77519-55-2

Basic information

• Product Name: 2-OXO-4-PHENYL-PYRROLIDINE-3-CARBOXYLIC ACID
• Synonyms: 2-OXO-4-PHENYL-PYRROLIDINE-3-CARBOXYLIC ACID;AKOS GLO-BB-239;3-pyrrolidinecarboxylic acid, 2-oxo-4-phenyl-;Albb-009275;2-oxo-4-phenylpyrrolidine-3-carboxylic acid(SALTDATA: FREE);2-keto-4-phenyl-pyrrolidine-3-carboxylic acid
• CAS NO: 77519-55-2
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.21
• Mol File: 77519-55-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 501.6°C at 760 mmHg
• Flash Point: 257.2°C
• Appearance: /
• Density: 1.301g/cm³
• Vapor Pressure: 6.99E-11mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-OXO-4-PHENYL-PYRROLIDINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-OXO-4-PHENYL-PYRROLIDINE-3-CARBOXYLIC ACID(77519-55-2)
• EPA Substance Registry System: 2-OXO-4-PHENYL-PYRROLIDINE-3-CARBOXYLIC ACID(77519-55-2)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 77519-55-2(Hazardous Substances Data)

Usage

General Description

2-OXO-4-PHENYL-PYRROLIDINE-3-CARBOXYLIC ACID is a chemical compound that belongs to the class of pyrrolidine carboxylic acids. It is a white crystalline powder that is primarily used in the field of organic synthesis and pharmaceutical research. 2-OXO-4-PHENYL-PYRROLIDINE-3-CARBOXYLIC ACID has various applications, including as a building block for the synthesis of pharmaceutical drugs and as a reagent for chemical reactions. Additionally, it has been studied for its potential biological activities and therapeutic properties. Its molecular structure and properties make it an important component in the development of new drugs and pharmaceutical products.

InChI:InChI=1/C11H11NO3/c13-10-9(11(14)15)8(6-12-10)7-4-2-1-3-5-7/h1-5,8-9H,6H2,(H,12,13)(H,14,15)

Upstream product

• 52450-32-5 2-oxo-4-phenyl-3-ethoxycarbonylpyrrolidine 
• 5292-53-5 diethyl benzalmalonate 
• 185067-05-4 ethyl 2-carbethoxy-3-cyano-3-phenylpropionate 
• 52450-32-5 Ethyl (E)-2-oxo-4-phenylpyrrolidine-3-carboxylate 
• 100-52-7 benzaldehyde 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 
• 55790-16-4 (2-nitro-1-phenyl-ethyl)-malonic acid dimethyl ester 
• 55790-17-5 3-methoxycarbonyl-4-phenyl-2-pyrrolidone 

Downstream Products

• 138812-85-8 (3S,4S)-N-<(1R)-2-Hydroxy-1-phenylethyl>-2-oxo-4-phenylpyrrolidine-3-carboxamide 
• 138782-42-0 (3R,4R)-N-<(1R)-2-Hydroxy-1-phenylethyl>-2-oxo-4-phenylpyrrolidine-3-carboxamide 
• 71657-88-0 (4R)-4-phenyl-2-pyrrolidone 
• 62624-45-7 (S)-4-phenyl-1-tosylpyrrolidin-2-one 
• 77472-73-2 N-(1-Adamantyl)-2-oxo-4-phenylpyrrolidine-1-acetamide 
• 77472-74-3 N-(2-Adamantyl)2-oxo-4-phenylpyrrolidine-1-acetamide 
• 77472-72-1 N-Cyclohexyl-2-oxo-4-phenylpyrrolidine-1-acetamide 
• 77472-71-0 2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide 
• 70291-40-6 2-oxo-4-phenyl-1-pyrrolidineacetic acid, ethyl ester 
• 77472-70-9 (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide 
• 67118-34-7 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetic acid 
• 128372-78-1 (+)-(R)-1-tert-Butoxycarbonyl-4-phenyl-2-pyrrolidinone 
• 128372-78-1 (-)-(S)-1-tert-Butoxycarbonyl-4-phenyl-2-pyrrolidinone 
• 62624-46-8 (S)-(+)-3-phenylpyrrolidine 

Relevant articles and documents

Efficient synthesis of β-aryl-γ-lactams and their resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen

An efficient synthesis of enantiomerically-pure β-aryl-γ-lactams is described. The principal feature of this synthesis is the practical resolution of β-aryl-γ-lactams with (S)-Naproxen. The procedure is based on the Michael addition of nitromethane to benzylidenemalonates, which was easily obtained, followed by the reduction of the γ-nitroester in the presence of Raney nickel and the subsequent saponification/decarboxylation reaction. The utility of this methodology was highlighted by the preparation of enantiomerically-pure (R)- and (S)-Baclofen hydrochloride.

PYRROLIDINE DERIVATIVE OR SALT THEREOF

[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).

THE SYNTHESIS AND ANTISPASMODIC ACTIVITY OF 4-PHENYLPYRROLIDONE-2-ACETAMIDES

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