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Cas Database

761440-64-6

761440-64-6

Identification

  • Product Name:1-(3-methoxy-4-nitrophenyl)piperidin-4-one

  • CAS Number: 761440-64-6

  • EINECS:1592732-453-0

  • Molecular Weight:250.254

  • Molecular Formula: C12H14N2O4

  • HS Code:2933399090

  • Mol File:761440-64-6.mol

Synonyms:1-(3-methoxy-4-nitro-phenyl)piperidin-4-one;methoxynitrophenyltetrahydropyridinone;1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinone;1-(3-methoxy-4-nitrophenyl)tetrahydro-4(1H)-pyridinone;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:1-(3-Methoxy-4-nitrophenyl)-4-piperidinone
  • Packaging:50mg
  • Price:$ 45
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynChem
  • Product Description:1-(3-METHOXY-4-NITROPHENYL)PIPERIDIN-4-ONE 95%
  • Packaging:5 g
  • Price:$ 465
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynChem
  • Product Description:1-(3-METHOXY-4-NITROPHENYL)PIPERIDIN-4-ONE 95%
  • Packaging:1 g
  • Price:$ 145
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:1-(3-Methoxy-4-nitrophenyl)tetrahydro-4(1H)-pyridinone >95%
  • Packaging:5g
  • Price:$ 524
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:1-(3-Methoxy-4-nitrophenyl)tetrahydro-4(1H)-pyridinone >95%
  • Packaging:1g
  • Price:$ 228
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:1-(3-Methoxy-4-nitrophenyl)tetrahydro-4(1H)-pyridinone >95%
  • Packaging:500mg
  • Price:$ 181
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Crysdot
  • Product Description:1-(3-Methoxy-4-nitrophenyl)piperidin-4-one 95+%
  • Packaging:5g
  • Price:$ 392
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:1-(3-Methoxy-4-nitrophenyl)tetrahydro-4(1H)-pyridinone 95%
  • Packaging:5g
  • Price:$ 371
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:1-(3-METHOXY-4-NITROPHENYL)TETRAHYDRO-4(1H)-PYRIDINONE 95.00%
  • Packaging:10G
  • Price:$ 1585.35
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:1-(3-METHOXY-4-NITROPHENYL)TETRAHYDRO-4(1H)-PYRIDINONE 95.00%
  • Packaging:5G
  • Price:$ 1115.96
  • Delivery:In stock
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Relevant articles and documentsAll total 14 Articles be found

Synthesis method of Brigatinib intermediate

-

Paragraph 0034-0038; 0044-0051, (2021/06/26)

The invention discloses a synthesis method of a Brigatinib intermediate. The Brigatinib intermediate is 2-methoxy-4-(4-(4-methyl piperazine-1-yl) piperidine-1-yl) aniline (I). The synthesis method comprises the following steps: taking 5-fluoro-2-nitroanis

Preparation method and crystal form of deuterated diphenyl amino pyrimidine compound

-

Paragraph 0340-0344, (2019/04/27)

The present invention discloses a preparation method and a crystal form of a compound shown in the formula (A) and also discloses a pharmaceutical composition comprising the crystal form of the compound shown in the formula (A) and a method for treating A

Substituted diaminopyrimidine compound

-

Paragraph 0229-0234, (2019/07/04)

The present invention provides a substituted diaminopyrimidine compound represented by a formula (I), or a pharmaceutically acceptable salt, a crystal form, a prodrug, a metabolite, a hydrate, a solvate, a stereoisomer or an isotope derivative thereof, as well as a pharmaceutical composition and uses thereof. The compound provided by the invention can be used for treating ALK-mediated related diseases, such as non-small cell lung cancer, breast cancer, neural tumor, esophageal cancer, soft tissue cancer, lymphoma and leukemia.

DEUTERIUM-MODIFIED BRIGATINIB DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND USE THEREOF

-

, (2018/10/15)

The present invention relates to the field of pharmaceutical chemistry, and relates to a deuterium-modified Brigatinib derivative, preparation method thereof, pharmaceutical composition containing the same and the uses of the deuterium-modified Brigatinib derivative and the pharmaceutical composition thereof in preparing a medicament for treating the disease mediated by anaplastic lymphoma kinase. The deuterium-modified Brigatinib derivative of the present invention has an excellent inhibitory activity on anaplastic lymphoma kinase and has better pharmacodynamic or pharmacokinetic properties relative to Brigatinib.

2,4-dibasic miazines compound

-

, (2017/08/29)

The invention belongs to the field of medical chemistry, relates to a 2,4-dibasic miazines compound and specifically relates to a compound shown as formula (I) or a pharmaceutically acceptable salt thereof, a drug compound thereof and an application thereof in treating EGFR or/and ALK mediated diseases.

Process route upstream and downstream products

Process route

1-(3-methoxy-4-nitrophenyl)piperidin-4-ol
761440-22-6

1-(3-methoxy-4-nitrophenyl)piperidin-4-ol

1-(3-methoxy-4 nitrophenyl)piperidin-4-one
761440-64-6

1-(3-methoxy-4 nitrophenyl)piperidin-4-one

Conditions
Conditions Yield
1-(3-methoxy-4-nitrophenyl)piperidin-4-ol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.25h;
With triethylamine; In dichloromethane; at -78 - 20 ℃;
97%
With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;
97%
1-(3-methoxy-4-nitrophenyl)piperidin-4-ol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; Inert atmosphere;
With triethylamine; In dichloromethane; at -78 - 20 ℃;
97%
With pyridine; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In benzene;
97%
With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 4.5h;
80%
With water; sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1.5h;
79%
With Dess-Martin periodane; In dichloromethane; for 3h;
70.76%
4-fluoro-2-methoxy-1-nitrobenzene
448-19-1

4-fluoro-2-methoxy-1-nitrobenzene

4-piperidone hydrochloride
41979-39-9

4-piperidone hydrochloride

1-(3-methoxy-4 nitrophenyl)piperidin-4-one
761440-64-6

1-(3-methoxy-4 nitrophenyl)piperidin-4-one

Conditions
Conditions Yield
With tetrabutylammomium bromide; potassium carbonate; In water; N,N-dimethyl-formamide; at 75 - 80 ℃; for 20h; Temperature; Reagent/catalyst; Solvent;
90%
With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; Inert atmosphere;
84.8%
With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃;
78.9%
With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 24h;
76.72%
With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;
74.6%
With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 70 ℃; for 20h;
61%
With potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 18h;
42.4%
4-fluoro-2-methoxy-1-nitrobenzene
448-19-1

4-fluoro-2-methoxy-1-nitrobenzene

4-piperidone monohydrochloride monohydrate
40064-34-4,320589-77-3

4-piperidone monohydrochloride monohydrate

1-(3-methoxy-4 nitrophenyl)piperidin-4-one
761440-64-6

1-(3-methoxy-4 nitrophenyl)piperidin-4-one

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; Inert atmosphere;
84%
4-fluoro-2-methoxy-1-nitrobenzene
448-19-1

4-fluoro-2-methoxy-1-nitrobenzene

1-(3-methoxy-4 nitrophenyl)piperidin-4-one
761440-64-6

1-(3-methoxy-4 nitrophenyl)piperidin-4-one

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: potassium carbonate / dimethyl sulfoxide / 1 h / 90 °C
2: Dess-Martin periodane / dichloromethane / 4.5 h / 0 - 20 °C
With potassium carbonate; Dess-Martin periodane; In dichloromethane; dimethyl sulfoxide;
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 70 °C
2: Dess-Martin periodane / dichloromethane / 3 h
With potassium carbonate; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide;
4-HYDROXYPIPERIDINE
5382-16-1

4-HYDROXYPIPERIDINE

1-(3-methoxy-4 nitrophenyl)piperidin-4-one
761440-64-6

1-(3-methoxy-4 nitrophenyl)piperidin-4-one

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: potassium carbonate / dimethyl sulfoxide / 1 h / 90 °C
2: Dess-Martin periodane / dichloromethane / 4.5 h / 0 - 20 °C
With potassium carbonate; Dess-Martin periodane; In dichloromethane; dimethyl sulfoxide;
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 70 °C
2: Dess-Martin periodane / dichloromethane / 3 h
With potassium carbonate; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide;
5-fluoro-2-nitrophenol
446-36-6

5-fluoro-2-nitrophenol

1-(3-methoxy-4 nitrophenyl)piperidin-4-one
761440-64-6

1-(3-methoxy-4 nitrophenyl)piperidin-4-one

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 0.5 h / 20 °C / Inert atmosphere
1.2: 60 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 75 °C
With potassium carbonate; In N,N-dimethyl-formamide; acetone;
1-methyl-piperazine
109-01-3

1-methyl-piperazine

1-(3-methoxy-4 nitrophenyl)piperidin-4-one
761440-64-6

1-(3-methoxy-4 nitrophenyl)piperidin-4-one

1-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine
761440-65-7

1-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

Conditions
Conditions Yield
1-methyl-piperazine; 1-(3-methoxy-4 nitrophenyl)piperidin-4-one; In dichloromethane; at 0 - 20 ℃; for 4h;
With sodium tris(acetoxy)borohydride; at 20 ℃; for 24h;
91%
1-methyl-piperazine; 1-(3-methoxy-4 nitrophenyl)piperidin-4-one; In 1,2-dichloro-ethane; for 0.5h;
With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;
73.2%
With formic acid; trimethyl orthoformate; In acetonitrile; at 110 ℃; for 1h; Microwave irradiation;
60.68%
With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In 1,2-dichloro-ethane;
1-methyl-piperazine
109-01-3

1-methyl-piperazine

1-(3-methoxy-4 nitrophenyl)piperidin-4-one
761440-64-6

1-(3-methoxy-4 nitrophenyl)piperidin-4-one

2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperazinyl]aniline hydrochloride

2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperazinyl]aniline hydrochloride

Conditions
Conditions Yield
1-methyl-piperazine; 1-(3-methoxy-4 nitrophenyl)piperidin-4-one; With acetic acid; In tetrahydrofuran; at 30 ℃; for 8h;
With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 50 - 55 ℃; for 20h; under 4500.45 - 5250.53 Torr; Reagent/catalyst; Temperature; Solvent;
79%
1-(3-methoxy-4 nitrophenyl)piperidin-4-one
761440-64-6

1-(3-methoxy-4 nitrophenyl)piperidin-4-one

dimethyl amine
124-40-3

dimethyl amine

1-(3-methoxy-4-nitrophenyl)-N,N-dimethylpiperidine-4-amine
1089279-90-2

1-(3-methoxy-4-nitrophenyl)-N,N-dimethylpiperidine-4-amine

Conditions
Conditions Yield
1-(3-methoxy-4 nitrophenyl)piperidin-4-one; dimethyl amine; With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; 1,2-dichloro-ethane;
With sodium hydrogencarbonate; In water; pH=> 7;
88%
With formic acid; trimethyl orthoformate; In tetrahydrofuran; at 70 ℃; for 7h;
75.04%
1-(3-methoxy-4 nitrophenyl)piperidin-4-one
761440-64-6

1-(3-methoxy-4 nitrophenyl)piperidin-4-one

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine
1089279-61-7

4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine

Conditions
Conditions Yield
1-(3-methoxy-4 nitrophenyl)piperidin-4-one; 1-t-Butoxycarbonylpiperazine; With acetic acid; triethylamine; In toluene; at 20 ℃; for 0.5h;
With sodium tris(acetoxy)borohydride; In toluene; for 4h;
With sodium hydroxide; sodium hydrogencarbonate; trifluoroacetic acid; more than 3 stages;
81%
1-(3-methoxy-4 nitrophenyl)piperidin-4-one; 1-t-Butoxycarbonylpiperazine; With acetic acid; triethylamine; In toluene; at 20 ℃; for 0.5h; Inert atmosphere;
With sodium tetrahydroborate; In toluene; at 20 ℃; for 4h;
With sodium hydrogencarbonate; In toluene; for 48h;
81%

Global suppliers and manufacturers

Global( 9) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • ENAO Chemical Co, Limited
  • Business Type:Lab/Research institutions
  • Contact Tel:86--15307605669
  • Emails:sales@enaochem.com
  • Main Products:1
  • Country:China (Mainland)
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