761440-22-6

Basic information

• Product Name: 1-(3-Methoxy-4-nitrophenyl)piperidin-4-ol
• Synonyms: 1-(3-Methoxy-4-nitrophenyl)piperidin-4-ol;1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinol
• CAS NO: 761440-22-6
• Molecular Formula: C₁₂H₁₆N₂O₄
• Molecular Weight: 252.26644
• Mol File: 761440-22-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 458.8°C at 760 mmHg
• Flash Point: 231.2°C
• Appearance: /
• Density: 1.296g/cm³
• Vapor Pressure: 3.28E-09mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(3-Methoxy-4-nitrophenyl)piperidin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Methoxy-4-nitrophenyl)piperidin-4-ol(761440-22-6)
• EPA Substance Registry System: 1-(3-Methoxy-4-nitrophenyl)piperidin-4-ol(761440-22-6)

Safety Data

• Hazardous Substances Data: 761440-22-6(Hazardous Substances Data)

Usage

General Description

1-(3-Methoxy-4-nitrophenyl)piperidin-4-ol is a chemical compound with the molecular formula C13H17NO4. It is a piperidine derivative with a phenyl ring substituted with a methoxy and nitro group. The compound has a piperidin-4-ol moiety, which is a six-membered heterocyclic ring with a nitrogen atom. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. It has potential pharmacological properties and can be utilized as a starting material in the development of new drugs. The compound's structure and properties make it a versatile and valuable component in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C12H16N2O4/c1-18-12-8-9(2-3-11(12)14(16)17)13-6-4-10(15)5-7-13/h2-3,8,10,15H,4-7H2,1H3

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 

Downstream Products

• 761440-64-6 1-(3-methoxy-4 nitrophenyl)piperidin-4-one 
• 761440-66-8 4-(2-ethoxy-ethoxy)-1-(3-methoxy-4-nitro-phenyl)-piperidine 
• 1197953-54-0 5-chloro-N⁴-[2-(dimethylphosphonyl)phenyl]-N²-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine 
• 761440-65-7 1-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine 
• 1089279-91-3 1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidine-4-amine 
• 1089279-90-2 1-(3-methoxy-4-nitrophenyl)-N,N-dimethylpiperidine-4-amine 
• 1356962-95-2 N-cyclopropyl-1-(3-methoxy-4-nitrophenyl)piperidin-4-amine 
• 761440-87-3 1-(4-amino-3-methoxyphenyl)piperidin-4-ol 

Relevant articles and documents

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Nitric oxide donating anilinopyrimidines: Synthesis and biological evaluation as EGFR inhibitors

To search for potent nitric oxide (NO) donating epidermal growth factor receptor (EGFR) inhibitors, a series of phenylsulfonylfuroxan-based anilinopyrimidines 10a-h were synthesized and biologically evaluated. Compounds 10f-h exhibited potent inhibitory activity against EGFR L858R/T790M and were as potent as WZ4002 in inhibition of H1975 cells harboring EGFR L858R/T790M. Additionally, 10h produced high levels of NO in H1975 cells but not in normal human cells, and its antiproliferative activity was diminished by hemoglobin, an NO scavenger. Furthermore, 10h inhibited EGFR activation and downstream signaling in H1975 cells. These results suggest that the strong antiproliferative activity of 10h could be attributed to the synergic effects of high levels of NO production and inhibition of EGFR and downstream signaling in the cancer cells.