766-66-5Relevant articles and documents
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Smith,N.P.,Stevens,D.R.
, p. 1298 - 1308 (1979)
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Infrared and theoretical calculations in 2-halocycloheptanones conformational analysis
Rozada, Thiago C.,Gauze, Gisele F.,Favaro, Denize C.,Rittner, Roberto,Basso, Ernani A.
experimental part, p. 277 - 287 (2012/07/14)
2-Halocycloheptanones (Halo = F, Cl, Br and I) were synthesized and their conformational analysis was performed through infrared spectroscopy data. The corresponding conformers geometries and energies were obtained by theoretical calculations at B3LYP/aug-cc-pVDZ level of theory in the isolated state and in solution. It was observed, by both approaches, that the conformational preferences were very sensitive to the solvent polarity, since its increase led to an increase in the population of the more polar conformer. An analysis of these conformational equilibria showed they suffer also the influence of stereoelectronic effects, like hyperconjugation and steric effects. These results were interpreted using natural bond orbital (NBO) analysis, which indicated that the electronic delocalization to the orbital π* CO is directly involved in the stability increase of conformers I and II. The relative effect of the period of the halogen can also be noted, with changes in the conformational preferences and in the energies involved in the interactions of NBO.
A safe, convenient and efficient one-pot synthesis of α-chloroketone acetals directly from ketones using iodobenzene dichloride
Yu, Jun,Zhang, Chi
body text, p. 2324 - 2328 (2010/01/13)
Various ketones, including aliphatic and aromatic ketones, can be directly converted into their corresponding α-chloroketone acetals in high to excellent yields using iodobenzene dichloride in ethylene glycol in the presence of 4 A molecular sieves at room temperature. Georg Thieme Verlag Stuttgart.