77169-11-0Relevant articles and documents
AMIDE COMPOUNDS AND MEDICINAL USE THEREOF
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Page 44, (2010/01/31)
The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.
CONVERSION DE L'ACETYL-5 URACILE EN DERIVES PYRAZOLIQUES PAR L'HYDRAZINE ET LES HYDRAZINES MONOSUBSTITUEES
Bajnati, Abdelilah,Hubert-Habart, Michel
, p. 540 - 547 (2007/10/02)
5-Acetyl uracile 1 is easily transformed by hydrazine and methylhydrazine into 4-allophanoyl-3-methyl pyrazole 2 (R=H) and 4-allophanoyl-1,3-dimethyl pyrazole 2 (R=CH3).The pyrazoles 2, in boiling butanol and in the presence of hydrochloric acid lead resp