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Cas Database

762-04-9

762-04-9

Identification

  • Product Name:Diethyl phosphite

  • CAS Number: 762-04-9

  • EINECS:212-091-6

  • Molecular Weight:138.103

  • Molecular Formula: C4H11O3P

  • HS Code:29209014

  • Mol File:762-04-9.mol

Synonyms:Ethylphosphite, (EtO)2(HO)P (6CI);Diethoxyphosphine oxide;Diethyl acid phosphite;Diethyl hydrogen phosphite;Phosphonic acid,diethyl ester;Diethyl phosphonate;Hydrogendiethyl phosphite;NSC 2665;Diethyl phosphonate;Ethyl phosphonate;phosphonic acid, diethyl ester;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Danger

  • Hazard Statement:H317 May cause an allergic skin reactionH318 Causes serious eye damage

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. (ERG, 2016) /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

  • Fire-fighting measures: Suitable extinguishing media Use water spray to cool unopened containers. Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. Substance may be transported hot. For hybrid vehicles, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. If molten aluminum is involved, refer to ERG Guide 169. (ERG, 2016) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Moisture sensitive.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Diethyl phosphite
  • Packaging:50 g
  • Price:$ 15
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Diethyl phosphite
  • Packaging:10 g
  • Price:$ 10
  • Delivery:In stock
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  • Manufacture/Brand:Strem Chemicals
  • Product Description:Diethylphosphite, min. 95%
  • Packaging:500g
  • Price:$ 127
  • Delivery:In stock
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  • Manufacture/Brand:Strem Chemicals
  • Product Description:Diethylphosphite, min. 95%
  • Packaging:100g
  • Price:$ 42
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Diethyl phosphite technical grade, 94%
  • Packaging:1l
  • Price:$ 107
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Diethyl phosphite 98%
  • Packaging:250g
  • Price:$ 59.6
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  • Manufacture/Brand:Oakwood
  • Product Description:Diethyl phosphite
  • Packaging:25g
  • Price:$ 15
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  • Manufacture/Brand:Oakwood
  • Product Description:Diethyl phosphite
  • Packaging:5g
  • Price:$ 10
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  • Manufacture/Brand:Oakwood
  • Product Description:Diethyl phosphite
  • Packaging:100g
  • Price:$ 36
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  • Manufacture/Brand:BroadPharm
  • Product Description:Diethyl phosphite 97%
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Relevant articles and documentsAll total 157 Articles be found

-

Mitsunobu,O.,Mukaiyama,T.

, p. 3005 - 3006 (1964)

-

-

Silver,Luz

, p. 1091,1092 (1962)

-

-

Terauchi et al.

, p. 5073 (1969)

-

Reaction of N-(benzyloxycarbonyl)aminobenzylphosphonous acid with ethyl orthoformate

Stano, Adrian,Mucha, Artur,Kafarski, Pawel

, p. 4269 - 4277 (1999)

Reaction of N-(benzyloxycarbonyl)aminobenzylphosphonous acid with ethyl orthoformate afforded two major products diethyl N(benzyloxycarbonyl)aminobenzylphosphinite and ethyl (diethoxymethyl)[N- (benzyloxy-carbonyl)aminobenzyl]phosphinate, a product of addition of phosphonous acid to orthoformate.

Synthesis of Pyridiniumboranephosphonate Diesters and Related Compounds using Trityl Cation as a Borane Hydride Acceptor

Rachwalak, Marta,Go??biewska, Justyna,Jakubowski, Tomasz,Stawinski, Jacek

, p. 509 - 517 (2021)

Boranephosphonate diesters react with pyridine and some tertiary amines in the presence of dimethoxytrityl chloride used as a borane hydride acceptor, to afford the boron-modified phosphodiester analogues containing a P-B-N structural motif. The reaction provides a convenient entry to pyridinium- and ammoniumboranephosphonates derived from the corresponding alkyl, aryl, or nucleoside boranephosphonate diesters. Some aspects of the synthetic protocol, mechanistic features related to a possible intermediate involved, and the role of the solvents used, are discussed.

Access to α-aminophosphonic acid derivatives and phosphonopeptides by [Rh(P-OP)]-catalyzed stereoselective hydrogenation

Fernández-Pérez, Héctor,Lenartowicz, Pawe?,Carreras, Lucas,Grabulosa, Arnald,Kafarski, Pawe?,Vidal-Ferran, Anton

, p. 14779 - 14784 (2020)

The hydrogenation of N-substituted vinylphosphonates using rhodium complexes derived from P-OP ligands L1, ent-L1, or (R,R)-Me-DuPHOS as catalysts has been successfully accomplished, achieving very high levels of stereoselectivity (up to 99% ee or de). Th

Electrochemical synthesis of phosphorus esters from white phosphorus in the presence of copper complexes and ethanol

Budnikom,Kafiyatullina,Sinyashin,Abdreimova

, p. 929 - 938 (2003)

In the presence of white phosphorus the redox potentials of the copper ions change and the potential of the reduction wave of CuI/Cu 0 shifts noticeably toward more positive values. The Cu I-P4 complex is characterized by a lower value of the electrochemical gap, that is, higher polarizability and reactivity compared to those of the free CuI cation. Phosphorus esters can be synthesized from P4 and ethanol. The latter is in the composition of the copper(II) complexes, which act as a catalyst-charge mediator.

Reaction of diethyl butane-1-phosphonate with the surface of tin dioxide

Ikaev,Polezhaeva,Mingalev,Lisichkin

, p. 417 - 420 (2008)

Reaction of diethyl butane-1-phosphonate with the surface of tin dioxide was studied. The reaction involves grafting of the phosphonate residue onto the oxide surface; in the process, one or both ethoxy groups are eliminated. The resulting grafted layer exhibits fairly high resistance to hydrolysis and heat.

Preparation method of important chemical raw material

-

Paragraph 0036-0051, (2021/06/06)

The invention provides a preparation method of diethyl phosphite, which is characterized by comprising the following steps: at room temperature, adding phosphorous acid, a silver catalyst and water into a reaction container with stirring until the reactants are dissolved; then slowly dropwise adding ethanol into the reaction container, simultaneously heating the system to 50-100 DEG C, reacting for 1-4 hours, stopping stirring after the reaction is finished, standing the system; collecting an organic layer, and performing reduced pressure distillation to obtain a product. As the soluble silver salt is adopted as the catalyst, the reaction can be quickly and efficiently catalyzed in water, compared with the prior art, the reaction condition is milder, the water is adopted as the solvent to be more environment-friendly, and as water is generated in the reaction and is consistent with the reaction solvent, the content of water is increased after the reaction; therefore, the method provided by the invention is more beneficial to the rapid separation of water-insoluble diethyl phosphite from the system, so that the post-treatment is simpler and more efficient, the reaction time is saved, and the yield and purity of the product are improved.

Photochemical Radical C–H Halogenation of Benzyl N-Methyliminodiacetyl (MIDA) Boronates: Synthesis of α-Functionalized Alkyl Boronates

Yang, Ling,Tan, Dong-Hang,Fan, Wen-Xin,Liu, Xu-Ge,Wu, Jia-Qiang,Huang, Zhi-Shu,Li, Qingjiang,Wang, Honggen

supporting information, p. 3454 - 3458 (2020/12/17)

α-Haloboronates are useful organic synthons that can be converted to a diverse array of α-substituted alkyl borons. Methods to α-haloboronates are limiting and often suffer from harsh reaction conditions. Reported herein is a photochemical radical C-H halogenation of benzyl N-methyliminodiacetyl (MIDA) boronates. Fluorination, chlorination, and bromination reactions were effective by using this protocol. Upon reaction with different nucleophiles, the C?Br bond in the brominated product could be readily transformed to a series of C?C, C?O, C?N, C?S, C?P, and C?I bonds, some of which are difficult to forge with α-halo sp2-B boronate esters. An activation effect of B(MIDA) moiety was found.

A greener protocol for the synthesis of phosphorochalcogenoates: Antioxidant and free radical scavenging activities

Mailahn, Daniela H.,Iarocz, Lucas E.B.,Nobre, Patrick C.,Perin, Gelson,Sinott, Airton,Pesarico, Ana Paula,Birmann, Paloma T.,Savegnago, Lucielli,Silva, Márcio S.

, (2020/12/07)

In this contribution, a metal- and base-free protocol has been developed for the synthesis of phosphorochalcogenoates (Se and Te) by using DMSO as solvent at 50 °C. A variety of phosphorochalcogenoates were prepared from diorganyl dichalcogenides and H-phosphonates, leading to the formation of a Chal-P(O) bond, in a rapid procedure with good to excellent yields. A full structural elucidation of products was accessed by 1D and 2D NMR, IR, CGMS, and HRMS analyses, and a stability evaluation of the phosphorochalcogenoates was performed for an effective operational description of this simple and feasible method. Typical 77Se{1H} (δSe = 866.0 ppm), 125Te{1H} (δTe = 422.0 ppm) and 31P{1H} (δP = ?1.0, ?13.0 and ?15.0 ppm) NMR chemical shifts were imperative to confirm the byproducts, in which this stability study was also important to select some products for pharmacological screening. The phosphorochalcogenoates were screened in vitro and ex vivo tests for the antioxidant potential and free radical scavenging activity, as well as to investigation toxicity in mice through of the plasma levels of markers of renal and hepatic damage. The pharmacological screening of phosphorochalcogenoates indicated that compounds have antioxidant propriety in different assays and not changes plasma levels of markers of renal and hepatic damage, with excision of 3g compound that increased plasma creatinine levels and decreased plasma urea levels when compared to control group in the blood mice. Thus, these compounds can be promising synthetic antioxidants that provide protection against oxidative diseases.

Reaction of sodium N-benzylideneglycinate with dialkyl chlorophosphites in the presence of water

Dimukhametov, Mudaris N.,Mironov, Vladimir F.,Islamov, Daut R.,Litvinov, Igor A.,Gnezdilov, Oleg I.,Danilova, Yuliya V.

, p. 107 - 109 (2021/02/16)

The outcome of reaction of sodium N-benzylideneglycinate containing water in its crystal lattice with dialkyl chlorophosphites depends on the mode of addition of the latter. Upon the simultaneous mixing of the reactants, 1,4-bis[α-(dialkoxyphosphoryl)benz

Process route upstream and downstream products

Process route

Conditions
Conditions Yield
With dihydrogen peroxide; In water;
Chlorpyrifos
2921-88-2,39475-55-3

Chlorpyrifos

3,5,6-trichloropyridin-2 ol
6515-38-4

3,5,6-trichloropyridin-2 ol

chlopyrifos oxon
5598-15-2

chlopyrifos oxon

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

Conditions
Conditions Yield
With titanium(IV) dioxide; In water; acetonitrile; at 25 ℃; for 0.5h; Concentration; Irradiation;
ethanol
64-17-5

ethanol

triethyl phosphite
122-52-1

triethyl phosphite

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

Ethylphosphorige Saeure
15845-66-6

Ethylphosphorige Saeure

Conditions
Conditions Yield
ethanol; With phosphorus(III) oxide; at 40 ℃; for 0.333333h;
triethyl phosphite; at 84 - 100 ℃; for 4h; Product distribution / selectivity;
91.6 %Spectr.
8.4 %Spectr.
phosphonic Acid
13598-36-2

phosphonic Acid

ethanol
64-17-5

ethanol

water
7732-18-5

water

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

Ethylphosphorige Saeure
15845-66-6

Ethylphosphorige Saeure

Conditions
Conditions Yield
In ethanol; heating H3PO3 with anhydrous ethanol in a sealed tube at 100 °C for 2 days; equilibrium;; Kinetics;
In ethanol; heating H3PO3 with anhydrous ethanol in a sealed tube at 100 °C for 2 days; equilibrium;; Kinetics;
sodium diethyl phosphite
2303-76-6,118080-94-7

sodium diethyl phosphite

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

diphosphorous acid tetraethyl ester
21646-99-1

diphosphorous acid tetraethyl ester

hypophosphoric acid tetraethyl ester
679-37-8

hypophosphoric acid tetraethyl ester

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

Ethylphosphorige Saeure
15845-66-6

Ethylphosphorige Saeure

Conditions
Conditions Yield
In tetrahydrofuran;
benzyl bromide
100-39-0

benzyl bromide

triethyl phosphite
122-52-1

triethyl phosphite

O,O-diethyl benzylphosphonate
1080-32-6

O,O-diethyl benzylphosphonate

benzylphosphonic acid monoethyl ester
18933-98-7

benzylphosphonic acid monoethyl ester

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

Ethylphosphorige Saeure
15845-66-6

Ethylphosphorige Saeure

Conditions
Conditions Yield
With 1-butyl-3-methylimidazolium trifluoromethanesulfonimide; at 110 ℃; for 0.333333h; Further Variations:; Temperatures; Solvents; Reagents; Product distribution;
coumaphos
56-72-4

coumaphos

Coralox
321-54-0

Coralox

3-chloro-4-methylumbelliferone
6174-86-3

3-chloro-4-methylumbelliferone

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

Conditions
Conditions Yield
With water; dihydrogen peroxide; In ethanol; at 40 ℃; Temperature; Reagent/catalyst; Kinetics;
diethyl benzoylphosphonate
3277-27-8

diethyl benzoylphosphonate

N-butylamine
109-73-9,85404-21-3

N-butylamine

diethyl 1-(diethylphosphoryloxy)-1-phenylmethylphosphonate
18104-91-1

diethyl 1-(diethylphosphoryloxy)-1-phenylmethylphosphonate

N-butylbenzamide
2782-40-3

N-butylbenzamide

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

Conditions
Conditions Yield
In diethyl ether; for 0.333333h; Ambient temperature;
42%
18%
79%
sodium diethyl phosphite
2303-76-6,118080-94-7

sodium diethyl phosphite

Diethyl 2-bromomalonate
685-87-0

Diethyl 2-bromomalonate

1,1,2,2-tetracarboethoxy-ethylene
6174-95-4

1,1,2,2-tetracarboethoxy-ethylene

Conditions
Conditions Yield
In benzene;
In benzene;
diethyl (tert-butyl) phosphite
14540-22-8

diethyl (tert-butyl) phosphite

acetyl chloride
75-36-5

acetyl chloride

tertiary butyl chloride
507-20-0

tertiary butyl chloride

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

diethyl acetylphosphonate
919-19-7

diethyl acetylphosphonate

Conditions
Conditions Yield
With triethylamine hydrochloride; In chloroform; Product distribution; relative yields of products with respect to the concentrations and proportions of the reactants and absence or presence of Et3N*HCl;

Global suppliers and manufacturers

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  • COLORCOM LTD.
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  • Chemwill Asia Co., Ltd.
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  • Shanghai Upbio Tech Co.,Ltd
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  • Main Products:88
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  • Wuhan PharmChem Co.,Ltd
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  • Contact Tel:027-84452116
  • Emails:steven@cspharmchem.com
  • Main Products:32
  • Country:China (Mainland)
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