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Cas Database

77-71-4

77-71-4

Identification

  • Product Name:5,5-Dimethylhydantoin

  • CAS Number: 77-71-4

  • EINECS:201-051-3

  • Molecular Weight:128.131

  • Molecular Formula: C5H8N2O2

  • HS Code:2933.21

  • Mol File:77-71-4.mol

Synonyms:Hydantoin,5,5-dimethyl- (6CI,7CI,8CI);4,4-Dimethyl-2,5-dioxoimidazolidine;5,5-Dimethyl-2,4-imidazolidinedione;DM Hydantoin;DMH;Dantoin 736;Dantoin DMH;Dimethylhydantoin;Fennosurf 300;NSC 8652;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:No signal word.

  • Hazard Statement:none

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:5,5-Dimethylhydantoin
  • Packaging:100g
  • Price:$ 135
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:5,5-Dimethylhydantoin >98.0%(T)
  • Packaging:500g
  • Price:$ 44
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:5,5-Dimethylhydantoin >98.0%(T)
  • Packaging:25g
  • Price:$ 15
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:5,5-Dimethylhydantoin 97%
  • Packaging:5 kg
  • Price:$ 392
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:5,5-Dimethylhydantoin 97%
  • Packaging:1 kg
  • Price:$ 144
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:5,5-Dimethylhydantoin 97%
  • Packaging:250 g
  • Price:$ 112
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:5,5-Dimethylhydantoin 97%
  • Packaging:1kg
  • Price:$ 82.6
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:5,5-Dimethylhydantoin 97%
  • Packaging:100g
  • Price:$ 24.3
  • Delivery:In stock
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  • Manufacture/Brand:Oakwood
  • Product Description:5,5-Dimethylimidazolidine-2,4-dione 97%
  • Packaging:100g
  • Price:$ 18
  • Delivery:In stock
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  • Manufacture/Brand:Frontier Specialty Chemicals
  • Product Description:5,5-Dimethylhydantoin 97%
  • Packaging:250g
  • Price:$ 34
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Relevant articles and documentsAll total 21 Articles be found

-

Bucherer,Brandt

, p. 145 ()

-

Synthesis and in vivo hypoglycemic activity of new imidazolidine-2,4-dione derivatives

Hussain, Abid,Kashif, Muhammad Kalim,Naseer, Muhammad Moazzam,Rana, Usman A.,Hameed, Shahid

, p. 7313 - 7326 (2015/09/29)

A series of new 3-arylsulfonylimidazolidine-2,4-diones (2a-2p) were synthesized by reacting imidazolidine-2,4-diones (1a-1e) with arylsulfonyl chlorides in the presence of triethyl amine. The imidazolidine-2,4-diones (1a-1e) were in turn synthesized from the corresponding ketones through Bucherer-Bergs reaction. All the synthesized compounds were characterized on the basis of their spectral (IR, 1H and 13C NMR and MS) and microanalytical data. The hypoglycemic activity of the compounds (2a-2p) was evaluated using alloxanized diabetic rat model. Compound 2a showed an excellent activity with a reduction in the blood glucose level of -286 ± 7 mg/dL after 5 h of drug administration as compared to -270 ± 8 mg/dL for glipizide. The hypoglycemic activity of compound 2b (-268 ± 9 mg/dL) was also comparable to the standard drug. However, only moderate activity was observed for compound 2e.

Fast halogenation of some N-heterocycles by means of N,N'-dihalo-5,5- dimethylhydantoin

Sandtorv, Alexander H.,Bjorsvik, Hans-Rene

, p. 499 - 507 (2013/05/08)

An instantaneous, selective and high-yielding halogenation process is reported. The method operates with imidazoles, pyrazoles, and indoles under benign reaction conditions. The developed process involves the use of N,N'-dihalo-5,5-dimethylhydantoins (halo=chlorine, bromine, iodine) as halogenation reagents that are activated by catalytic quantities of a strong Bronsted acid. Moreover, the halogenation process is switchable to produce either the mono- or di-halogenated products. Issues related to the reaction mechanism are investigated and a proposal for a reaction mechanism is disclosed.

Process route upstream and downstream products

Process route

potassium cyanide

potassium cyanide

ammonium carbonate
506-87-6,6721-33-1,10361-29-2

ammonium carbonate

acetone
67-64-1

acetone

5,5-dimethyl-imidazolidine-2,4-dione
77-71-4

5,5-dimethyl-imidazolidine-2,4-dione

Conditions
Conditions Yield
In water; at 120 ℃; for 0.533333h; under 15001.5 Torr; Flow reactor;
82%
potassium cyanide; ammonium carbonate; acetone; In ethanol; water; at 55 - 60 ℃;
With hydrogenchloride; In ethanol; water;
65%
acetone; With sodium metabisulfite;
potassium cyanide;
ammonium carbonate;
In ethanol; water; at 50 - 80 ℃; Reflux;
5,5-dimethyl-imidazolidine-2,4-dione
77-71-4

5,5-dimethyl-imidazolidine-2,4-dione

5-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-eth-(Z)-ylidene]-imidazolidine-2,4-dione
116730-53-1

5-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-eth-(Z)-ylidene]-imidazolidine-2,4-dione

Conditions
Conditions Yield
With potassium cyanide; In ethanol; water; at 50 ℃; for 24h;
62.5%
sodium cyanide
143-33-9,25596-52-5

sodium cyanide

acetone
67-64-1

acetone

5,5-dimethyl-imidazolidine-2,4-dione
77-71-4

5,5-dimethyl-imidazolidine-2,4-dione

Conditions
Conditions Yield
With ethanol; carbon dioxide; ammonia;
With water; ammonium carbonate;
With carbon dioxide; water; ammonium carbonate;
5,5-dimethyl-imidazolidine-2,4-dione
77-71-4

5,5-dimethyl-imidazolidine-2,4-dione

5-(D-threo-2,3,4-trihydroxybutylidene)imidazol-2,4-dione
116730-55-3

5-(D-threo-2,3,4-trihydroxybutylidene)imidazol-2,4-dione

Conditions
Conditions Yield
With potassium cyanide; In ethanol; water; at 50 ℃; for 24h;
15%
62.5%
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione
77-48-5

1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione

1α,3β,24(R)-triethoxycarbonyloxycholest-5-ene
79488-38-3

1α,3β,24(R)-triethoxycarbonyloxycholest-5-ene

5,5-dimethyl-imidazolidine-2,4-dione
77-71-4

5,5-dimethyl-imidazolidine-2,4-dione

Conditions
Conditions Yield
In hexane;
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione
77-48-5

1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione

(5-Cholesten-1α,3β-diol)-diacetat
35339-68-5

(5-Cholesten-1α,3β-diol)-diacetat

5,5-dimethyl-imidazolidine-2,4-dione
77-71-4

5,5-dimethyl-imidazolidine-2,4-dione

Conditions
Conditions Yield
In hexane;
1α,3β-diethoxycarbonyloxycholest-5-ene
79488-29-2

1α,3β-diethoxycarbonyloxycholest-5-ene

1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione
77-48-5

1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione

5,5-dimethyl-imidazolidine-2,4-dione
77-71-4

5,5-dimethyl-imidazolidine-2,4-dione

Conditions
Conditions Yield
In hexane;
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione
77-48-5

1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione

1α,3β,24-triacetoxycholest-5-ene
60934-50-1

1α,3β,24-triacetoxycholest-5-ene

5,5-dimethyl-imidazolidine-2,4-dione
77-71-4

5,5-dimethyl-imidazolidine-2,4-dione

Conditions
Conditions Yield
In hexane;
potassium cyanate
590-28-3

potassium cyanate

methyl 2-aminoisobutyrate hydrochloride
15028-41-8

methyl 2-aminoisobutyrate hydrochloride

5,5-dimethyl-imidazolidine-2,4-dione
77-71-4

5,5-dimethyl-imidazolidine-2,4-dione

Conditions
Conditions Yield
potassium cyanate; methyl 2-aminoisobutyrate hydrochloride; In water; Milling; Green chemistry;
With potassium carbonate; In water; Green chemistry;
92%
(3aR,5S,5aR,8aS,8bR)-2,2,7,7-Tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-carbaldehyde
4933-77-1

(3aR,5S,5aR,8aS,8bR)-2,2,7,7-Tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-carbaldehyde

5,5-dimethyl-imidazolidine-2,4-dione
77-71-4

5,5-dimethyl-imidazolidine-2,4-dione

5-(4,5-isopropylidene-L-gluconor-L-mannono-nitrile-6-yl)hydantoin
116730-74-6,116837-98-0

5-(4,5-isopropylidene-L-gluconor-L-mannono-nitrile-6-yl)hydantoin

5-<1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose-5(R)-yl>hydantoin
116730-68-8

5-<1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose-5(R)-yl>hydantoin

6-deoxy-1,2:3,4-di-O-isopropylidene-6-ureido-DL-glycero-α-D-galacto-heptopyranuronamide
116730-54-2,116730-69-9

6-deoxy-1,2:3,4-di-O-isopropylidene-6-ureido-DL-glycero-α-D-galacto-heptopyranuronamide

Conditions
Conditions Yield
With potassium cyanide; In ethanol; water; at 50 ℃; for 24h;
23%
15.7%
2%
45%

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