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768-60-5

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768-60-5 Usage

Chemical Properties

Pale Yellow Oil

Uses

Different sources of media describe the Uses of 768-60-5 differently. You can refer to the following data:
1. Intermediate in the synthesis of histamine H3-receptor antagonists. Also utilized to prepare its luminescent copper complex
2. Intermediates of Liquid Crystals
3. 1,3-dipolar cycloaddition of acceptor-cyclopropylmethylsilanes affords functionalized cyclopentenes in good yields.1
4. 4-Ethynylanisole was used in the synthesis of photo luminescent 1,2-dihydrophosphinines via a [4 + 2] cycloaddition. Along with an arylboronic acid and sodium azide in a copper-catalyzed, three-component synthesis of trisubstituted 1,2,4-triazoles. In a study of a gold (III)-catalyzed hydroamination of alkynes leading to N-vinylindoles3.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 9, p. 230, 1998Synthesis, p. 305, 1978Tetrahedron, 62, p. 6673, 2006 DOI: 10.1016/j.tet.2005.12.077

General Description

4-Ethynylanisole forms the corresponding propargyl aldehyde in good yield directly from DMF-dimethyl acetal without the need for making an acetylide salt. 1,3-dipolar cycloaddition of acceptor-cyclopropylmethylsilanes affords functionalized cyclopentenes in good yields.

Check Digit Verification of cas no

The CAS Registry Mumber 768-60-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,6 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 768-60:
(5*7)+(4*6)+(3*8)+(2*6)+(1*0)=95
95 % 10 = 5
So 768-60-5 is a valid CAS Registry Number.

768-60-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H26283)  4-Methoxyphenylacetylene, 99%   

  • 768-60-5

  • 1g

  • 320.0CNY

  • Detail
  • Alfa Aesar

  • (H26283)  4-Methoxyphenylacetylene, 99%   

  • 768-60-5

  • 5g

  • 639.0CNY

  • Detail
  • Aldrich

  • (206490)  4-Ethynylanisole  97%

  • 768-60-5

  • 206490-1G

  • 747.63CNY

  • Detail
  • Aldrich

  • (206490)  4-Ethynylanisole  97%

  • 768-60-5

  • 206490-5G

  • 2,365.74CNY

  • Detail

768-60-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Ethynylanisole

1.2 Other means of identification

Product number -
Other names 1-ethynyl-4-methoxybenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:768-60-5 SDS

768-60-5Relevant articles and documents

Preparation and properties of high birefringence phenylacetylene isothiocyanato-based blend liquid crystals

He, Zemin,Wang, Haiyang,Zhang, Huimin,Zhang, Yongming,Zhao, Yang,Zhao, Yuzhen

, (2022/04/03)

A series of compounds of with high birefringence containing alkoxy–phenylacetylene–isothiocyanato structure were synthesized and characterized. The chemical structures of these compounds were confirmed by FT-IR and 1H-NMR, and transition temperatures and birefringence were measured. One of these compounds with good liquid crystal property and high birefringence was mixed with host liquid crystal to form blend liquid crystal. The effects of the concentration of the compound on phase temperature range, birefringence, resistivity, dielectric anisotropy and photoelectric properties were discussed. The results showed that blend liquid crystal (with 7 wt% compound) exhibited excellent comprehensive performance.

Acetylenic Replacement of Albicidin's Methacrylamide Residue Circumvents Detrimental E/Z Photoisomerization and Preserves Antibacterial Activity

Behroz, Iraj,Kleebauer, Leonardo,Hommernick, Kay,Seidel, Maria,Gr?tz, Stefan,Mainz, Andi,Weston, John B.,Süssmuth, Roderich D.

, p. 9077 - 9086 (2021/05/27)

The natural product albicidin is a highly potent inhibitor of bacterial DNA gyrase. Its outstanding activity, particularly against Gram-negative pathogens, qualifies it as a promising lead structure in the search for new antibacterial drugs. However, as we show here, the N-terminal cinnamoyl moiety of albicidin is susceptible to photochemical E/Z isomerization. Moreover, the newly formed Z isomer exhibits significantly reduced antibacterial activity, which hampers the development and biological evaluation of albicidin and potent derivatives thereof. Hence, we synthesized 13 different variants of albicidin in which the vulnerable para-coumaric acid moiety was replaced; this yielded photostable analogues. Biological activity assays revealed that diaryl alkyne analogues exhibited virtually undiminished antibacterial efficacy. This promising scaffold will therefore serve as a blueprint for the design of a potent albicidin-based drug.

Cu-mediated or metal-free alkylation of gem-dibromoalkenes with tertiary, secondary and primary alkyl Grignard reagents

Deng, Yupian,Zhang, Xuxue,Liu, Chuan,Cao, Song

, (2021/01/18)

A novel copper-mediated or transition-metal-free alkylation of gem-dibromoalkenes with tertiary, secondary and primary alkyl Grignard reagents was described. The outcomes of these reactions were found to be highly dependent on the reaction conditions and

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