762-49-2Relevant articles and documents
Edge,Kochi
, p. 6485,6491-6493 (1972)
Conformational stability, far-infrared spectra, barriers to internal rotation, vibrational assignment and RHF/STO-3G* calculations of 1-bromo-2-fluoroethane
Durig, J. R.,Liu, Jian,Little, T. S.
, p. 25 - 48 (1991)
The far-IR spectrum (350-35 cm-1) of gaseous 1-bromo-2-fluoroethane, BrCH2CH2F, has been recorded at a resolution of 0.10 cm-1.The fundamental asymmetric torsional frequencies of the more stable trans (two halogen atoms oriented trans) and high energy gauche conformers have been observed at 125.3 cm-1 and 111.3 cm-1, respectively, and the asymmetric torsional potential function governing internal rotation about the C-C bond has been determined.This potential function gives values for the torsional potential coefficients of V1= 584+/-6, V2=-147+/-4, V3=1217+/-11, V4=138+/-2, and V6=-21+/-4 cm-1, and a dihedral angle (FCCBr) of 67 deg for the gauche conformer.The trans to gauche, gauche to gauche, and gauche to trans barriers have been determined to be 1356 cm-1, 1418 cm-1 and 973 cm-1, rspectively, with an energy difference between the conformations of 383+/-21 cm-1 (1.09+/-0.06 kcal mol-1).From studies of the Raman spectra at variable temperatures the conformational energy difference has been determined to be 350+/-87 cm-1 (1.00+/-0.25 kcal mol-1) with the trans more stable and 300+/-46 cm-1 (0.86+/-0.13 kcal mol-1) with the gauche more stable for the gas and liquid, respectively.A complete assignment of the vibrational spectra including the IR (3500-400 cm-1) spectra of the gas and solid and the Raman (3200-10 cm-1) spectra of the gas, liquid and solid is proposed.The structural parameters, conformational stabilities, barriers to internal rotation and fundamental vibrational frequencies which have been determined from experiment, are compared to those obtained from ab initio Hartree-Fock gradient calculations and to the corresponding quantities obtained for some similar molecules.
COMPOUNDS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF ALZHEIMER'S DISEASE AND RELATED DISORDERS
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Page/Page column 61, (2009/10/22)
One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyIoidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.
A Rapid and Efficient Method for the Fluoroalkylation of Amines and Amides. Development of a Method Suitable for Incorporation of the Short-Lived Positron Emitting Radionuclide Fluorine-18
Chi, Dae Yoon,Kilbourn, Michael R.,Katzenellenbogen, John A.,Welch, Michael J.
, p. 658 - 664 (2007/10/02)
We have described a two-step method for the preparation of fluoroalkyl-substituted amines and amides.The sequence involves fluoride ion displacement of a haloalkyl trifluoromethanesulfonate (triflate), followed by fluoroalkylation of the heteroatom system (amine or amide) by the fluoroalkyl halide.Alternatively, the fluoroalkyl halide can be prepared by halofluorination of a terminal olefin.These reactions have been used to prepare various fluoroalkyl derivatives of N-phenylpiperazine and N-fluoroalkyl derivatives of the neuroleptic agent spiperone (7).The sequence is rapid, convenient, and efficient, even when fluoride ion is the limiting reagent.Therefore, it is readily adaptable to the preparation of a variety of compounds labeled with the short half-life (t1/2 = 110 min) positron-emitting radionuclide fluorine-18.
