3-difluorobenzoic acid

(2,3-difluoro-phenyl)-methanol
75853-18-8

(2,3-difluoro-phenyl)-methanol

Conditions
Conditions Yield
With diborane; In tetrahydrofuran; for 1.5h;
40%
ortho-difluorobenzene
367-11-3

ortho-difluorobenzene

(2,3-difluoro-phenyl)-methanol
75853-18-8

(2,3-difluoro-phenyl)-methanol

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / 2 h / -70 °C
1.2: 2 h
2.1: sodium tetrahydroborate / methanol / 4 h / 5 - 30 °C
With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; methanol;
(2,3-difluoro-phenyl)-methanol
75853-18-8

(2,3-difluoro-phenyl)-methanol

2,3-difluorobenzyl bromide
113211-94-2

2,3-difluorobenzyl bromide

Conditions
Conditions Yield
With phosphorus tribromide; In toluene; at 100 ℃; for 1h;
61%
With phosphorus tribromide; In diethyl ether; at -10 ℃; for 1.25h;
20 g
4-[2-(4-bromo-phenyl)-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-yl]-butyric acid t-butyl ester
1354910-14-7

4-[2-(4-bromo-phenyl)-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-yl]-butyric acid t-butyl ester

(2,3-difluoro-phenyl)-methanol
75853-18-8

(2,3-difluoro-phenyl)-methanol

4-{2-[4-(2,3-difluoro-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-yl}-butyric acid t-butyl ester
1354910-15-8

4-{2-[4-(2,3-difluoro-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-yl}-butyric acid t-butyl ester

Conditions
Conditions Yield
With caesium carbonate; 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; palladium diacetate; In toluene; at 70 ℃; for 16h;
70%
(2,3-difluoro-phenyl)-methanol
75853-18-8

(2,3-difluoro-phenyl)-methanol

2,2',3,3'-tetrafluoro-1,2-diphenylethanone

2,2',3,3'-tetrafluoro-1,2-diphenylethanone

Conditions
Conditions Yield
With Zn0.6In2S3.6; In acetonitrile; at 20 ℃; for 36h; Inert atmosphere; Sealed tube; Irradiation;
75.5%
(2,3-difluoro-phenyl)-methanol
75853-18-8

(2,3-difluoro-phenyl)-methanol

norcantharidin
29745-04-8

norcantharidin

C<sub>15</sub>H<sub>14</sub>F<sub>2</sub>O<sub>5</sub>

C15H14F2O5

Conditions
Conditions Yield
With dmap; In dichloromethane; at 60 ℃; for 14h; Sealed tube; Inert atmosphere;
97%
7-hydroxy-2,5-dimethylpyrazolo[1,5-a]pyridine-3-carboxylate ethyl

7-hydroxy-2,5-dimethylpyrazolo[1,5-a]pyridine-3-carboxylate ethyl

(2,3-difluoro-phenyl)-methanol
75853-18-8

(2,3-difluoro-phenyl)-methanol

ethyl 7-[(2,3-difluorophenyl)methoxy]-2,5-dimethylpyrazolo[1,5-a]pyridine-3-carboxylate

ethyl 7-[(2,3-difluorophenyl)methoxy]-2,5-dimethylpyrazolo[1,5-a]pyridine-3-carboxylate

Conditions
Conditions Yield
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 1h;
67%
(2,3-difluoro-phenyl)-methanol
75853-18-8

(2,3-difluoro-phenyl)-methanol

1-(chloromethyl)-2,3-difluorobenzene
446-57-1

1-(chloromethyl)-2,3-difluorobenzene

Conditions
Conditions Yield
With pyridine; thionyl chloride; at 40 ℃; Reagent/catalyst; Temperature;
93.1%
3-chloro-7,8-dihydro-1H,6H,9H-6,8a-ethanopyrrolo[1',2':3,4]imidazolo[1,2-c]pyrimidin-1-one

3-chloro-7,8-dihydro-1H,6H,9H-6,8a-ethanopyrrolo[1',2':3,4]imidazolo[1,2-c]pyrimidin-1-one

(2,3-difluoro-phenyl)-methanol
75853-18-8

(2,3-difluoro-phenyl)-methanol

C<sub>18</sub>H<sub>17</sub>F<sub>2</sub>N<sub>3</sub>O<sub>2</sub>

C18H17F2N3O2

Conditions
Conditions Yield
(2,3-difluoro-phenyl)-methanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.333333h;
3-chloro-7,8-dihydro-1H,6H,9H-6,8a-ethanopyrrolo[1',2':3,4]imidazolo[1,2-c]pyrimidin-1-one; In N,N-dimethyl-formamide; mineral oil; for 1h;
43%
C<sub>9</sub>H<sub>10</sub>ClN<sub>3</sub>O<sub>2</sub>

C9H10ClN3O2

(2,3-difluoro-phenyl)-methanol
75853-18-8

(2,3-difluoro-phenyl)-methanol

C<sub>16</sub>H<sub>15</sub>F<sub>2</sub>N<sub>3</sub>O<sub>3</sub>

C16H15F2N3O3

Conditions
Conditions Yield
(2,3-difluoro-phenyl)-methanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.0833333h;
C9H10ClN3O2; In N,N-dimethyl-formamide; mineral oil; for 1h;
26.5%

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