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Cas Database

77-89-4

77-89-4

Identification

  • Product Name:1,2,3-Propanetricarboxylicacid, 2-(acetyloxy)-, 1,2,3-triethyl ester

  • CAS Number: 77-89-4

  • EINECS:201-066-5

  • Molecular Weight:318.324

  • Molecular Formula: C14H22O8

  • HS Code:2918150000

  • Mol File:77-89-4.mol

Synonyms:1,2,3-Propanetricarboxylicacid, 2-(acetyloxy)-, triethyl ester (9CI);Citric acid, triethyl ester,acetate (6CI,7CI,8CI);ATEC;Acetyl triethyl citrate;Citroflex A 2;CitrofolAII;Morflex ATEC;NSC 3887;Triethyl 2-acetoxy-1,2,3-propanetricarboxylate;Triethyl acetylcitrate;

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Safety information and MSDS view more

  • Signal Word:Warning

  • Hazard Statement:H317 May cause an allergic skin reaction

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:O-Acetyl-
  • Packaging:10mg
  • Price:$ 460
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TRC
  • Product Description:Triethyl O-Acetylcitrate
  • Packaging:10g
  • Price:$ 120
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Triethyl O-Acetylcitrate >97.0%(GC)
  • Packaging:500g
  • Price:$ 45
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Triethyl O-Acetylcitrate >97.0%(GC)
  • Packaging:25g
  • Price:$ 22
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Triethyl 2-acetylcitrate 99%
  • Packaging:500ml
  • Price:$ 51.1
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Triethyl 2-acetylcitrate Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging:1g
  • Price:$ 72.8
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Acetyltriethyl citrate United States Pharmacopeia (USP) Reference Standard
  • Packaging:500mg
  • Price:$ 414
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:Triethyl2-acetoxypropane-1,2,3-tricarboxylate 95+%
  • Packaging:500g
  • Price:$ 97
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:O-ACETYLCITRIC ACID TRIETHYL ESTER 95.00%
  • Packaging:500G
  • Price:$ 4292.53
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:O-ACETYLCITRIC ACID TRIETHYL ESTER 95.00%
  • Packaging:25G
  • Price:$ 1109.3
  • Delivery:In stock
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Relevant articles and documentsAll total 4 Articles be found

manufacturing method of acetyl-triethyl citrate using solid acid catalysts

-

Paragraph 0044-0048; 0079, (2018/04/20)

The present invention relates to a method for producing acetyl triethyl citrate using a solid acid catalyst and, more specifically, to a method for producing acetyl triethyl citrate capable of increasing conversion rate of reactants while improving yield of acetyl triethyl citrate using zeolite as a catalyst. To this end, the method for producing the acetyl triethyl citrate comprises the following steps: an insertion step for inserting triethyl citrate and acetic anhydride into a reactor; and a reaction step for producing acetyl triethyl citrate by carrying out a reaction between triethyl citrate and acetic anhydride in the presence of the solid acid catalyst.COPYRIGHT KIPO 2017

4-(N,N -dimethylamino)pyridine hydrochloride as a recyclable catalyst for acylation of inert alcohols: Substrate scope and reaction mechanism

Liu, Zhihui,Ma, Qiaoqiao,Liu, Yuxiu,Wang, Qingmin

supporting information, p. 236 - 239 (2014/01/23)

4-(N,N-Dimethylamino)pyridine hydrochloride (DMAP·HCl), a DMAP salt with the simplest structure, was used as a recyclable catalyst for the acylation of inert alcohols and phenols under base-free conditions. The reaction mechanism was investigated in detail for the first time; DMAP·HCl and the acylating reagent directly formed N-acyl-4-(N′,N′-dimethylamino) pyridine chloride, which was attacked by the nucleophilic substrate to form a transient intermediate that released the acylation product and regenerated the DMAP·HCl catalyst.

SKIN EXTERNAL PREPARATIONS AND COSMETICS

-

, (2010/12/29)

An object of the present invention is to provide skin external preparations and cosmetics which contain a branched acyl carnitine and have excellent formulation stability. A skin external preparation of the present invention includes a carnitine derivative represented by the following Formula (1) and/or a carnitine derivative salt represented by the following Formula (2), and an amphoteric surfactant. In Formula (1), R1 and R2 are each independently a C1-18 optionally branched, saturated or unsaturated aliphatic hydrocarbon group. In Formula (2), R1 and R2 are the same as in Formula (1), X? is a specific anion and Y+ is a specific cation.

Synthesis of 2-Oxo-2H-pyran-5-carboxylate Derivatives

Kvita, Vratislav

, p. 411 - 416 (2007/10/02)

3-Substituted diethyl pent-2-enedioates are easily formylated by means of ethyl formate/TiCl4/4-methylmorpholine to produce the ethoxymethylene derivatives, which are smoothly cyclized either with HCOOH or PPA to the corresponding 2-oxo-2H-pyran-5-carboxylate derivatives.

Process route upstream and downstream products

Process route

citric acid triethyl ester
77-93-0

citric acid triethyl ester

acetic anhydride
108-24-7

acetic anhydride

triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

Conditions
Conditions Yield
With 4-(dimethylamino)pyridine hydrochloride; at 110 ℃; for 8h;
90%
sulfuric acid; at 80 ℃; for 3h;
88%
With H-type zeolite catalyst; at 60 - 120 ℃; for 2.83333h; under 760.051 Torr; Reagent/catalyst; Sealed tube; Inert atmosphere;
unter kontinuierlicher Entfernung der entstehenden Essigsaeure;
citric acid triethyl ester
77-93-0

citric acid triethyl ester

acetyl chloride
75-36-5

acetyl chloride

triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

Conditions
Conditions Yield
triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

Conditions
Conditions Yield
triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

Diethyl-3-(ethoxycarbonyl)pent-2-endioat
5349-99-5

Diethyl-3-(ethoxycarbonyl)pent-2-endioat

Conditions
Conditions Yield
at 275 ℃; for 1.5h;
89%
at 270 ℃; for 0.4h; under 760.051 Torr;
74%
at 250 - 280 ℃;
triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
Conditions Yield
at 250 - 280 ℃; ueberdestilliert die Essigsaeure, dann verseift man mit konz.Salzsaeure und destilliert diese unter vermindertem Druck ab;
methanol
67-56-1

methanol

triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

<i>tert</i>-butylamine
75-64-9

tert-butylamine

trimethyl citrate
1587-20-8

trimethyl citrate

citric acid triethyl ester
77-93-0

citric acid triethyl ester

dimethyl 3-(tertbutylcarbamoyl)-3-acetoxy-pentanedioate
1242516-65-9

dimethyl 3-(tertbutylcarbamoyl)-3-acetoxy-pentanedioate

3-(tertbutylcarbamoyl)-3-acetoxy-pentanedioic acid
1242516-64-8

3-(tertbutylcarbamoyl)-3-acetoxy-pentanedioic acid

Conditions
Conditions Yield
at 20 ℃;
triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

n-propylacetamide
5331-48-6

n-propylacetamide

(Z)-3-acetyl-5-oxo-N-propylhex-2-enamide
1242516-61-5

(Z)-3-acetyl-5-oxo-N-propylhex-2-enamide

(Z)-3-((propylcarbamoyl)-methylene)-4-oxopentanoic acid
1242516-60-4

(Z)-3-((propylcarbamoyl)-methylene)-4-oxopentanoic acid

(Z)-3,4-bis(propylcarbamoyl)but-3-enoic acid
1242516-62-6

(Z)-3,4-bis(propylcarbamoyl)but-3-enoic acid

1,2,3-tris(propylcarbamoyl)propyl-2-yl acetate

1,2,3-tris(propylcarbamoyl)propyl-2-yl acetate

Conditions
Conditions Yield
In methanol; at 20 ℃;
triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

N-butylamine
109-73-9,85404-21-3

N-butylamine

N-butylacetamide
1119-49-9

N-butylacetamide

1,2,3-tris(butylcarbamoyl)propan-2yl acetate
1242516-63-7

1,2,3-tris(butylcarbamoyl)propan-2yl acetate

Conditions
Conditions Yield
In methanol; at 20 ℃;
triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

2,6-dihydroxy-isonicotinic acid amide
14533-64-3

2,6-dihydroxy-isonicotinic acid amide

Conditions
Conditions Yield
With ammonium hydroxide;

Global suppliers and manufacturers

Global( 109) Suppliers
  • Company Name
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  • Kono Chem Co.,Ltd
  • Business Type:Other
  • Contact Tel:86-29-86107037-8015
  • Emails:info@konochemical.com
  • Main Products:82
  • Country:China (Mainland)
  • EAST CHEMSOURCES LIMITED
  • Business Type:Manufacturers
  • Contact Tel:86-532-81906761
  • Emails:josen@eastchem-cn.com
  • Main Products:97
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • LIDE PHARMACEUTICALS LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-25-58409506
  • Emails:lide@lidepharma.com
  • Main Products:56
  • Country:China (Mainland)
  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-29-86470566
  • Emails:sales@bloomtechz.com
  • Main Products:79
  • Country:China (Mainland)
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:88
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:56
  • Country:China (Mainland)
  • Leader Biochemical Group
  • Business Type:Lab/Research institutions
  • Contact Tel:86-029-68895030
  • Emails:info@leader-biogroup.com
  • Main Products:62
  • Country:China (Mainland)
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