7688-51-9Relevant articles and documents
Lithium and potassium bis(trimethylsilyl)amide: Utilizing non-nucleophilic bases as nitrogen sources
Bruening, Joerg
, p. 3187 - 3188 (1997)
Lithium and potassium bis(trimethylsilyl)amides are successfully utilized as nitrogen sources in palladium(0) catalyzed aminations of allylchloride.
Synthesis of bifunctional disiloxanes: Via subsequent hydrosilylation of alkenes and alkynes
Szyling, Jakub,Januszewski, Rafa?,Jankowska, Kamila,Walkowiak, J?drzej,Kownacki, Ireneusz,Franczyk, Adrian
supporting information, p. 4504 - 4507 (2021/05/17)
The first protocol for the synthesis of unsymmetrical bifunctional 1,1,3,3-tetramethyldisiloxane derivatives via subsequent hydrosilylation of alkenes and alkynes is presented. The methodology described has vast functional group tolerance and is extremely efficient towards the formation of novel disiloxane-based building blocks.
METHOD FOR PRODUCING SILANE COMPOUND HAVING BIS-SILYLAMINO GROUP
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Paragraph 0028, (2018/06/30)
PROBLEM TO BE SOLVED: To provide a method for producing a silane compound having a bis-silylamino group efficiently, stably, and in good yield. SOLUTION: A method for producing a silane compound having a bis-silylamino group represented by the formula (3) includes reacting a compound represented by the formula (2): HSiR8nX3-n (2) with a compound represented by the formula (1) in the presence of a platinum compound where the compound represented by the formula (1) having a content of a compound represented by the formula (4) of not greater than 5.0 mass% is used. In the formulae, R1 is a C1-18 bivalent hydrocarbon group, R1' is a C3-20 bivalent hydrocarbon group, R2-R8 and R9 are each independently a substituted or unsubstituted C1-20 monovalent hydrocarbon group, X is a halogen or OR9, and n is an integer of 0-2. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin: polar myosin II inhibitors with superior research tool properties
Verhasselt, Sigrid,Roman, Bart I.,De Wever, Olivier,Van Hecke, Kristof,Van Deun, Rik,Bracke, Marc E.,Stevens, Christian V.
supporting information, p. 2104 - 2118 (2017/03/11)
In search of myosin II inhibitors with superior research tool properties, a chemical optimization campaign of the blebbistatin scaffold was conducted in this paper. (S)-Blebbistatin is the best known small-molecule inhibitor of myosin II ATPase activity. Unfortunately, as a research tool this compound has several deficiencies: it is photolabile and (photo)toxic, has low water solubility, and its (fluorescent) precipitates interfere in (fluorescence) readouts. In view of obtaining tool compounds with improved properties, both enantiomers of a series of D-ring modified polar analogs were prepared. We identified (S)-3′-hydroxyblebbistatin (S)-2 and (S)-3′-aminoblebbistatin (S)-3 as two myosin II inhibitors with a 30-fold higher water solubility than (S)-blebbistatin. These molecules furthermore do not cause interference in (fluorescence) readouts. (S)-2 and (S)-3 thus are superior alternatives to (S)-blebbistatin as research tools to study myosin II.