7736-25-6

Basic information

• Product Name: 2-(pent-4-en-1-yl)-1H-isoindole-1,3(2H)-dione
• Synonyms: 1H-isoindole-1,3(2H)-dione, 2-(4-penten-1-yl)-; 1H-isoindole-1,3(2H)-dione, 2-(4-pentenyl)-; 2-(Pent-4-en-1-yl)-1H-isoindole-1,3(2H)-dione; 2-pent-4-en-1-yl-1H-isoindole-1,3(2H)-dione
• CAS NO: 7736-25-6
• Molecular Formula: C₁₃H₁₃NO₂
• Molecular Weight: 215.2478
• Mol File: 7736-25-6.mol
• Article Data: 62

Chemical Properties

• Boiling Point: 327.2°C at 760 mmHg
• Flash Point: 138.6°C
• Density: 1.164g/cm³
• Vapor Pressure: 0.000205mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 2-(pent-4-en-1-yl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(pent-4-en-1-yl)-1H-isoindole-1,3(2H)-dione(7736-25-6)
• EPA Substance Registry System: 2-(pent-4-en-1-yl)-1H-isoindole-1,3(2H)-dione(7736-25-6)

Safety Data

• Hazardous Substances Data: 7736-25-6(Hazardous Substances Data)

Usage

General Description

2-(pent-4-en-1-yl)-1H-isoindole-1,3(2H)-dione is a chemical compound with the molecular formula C14H15NO2. It is an isoindole-1,3(2H)-dione derivative with a pent-4-en-1-yl group attached to the nitrogen atom. 2-(pent-4-en-1-yl)-1H-isoindole-1,3(2H)-dione is a yellow crystalline solid that is insoluble in water but soluble in organic solvents. It is used as a building block in organic synthesis and can be found in some pharmaceuticals and agricultural chemicals. Additionally, it has been studied for its potential biological activities, including as a potential anti-cancer and anti-inflammatory agent.

Upstream product

• 1074-82-4 potassium phtalimide 
• 1119-51-3 bromopentene 
• 5390-04-5 pent-1-yn-5-ol 
• 124-63-0 methanesulfonyl chloride 
• 136918-14-4 phthalimide 
• 928-50-7 5-chloropent-1-ene 
• 64818-35-5 4-pentenyl mesylate 
• 6097-07-0 N-(pent-4-ynyl)phthalimide 
• 954-81-4 N-(5-bromopentyl)phthalimide 
• 821-09-0 n-Pent-4-enyl alcohol 
• 19300-54-0 toluene-4-sulfonic acid pent-4-enyl ester 
• 574-98-1 2-(2-bromoethyl)isoindoline-1,3-dione 
• 145732-26-9 2-(allylthio)-1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilane 
• 4443-26-9 6-phthalimidohexanoic acid 

Downstream Products

• 93272-50-5 2-[4-Hydroxy-5-(2-nitro-imidazol-1-yl)-pentyl]-isoindole-1,3-dione 
• 1251739-78-2 C₂₈H₃₀N₂O₅S 
• 1234715-16-2 C₂₂H₂₃NO₅ 
• 1234715-00-4 C₂₁H₂₁NO₄ 
• 1234714-89-6 C₂₂H₂₅NO₄ 
• 1350662-65-5 C₂₉H₂₉NO₄ 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 22537-07-1 4-pentenyl-1-amine 
• 71510-42-4 2-(6-oxoheptyl)isoindoline-1,3-dione 
• 86136-88-1 pent-4-enylcarbamic acid benzyl ester 
• 886576-69-8 4-methyl-N-(pent-4-enyl)benzamide 
• 886576-75-6 benzyl 2-methylpyrrolidine-1-carboxylate 
• 93272-49-2 2-(3-(oxiran-2-yl)propyl)isoindoline-1,3-dione 
• 59353-62-7 4-bromo-1-phthalimidopentane 

Relevant articles and documents

Synthesis of a library of tricyclic azepinoisoindolinones

Hydrozirconation of 1-hexyne, the addition to in situ prepared N-acyliminium species, and ring-closing metathesis (RCM) were key steps in the preparation of a tricyclic isoindolinone scaffold. An unusual alkene isomerization process during the RCM was identified and studied in some detail. Chemical diversification for library synthesis was achieved by a subsequent alkene epoxidation and zinc-mediated aminolysis reaction. The resulting library products provided selective hits among a large number of high-throughput screens reported in PubChem, thus illustrating the utility of the novel scaffold.

A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF

The present invention relates to a class of bifunctional chimeric heterocyclic compounds for targeted degradation of androgen receptors and use thereof, and specifically provides a compound of formula (I), or an isotopic compound thereof, or an optical isomer thereof, or a tautomer thereof, or a pharmacologically acceptable salt thereof, or a prodrug thereof, or a solvate thereof, wherein ARB is an androgen receptor recognition/binding part, L is a link part, and U is a ubiquitin protease recognition/binding part; and the three parts are connected by means of chemical bonds. The compound can perform the targeted degradation on androgen receptors in prostate cancer cells, and suppress the proliferation of the prostate cancer cells, and also show good metabolic stability and pharmacokinetic properties. The compound has good application prospect in the preparation of targeted chimeras for protein degradation of androgen receptors and in the preparation of drugs for treating the related diseases regulated by the androgen receptors.

Nickel-Catalyzed Hydrosilylation of Terminal Alkenes with Primary Silanes via Electrophilic Silicon-Hydrogen Bond Activation

We report a simple and effective nickel-based catalytic system, NiCl2·6H2O/tBuOK, for the electrophilically activated hydrosilylation of terminal alkenes with primary silanes. This protocol provides excellent performance under mild reaction conditions: ex

Highly selective hydrosilylation of equilibrating allylic azides

The Pt-catalyzed hydrosilylation of equilibrating allylic azides is reported. The reaction provides only one out of four possible hydrosilylation products in good yields and with very high chemoselectivity (alk-1-enevs.alk-2-ene), regioselectivity (linearvs.branched), and excellent functional group tolerance.