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7612-98-8

7612-98-8

7612-98-8

Identification

Synonyms:Benzenamine,4-[(4-isothiocyanatophenyl)azo]-N,N-dimethyl- (9CI); Isothiocyanic acid,p-[[p-(dimethylamino)phenyl]azo]phenyl ester (6CI,7CI,8CI); Aniline,p-[(p-isothiocyanatophenyl)azo]-N,N-dimethyl- (8CI);4-Dimethylamino-4'-isothiocyanatoazobenzene;4-Dimethylaminophenylazophenyl-4'-isothiocyanate;4-N,N-Dimethylaminoazobenzene-4'-isothiocyanate;4'-Dimethylaminoazobenzene-4-isothiocyanate; DABITC

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Chemical Properties

  • Appearance/Colour:Rust crystalline powder

  • Melting Point: 167-171oC(lit.)

  • Boiling Point: 466.2°C at 760 mmHg

  • Flash Point:235.7°C

  • Density: 1.13g/cm3

  • Solubility:dioxane: 20 mg/mL, clear, red

  • Vapor Pressure: 7.25E-09mmHg at 25°C

  • Refractive Index: 1.5700 (estimate)

  • PKA: 3.28±0.10(Predicted)

  • Sensitive: Moisture Sensitive

  • BRN: 752568

  • PSA: 72.41000

  • LogP: 4.90230

Safety information and MSDS view more

  • Pictogram(s):Xn

  • Hazard Codes:Xn

  • Signal Word:Danger

  • Hazard Statement:H317 May cause an allergic skin reactionH334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
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  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:4-(4-Isothiocyanatophenylazo)-N,N-dimethylaniline
  • Packaging:100mg
  • Price:$ 165
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:4-(Dimethylamino)azobenzene 4'-Isothiocyanate >95.0%(T)
  • Packaging:100mg
  • Price:$ 42
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-(N,N-Dimethylamino)azobenzene-4'-isothiocyanate
  • Packaging:250 mg
  • Price:$ 35
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-(N,N-Dimethylamino)azobenzene-4'-isothiocyanate
  • Packaging:1 g
  • Price:$ 111
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-(4-Isothiocyanatophenylazo)-N,N-dimethylaniline 97%
  • Packaging:1g
  • Price:$ 316
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-(4-Isothiocyanatophenylazo)-N,N-dimethylaniline 97%
  • Packaging:250mg
  • Price:$ 110
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:4-(N,N-Dimethylamino)azobenzene-4'-isothiocyanate
  • Packaging:500mg
  • Price:$ 95
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:4-(N,N-Dimethylamino)azobenzene-4'-isothiocyanate
  • Packaging:1g
  • Price:$ 160
  • Delivery:In stock
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  • Manufacture/Brand:Chem-Impex
  • Product Description:4-(4-Isothiocyanatophenylazo)-N,N-dimethylaniline,≥96.5%(HPLC),suitableforHematology&Histology ≥96.5%(HPLC)
  • Packaging:250MG
  • Price:$ 108.33
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:4-(4-ISOTHIOCYANATOPHENYLAZO)-N,N-DIMETHYLANILINE 95.00%
  • Packaging:500MG
  • Price:$ 723.03
  • Delivery:In stock
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Relevant articles and documentsAll total 3 Articles be found

High sensitivity sequence analysis of peptides and proteins by 4 NN dimethylaminoazobenzene 4' isothiocyanate

Chang

, p. 517 - 520 (1977)

-

Azo compounds reducing formation and toxicity of amyloid beta aggregation intermediates

-

, (2011/10/12)

The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.

Dual resonance energy transfer nucleic acid probes

-

, (2008/06/13)

Dual nucleic acid probes with resonance energy transfer moieties are provided. In particular, fluorescent or luminescent resonance energy transfer moieties are provided on hairpin stem-loop molecular beacon probes that hybridize sufficiently near each other on a subject nucleic acid, e.g. mRNA, to generate an observable interaction. The invention also provides lanthanide chelate luminescent resonance energy transfer moieties on linear and stem-loop probes that hybridize sufficiently near each other on a subject nucleic acid to generate an observable interaction. The invention thereby provides detectable signals for rapid, specific and sensitive hybridization determination in vivo. The probes are used in methods of detection of nucleic acid target hybridization for the identification and quantification of tissue and cell-specific gene expression levels, including response to external stimuli, such as drug candidates, and genetic variations associated with disease, such as cancer.

Process route upstream and downstream products

Process route

4-N,N-dimethylamino-azobenzene-4'-isothiocyanate
7612-98-8

4-N,N-dimethylamino-azobenzene-4'-isothiocyanate

Conditions
Conditions Yield
4-Amino-4'-dimethylamino-azobenzol/CHCl3, CSCl2/CHCl3, CaCO3/Wasser;
4-Amino-4'-dimethylaminoazobenzol/CHCl3, CSCl2/CaCO3/CHCl3/Wasser;
4-Dimethylamino-4'-aminoazobenzol, CSCl2;
4-N,N-Dimethylamino-4'-aminoazobenzol, CSCl2;
4-(4-isothiocyanatophenylazo)-N,N-dimethylaniline
7612-98-8

4-(4-isothiocyanatophenylazo)-N,N-dimethylaniline

Conditions
Conditions Yield
4-Dimethylamino-4'-amino-azobenzol, Gemisch v. aq. Thiophosgen, Dichloraethan-CHCl3 (1:1), Kuehlen;
N-(2-aminoethyl)-3,4,5-tris(dodecyloxy)benzamide
912275-84-4

N-(2-aminoethyl)-3,4,5-tris(dodecyloxy)benzamide

4-N,N-dimethylamino-azobenzene-4'-isothiocyanate
7612-98-8

4-N,N-dimethylamino-azobenzene-4'-isothiocyanate

C<sub>62</sub>H<sub>100</sub>N<sub>4</sub>O<sub>4</sub>S

C62H100N4O4S

Conditions
Conditions Yield
In tetrahydrofuran; at 90 ℃; for 12h;
70.5%
4-N,N-dimethylamino-azobenzene-4'-isothiocyanate
7612-98-8

4-N,N-dimethylamino-azobenzene-4'-isothiocyanate

sodium N-[2-N[(S-(4-azido-4-deoxy-β-D-glucopyranosyl)-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl)-2-thioacetyl]aminoethyl]-1-naphthylamine-5-sulfonate

sodium N-[2-N[(S-(4-azido-4-deoxy-β-D-glucopyranosyl)-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl)-2-thioacetyl]aminoethyl]-1-naphthylamine-5-sulfonate

sodium N-[2-N[(S-(4-deoxy-4-dimethylaminophenylazophenylthioureido-β-D-glucopyranosyl)-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-)-2-thioacetyl]aminoethyl]-1-.

sodium N-[2-N[(S-(4-deoxy-4-dimethylaminophenylazophenylthioureido-β-D-glucopyranosyl)-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-)-2-thioacetyl]aminoethyl]-1-.

Conditions
Conditions Yield
sodium N-[2-N[(S-(4-azido-4-deoxy-β-D-glucopyranosyl)-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-β-D-glucopyranosyl)-2-thioacetyl]aminoethyl]-1-naphthylamine-5-sulfonate; With pyridine; hydrogen sulfide; In water; at 20 ℃; for 2h;
4-N,N-dimethylamino-azobenzene-4'-isothiocyanate; With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 40 ℃; for 12h; Further stages.;
70%
(RS)-atenolol
29122-68-7

(RS)-atenolol

4-N,N-dimethylamino-azobenzene-4'-isothiocyanate
7612-98-8

4-N,N-dimethylamino-azobenzene-4'-isothiocyanate

2-(4-(3-(3-(4''-((4''-(dimethylamino)phenyl)diazenyl)phenyl)-1-isopropylthioureido)-2-hydroxypropoxy)phenyl)acetamide

2-(4-(3-(3-(4''-((4''-(dimethylamino)phenyl)diazenyl)phenyl)-1-isopropylthioureido)-2-hydroxypropoxy)phenyl)acetamide

Conditions
Conditions Yield
In acetonitrile; at 80 ℃;
0.91%
[2,2’-bipyridine]-4-amine
14151-21-4

[2,2’-bipyridine]-4-amine

4-(4-isothiocyanatophenylazo)-N,N-dimethylaniline
7612-98-8

4-(4-isothiocyanatophenylazo)-N,N-dimethylaniline

1-[2,2']bipyridinyl-4-yl-3-[4-(4-dimethylamino-phenylazo)-phenyl]-thiourea

1-[2,2']bipyridinyl-4-yl-3-[4-(4-dimethylamino-phenylazo)-phenyl]-thiourea

Conditions
Conditions Yield
In tetrahydrofuran; at 40 ℃; for 72h; under 4500360 Torr;
47%
4-(4-isothiocyanatophenylazo)-N,N-dimethylaniline
7612-98-8

4-(4-isothiocyanatophenylazo)-N,N-dimethylaniline

1,3,5-triethyl-2,4,6-tris(aminomethyl)benzene
149525-65-5

1,3,5-triethyl-2,4,6-tris(aminomethyl)benzene

1,3,5-triethyl-2,4,6-tris(4-dimethylamino-4-phenylazothioureidomethyl)benzene

1,3,5-triethyl-2,4,6-tris(4-dimethylamino-4-phenylazothioureidomethyl)benzene

Conditions
Conditions Yield
In tetrahydrofuran; at 20 ℃; for 72h; Inert atmosphere;
87%
histamine
51-45-6

histamine

4-N,N-dimethylamino-azobenzene-4'-isothiocyanate
7612-98-8

4-N,N-dimethylamino-azobenzene-4'-isothiocyanate

1-[4-(4-dimethylamino-phenylazo)-phenyl]-3-[2-(1<i>H</i>-imidazol-4-yl)-ethyl]-thiourea

1-[4-(4-dimethylamino-phenylazo)-phenyl]-3-[2-(1H-imidazol-4-yl)-ethyl]-thiourea

Conditions
Conditions Yield
With sodium hydrogencarbonate; In acetone; for 0.166667h; Heating;
100%
With sodium hydrogencarbonate; In acetone; at 30 - 100 ℃; Kinetics; Product distribution;
4-(4-isothiocyanatophenylazo)-N,N-dimethylaniline
7612-98-8

4-(4-isothiocyanatophenylazo)-N,N-dimethylaniline

rac-3-(N-methyl-N-(tert-butyloxycarbonyl)amino)-1-phenylpropylamine
244059-09-4

rac-3-(N-methyl-N-(tert-butyloxycarbonyl)amino)-1-phenylpropylamine

(3-{3-[4-(4-dimethylamino-phenylazo)-phenyl]-thioureido}-3-phenyl-propyl)-methyl-carbamic acid <i>tert</i>-butyl ester

(3-{3-[4-(4-dimethylamino-phenylazo)-phenyl]-thioureido}-3-phenyl-propyl)-methyl-carbamic acid tert-butyl ester

Conditions
Conditions Yield
With sodium hydride; Yield given; Multistep reaction; 1.) THF, 15 min, 2.) THF, RT, 16 h;
4-(4-isothiocyanatophenylazo)-N,N-dimethylaniline
7612-98-8

4-(4-isothiocyanatophenylazo)-N,N-dimethylaniline

(2R,3S)-ethyl-3β-tropanol-2β-carboxylate

(2R,3S)-ethyl-3β-tropanol-2β-carboxylate

(1S,2S,3R,5R)-3-[4-(4-Dimethylamino-phenylazo)-phenylthiocarbamoyloxy]-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid ethyl ester

(1S,2S,3R,5R)-3-[4-(4-Dimethylamino-phenylazo)-phenylthiocarbamoyloxy]-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid ethyl ester

Conditions
Conditions Yield
With sodium hydride; Yield given; Multistep reaction; 1.) THF, 15 min, 2.) THF, RT, 16 h;

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  • Finetech Industry Limited
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  • Antimex Chemical Limied
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  • Debye Scientific
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  • Amadis Chemical Co., Ltd.
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