7640-33-7

Basic information

• Product Name: 7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE
• Synonyms: 5-Chlor-7-brom-8-hydroxychinolin;7-bromo-5-chloro-8-quinolino;8-Quinolinol, 7-bromo-5-chloro-;5-CHLORO-7-BROMO-8-HYDROXYQUINOLINE;7-BROMO-5-CHLORO-8-CHINOLINOL;7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE;7-BROMO-5-CHLORO-8-QUINOLINOL;7-bromo-5-chloroquinolin-8-ol
• CAS NO: 7640-33-7
• Molecular Formula: C₉H₅BrClNO
• Molecular Weight: 258.5
• EINECS: 231-574-2
• Product Categories: Haloquinolines;Hydroxyquinolines;Quinolines
• Mol File: 7640-33-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 181°C
• Boiling Point: 358.4ºC at 760 mmHg
• Flash Point: 170.6ºC
• Appearance: /
• Density: 1.803g/cm3
• Vapor Pressure: 1.23E-05mmHg at 25°C
• Refractive Index: 1.72
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE(7640-33-7)
• EPA Substance Registry System: 7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE(7640-33-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-26-36/37/39-25
• RTECS: VC4585000
• Hazardous Substances Data: 7640-33-7(Hazardous Substances Data)

Usage

General Description

7-Bromo-5-chloro-8-hydroxyquinoline is an organobromine compound which also contains chlorine. It is a derived multi-substituted quinoline made up of a benzene ring fused to a pyridine ring, where the benzene ring contains a bromo and a hydroxy substituent at the 7th and 8th position, while the pyridine ring contains a chloro substituent at the 5th position. This chemical, owing to its structure, has potential medicinal properties and can be used for the synthesis of complex pharmaceuticals. It can act as a versatile intermediate in the synthesis of various pharmaceutical agents due to the active functional groups present in its structure. It does not have significant industrial uses, mostly used in academic and pharmaceutical research.

InChI:InChI=1/C9H5BrClNO/c10-6-4-7(11)5-2-1-3-12-8(5)9(6)13/h1-4,13H

Upstream product

• 148-24-3 8-quinolinol 
• 95-85-2 2-hydroxy-5-chloro-aniline 
• 521-74-4 broxyquinoline 
• 130-16-5 5-Chloro-8-hydroxyquinoline 

Downstream Products

• 457931-02-1 C₁₀H₇BrClNO 

Relevant articles and documents

Study on Relationship Between Fluorescence Properties and Structure of Substituted 8-Hydroxyquinoline Zinc Complexes

Organic light-emitting diodes (OLEDs) produced from 8-hydroxyquinoline metal complexes play a vital role in modern electroluminescent devices. In this manuscript, a series of 8-hydroxyquinoline derivatives were synthesized by different methods and their corresponding zinc metal complexes were prepared. The UV and fluorescence properties of the complexes were measured aiming to understand the effect of substituents at the quinoline ring on the fluorescence properties of the complexes. When the C-5 of 8-hydroxyquinoline was replaced by halogen group, the fluorescence emission wavelengths had been red-shifted, at the same time, blue-shifted of fluorescence emission wavelength was observed when the C-5 position of 8-hydroxyquinoline was substituted by electron-withdrawing group. When the C-4 position of 8-hydroxyquinolie was substituted by methyl or the C-5 position was substituted by sulfonic acid group, the corresponding zinc complexes had higher fluorescence intensity than 8-hydroxyquinolie zinc.