7633-32-1

Basic information

• Product Name: ACETICACID,2-OXO-,1,1-DIMETHYLETHYLESTER
• Synonyms: ACETICACID,2-OXO-,1,1-DIMETHYLETHYLESTER
• CAS NO: 7633-32-1
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.1418
• EINECS: -0
• Mol File: 7633-32-1.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 34 °C(Press: 11 Torr)
• Appearance: /
• Density: 1.013±0.06 g/cm3(Predicted)
• CAS DataBase Reference: ACETICACID,2-OXO-,1,1-DIMETHYLETHYLESTER(CAS DataBase Reference)
• NIST Chemistry Reference: ACETICACID,2-OXO-,1,1-DIMETHYLETHYLESTER(7633-32-1)
• EPA Substance Registry System: ACETICACID,2-OXO-,1,1-DIMETHYLETHYLESTER(7633-32-1)

Safety Data

• Hazardous Substances Data: 7633-32-1(Hazardous Substances Data)

Usage

General Description

Aceticacid,2-oxo-,1,1-Dimethylethylester, also known as Acetoacetic Acid tert-butyl ester, is an organic chemical compound with the formula CH3COCCH2OC(CH3)3. This clear to pale yellow liquid has a strong, fruity odor and is not soluble in water. Acetoacetic Acid tert-butyl ester is commonly used in the production of pharmaceuticals, pesticides, and other chemicals. It can irritate the eyes, skin, and respiratory tract upon exposure. As such, safety measures should be in place when handling this chemical.

Upstream product

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Downstream Products

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• 114463-00-2 t-butyl α-hydroxy-α-(2-oxo-4-vinylazetidin-1-yl)acetate 
• 78840-75-2 t-butyl α-chloro-α-(2-oxo-4-vinylazetidin-1-yl)acetate 
• 68485-87-0 2-Hydroxy-2-<2-oxo-4-(2-propenyl)-1-azetidinyl>essigsaeure-tert-butylester 
• 68485-91-6 Hydroxy-[2-oxo-4-(2-oxo-propyl)-azetidin-1-yl]-acetic acid tert-butyl ester 

Relevant articles and documents

COMPOSITIONS AND METHODS RELATED TO MOLECULAR CONJUGATION

The invention relates to activated Michael acceptor (AMA) compounds that can undergo conjugation with biomolecules containing Michael donor moieties, thereby providing plasma-stable antibody-drug conjugates (ADCs). Pharmaceutical compositions of the ADCs are disclosed as well. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.

A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling

The direct union of primary, secondary, and tertiary carboxylic acids with a chiral glyoxylate-derived sulfinimine provides rapid access into a variety of enantiomerically pure α-amino acids (>85 examples). Characterized by operational simplicity, this radical-based reaction enables the modular assembly of exotic α-amino acids, including both unprecedented structures and those of established industrial value. The described method performs well in high-throughput library synthesis, and has already been implemented in three distinct medicinal chemistry campaigns.

A Short Synthesis of the Mould Metabolite (R)-(+)-Carolinic Acid from (S)-Lactic Acid

(R)-(+)-Carolinic acid was prepared in seven steps and 59% yield from inexpensive benzyl l-lactate, the configuration of which was inverted by a Mitsunobu reaction with trifluoroacetate. The resulting benzyl d-lactate was cyclised by a domino addition-Wittig alkenation reaction with Ph3PCCO. The product tetronic acid was acylated with a second equivalent of this ylide to give a 3-acylylidenetetronic acid, which was olefinated directly with tert-butyl glyoxylate. The product alkene was hydrogenated and deprotected to afford pure crystalline (R)-(+)-carolinic acid, which proved inactive against Staphylococcus aureus and Escherichia coli mutant D21f2.