76742-17-1 Usage
General Description
"Cytidine, 5'-(hydrogen 4-morpholinylphosphonate)" or "CyMP" is a phosphate prodrug of cytidine with antiviral properties and more. It's designed to be more cell-permeable than unmodified cytidine, which is a fundamental building block of our genetic code. Also, cytidine is involved in a variety of important processes in the body, including energy metabolism, nucleic acid synthesis, and neurotransmission. The 4-morpholinylphosphonate modification, on the other hand, is believed to help with delivery of the cytidine to the needed sites in the body, and may confer resistance to enzymatic degradation. Thus this chemical compound could potentially help with therapeutic interventions in a variety of medical scenarios.
Check Digit Verification of cas no
The CAS Registry Mumber 76742-17-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,7,4 and 2 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 76742-17:
(7*7)+(6*6)+(5*7)+(4*4)+(3*2)+(2*1)+(1*7)=151
151 % 10 = 1
So 76742-17-1 is a valid CAS Registry Number.
76742-17-1Relevant articles and documents
Improved synthesis of cytidine diphosphate choline (CDP-choline) via selective phosphorylation
Xia, Ran,Sun, Li-Ping,Chen, Lei-Shan
, p. 358 - 360 (2016/07/06)
An improved, three-step synthesis of cytidine diphosphate choline (CDP-choline) from cytidine was achieved in 68% overall yield. Selective phosphorylation of cytidine was accomplished by the use of morpholinophosphodichloridate to give cytidine-5′-phosphomorpholide, which was condensed with choline phosphate chloride in the presence of a catalytic amount of H2SO4 to give CDP-choline. The intermediates and products could be efficiently purified by recrystallisation, thus avoiding the use of chromatography at all stages. The reaction could be scaled up to 200 g in 64% overall yield, making this route attractive for industrial application.
SIMPLE SYNTHESIS OF CYTIDINE DIPHOSPHATE CHOLINE
Varlamova, T. V.,Kolodkina, I. I.,Yurkevich, A. M.
, p. 932 - 935 (2007/10/02)
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