Welcome to LookChem.com Sign In|Join Free

Cas Database

7710-42-1

7710-42-1

Identification

  • Product Name:1,3,5-Triazine-2,4,6-triamine, N,N-dimethyl-N',N''-diphenyl-

  • CAS Number: 7710-42-1

  • EINECS:

  • Molecular Weight:306.37

  • Molecular Formula: C17H18N6

  • HS Code:

  • Mol File:7710-42-1.mol

Synonyms:

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase

Relevant articles and documentsAll total 2 Articles be found

Heterocyclic IDH mutant inhibitor, preparation method and application thereof

-

, (2020/09/23)

The invention discloses a heterocyclic IDH mutant inhibitor, a preparation method and application thereof, belongs to the field of medicines, and particularly relates to a s-triazine compound with structural characteristics of a general formula (I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition, a preparation method of the s-triazine compound, and application of the s-triazine compound or the pharmaceutically acceptable salt and the pharmaceutical composition as isocitrate dehydrogenase 2 (IDH2) mutant inhibitors. The compound disclosed by the invention has an obvious inhibiting effect on the activity of an IDH2 mutant (mIDH2), can effectively inhibit the process of catalyzing alpha-ketoglutaric acid to generate 2-hydroxyglutaric acid by the mIDH2, and can be used for preventing and/or treating various related diseases including cancers caused by IDH2 mutation.

Synthesis of 2,4-Bisalkyl(aryl)amino-6-cyanamino-s-triazines

Freiberg, Renate,Bulka, Ehrenfried

, p. 471 - 478 (2007/10/02)

Reaction of 2,4-bisalkyl(aryl)amino-6-chloro-s-triazines with disodiumcyanamide to 2,4-bisalkyl(aryl)amino-6-cyanamino-s-triazines (3a-g) strongly depends on the solvent used.In dimethylformamide by-products predominate.The best results are found in dimet

Process route upstream and downstream products

Process route

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

isopropylamine
75-31-0

isopropylamine

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine
7710-42-1

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine

Conditions
Conditions Yield
With sodium hydrogencarbonate; In tetrahydrofuran; at 70 ℃;
75%
6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

N,N-dimethyl-formamide
68-12-2,33513-42-7

N,N-dimethyl-formamide

2,4-Bisanilino-6-cyanamino-1,3,5-triazin
100033-29-2

2,4-Bisanilino-6-cyanamino-1,3,5-triazin

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine
7710-42-1

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine

Conditions
Conditions Yield
With disodium cyanamide; In water; at 135 ℃; for 0.416667h;
90%
10%
6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

dimethyl amine
124-40-3

dimethyl amine

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine
7710-42-1

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine

Conditions
Conditions Yield
With water; sodium carbonate; for 1.5h; Heating;
100%
aniline
62-53-3

aniline

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine
7710-42-1

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran / 0.03 h / Cooling with ice
1.2: 4.5 h / 20 °C / Cooling with ice
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.03 h
2.2: 6 h / 20 °C
3.1: sodium hydrogencarbonate / tetrahydrofuran / 70 °C
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
2-phenylamino-4,6-dichloro-s-triazine
2272-40-4

2-phenylamino-4,6-dichloro-s-triazine

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine
7710-42-1

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.03 h
1.2: 6 h / 20 °C
2.1: sodium hydrogencarbonate / tetrahydrofuran / 70 °C
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

isopropylamine
75-31-0

isopropylamine

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine
7710-42-1

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine

Conditions
Conditions Yield
With sodium hydrogencarbonate; In tetrahydrofuran; at 70 ℃;
75%
6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

N,N-dimethyl-formamide
68-12-2,33513-42-7

N,N-dimethyl-formamide

2,4-Bisanilino-6-cyanamino-1,3,5-triazin
100033-29-2

2,4-Bisanilino-6-cyanamino-1,3,5-triazin

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine
7710-42-1

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine

Conditions
Conditions Yield
With disodium cyanamide; In water; at 135 ℃; for 0.416667h;
90%
10%
6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

dimethyl amine
124-40-3

dimethyl amine

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine
7710-42-1

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine

Conditions
Conditions Yield
With water; sodium carbonate; for 1.5h; Heating;
100%
aniline
62-53-3

aniline

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine
7710-42-1

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran / 0.03 h / Cooling with ice
1.2: 4.5 h / 20 °C / Cooling with ice
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.03 h
2.2: 6 h / 20 °C
3.1: sodium hydrogencarbonate / tetrahydrofuran / 70 °C
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
2-phenylamino-4,6-dichloro-s-triazine
2272-40-4

2-phenylamino-4,6-dichloro-s-triazine

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine
7710-42-1

N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.03 h
1.2: 6 h / 20 °C
2.1: sodium hydrogencarbonate / tetrahydrofuran / 70 °C
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

Global suppliers and manufacturers

Global( 0) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 7710-42-1
Post Buying Request Now
close
Remarks: The blank with*must be completed