762-04-9Relevant articles and documents
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Mitsunobu,O.,Mukaiyama,T.
, p. 3005 - 3006 (1964)
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Terauchi et al.
, p. 5073 (1969)
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Synthesis of Pyridiniumboranephosphonate Diesters and Related Compounds using Trityl Cation as a Borane Hydride Acceptor
Rachwalak, Marta,Go??biewska, Justyna,Jakubowski, Tomasz,Stawinski, Jacek
, p. 509 - 517 (2021)
Boranephosphonate diesters react with pyridine and some tertiary amines in the presence of dimethoxytrityl chloride used as a borane hydride acceptor, to afford the boron-modified phosphodiester analogues containing a P-B-N structural motif. The reaction provides a convenient entry to pyridinium- and ammoniumboranephosphonates derived from the corresponding alkyl, aryl, or nucleoside boranephosphonate diesters. Some aspects of the synthetic protocol, mechanistic features related to a possible intermediate involved, and the role of the solvents used, are discussed.
Electrochemical synthesis of phosphorus esters from white phosphorus in the presence of copper complexes and ethanol
Budnikom,Kafiyatullina,Sinyashin,Abdreimova
, p. 929 - 938 (2003)
In the presence of white phosphorus the redox potentials of the copper ions change and the potential of the reduction wave of CuI/Cu 0 shifts noticeably toward more positive values. The Cu I-P4 complex is characterized by a lower value of the electrochemical gap, that is, higher polarizability and reactivity compared to those of the free CuI cation. Phosphorus esters can be synthesized from P4 and ethanol. The latter is in the composition of the copper(II) complexes, which act as a catalyst-charge mediator.
Preparation method of important chemical raw material
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Paragraph 0036-0051, (2021/06/06)
The invention provides a preparation method of diethyl phosphite, which is characterized by comprising the following steps: at room temperature, adding phosphorous acid, a silver catalyst and water into a reaction container with stirring until the reactants are dissolved; then slowly dropwise adding ethanol into the reaction container, simultaneously heating the system to 50-100 DEG C, reacting for 1-4 hours, stopping stirring after the reaction is finished, standing the system; collecting an organic layer, and performing reduced pressure distillation to obtain a product. As the soluble silver salt is adopted as the catalyst, the reaction can be quickly and efficiently catalyzed in water, compared with the prior art, the reaction condition is milder, the water is adopted as the solvent to be more environment-friendly, and as water is generated in the reaction and is consistent with the reaction solvent, the content of water is increased after the reaction; therefore, the method provided by the invention is more beneficial to the rapid separation of water-insoluble diethyl phosphite from the system, so that the post-treatment is simpler and more efficient, the reaction time is saved, and the yield and purity of the product are improved.
A greener protocol for the synthesis of phosphorochalcogenoates: Antioxidant and free radical scavenging activities
Mailahn, Daniela H.,Iarocz, Lucas E.B.,Nobre, Patrick C.,Perin, Gelson,Sinott, Airton,Pesarico, Ana Paula,Birmann, Paloma T.,Savegnago, Lucielli,Silva, Márcio S.
, (2020/12/07)
In this contribution, a metal- and base-free protocol has been developed for the synthesis of phosphorochalcogenoates (Se and Te) by using DMSO as solvent at 50 °C. A variety of phosphorochalcogenoates were prepared from diorganyl dichalcogenides and H-phosphonates, leading to the formation of a Chal-P(O) bond, in a rapid procedure with good to excellent yields. A full structural elucidation of products was accessed by 1D and 2D NMR, IR, CGMS, and HRMS analyses, and a stability evaluation of the phosphorochalcogenoates was performed for an effective operational description of this simple and feasible method. Typical 77Se{1H} (δSe = 866.0 ppm), 125Te{1H} (δTe = 422.0 ppm) and 31P{1H} (δP = ?1.0, ?13.0 and ?15.0 ppm) NMR chemical shifts were imperative to confirm the byproducts, in which this stability study was also important to select some products for pharmacological screening. The phosphorochalcogenoates were screened in vitro and ex vivo tests for the antioxidant potential and free radical scavenging activity, as well as to investigation toxicity in mice through of the plasma levels of markers of renal and hepatic damage. The pharmacological screening of phosphorochalcogenoates indicated that compounds have antioxidant propriety in different assays and not changes plasma levels of markers of renal and hepatic damage, with excision of 3g compound that increased plasma creatinine levels and decreased plasma urea levels when compared to control group in the blood mice. Thus, these compounds can be promising synthetic antioxidants that provide protection against oxidative diseases.