777-33-3

Basic information

• Product Name: (S)-(-)-2-(TRIFLUOROACETAMIDO)SUCCINIC ANHYDRIDE
• Synonyms: TFA-L-ASPARTIC ACID ANHYDRIDE;(S)-2-TRIFLUOROACETAMIDESUCCINIC ANHYDRIDE;(S)-(-)-2-(TRIFLUOROACETAMIDO)SUCCINIC ANHYDRIDE;N-TRIFLUOROACETYL-L-ASPARTIC ACID ANHYDRIDE;N-TRIFLUOROACETYL-L-ASPARTIC ANHYDRIDE;(S)-(-)-2-Trifluoroacetamidosuccinic anhydride, N-Trifluoroacetyl-L-aspartic acid anhydride;(S)-(-)-2-(TrifluoroacetaMido)succinic anhydride 97%;(S)-(-)-2-(trifluoroacetamido)succinic anhydride, N-trifluoroacetyl aspartic anhydride
• CAS NO: 777-33-3
• Molecular Formula: C₆H₄F₃NO₄
• Molecular Weight: 211.1
• Product Categories: Aromatic Halides (substituted)
• Mol File: 777-33-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 131-132 °C(lit.)
• Boiling Point: 379.225°C at 760 mmHg
• Flash Point: 183.149°C
• Appearance: /
• Density: 1.604g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.428
• Storage Temp.: 2-8°C
• PKA: 8?+-.0.20(Predicted)
• CAS DataBase Reference: (S)-(-)-2-(TRIFLUOROACETAMIDO)SUCCINIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-2-(TRIFLUOROACETAMIDO)SUCCINIC ANHYDRIDE(777-33-3)
• EPA Substance Registry System: (S)-(-)-2-(TRIFLUOROACETAMIDO)SUCCINIC ANHYDRIDE(777-33-3)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 36-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 777-33-3(Hazardous Substances Data)

Usage

Uses

Useful in the synthesis of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, a potent dopamine agonist. Used in the synthesis of sweetening agents, such as N-trifluoroacetyl-L-aspartic acid α-amides and α-anilides.

InChI:InChI=1/C6H4F3NO4/c7-6(8,9)5(13)10-2-1-3(11)14-4(2)12/h2H,1H2,(H,10,13)/t2-/m0/s1

Upstream product

• 56-84-8 L-Aspartic acid 
• 407-25-0 trifluoroacetic anhydride 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 39219-30-2 trifluoroaacetyl-α-L-aspartyl-p-cyanoanilide 
• 1744-28-1 N-Trifluoracetyl-L-asparaginsaeure-α-benzylester 
• 92398-78-2 trifluoroacetyl-α-L-aspartyl-2,3-dinitroanilide 
• 92398-81-7 trifluoroacetyl-α-L-aspartyl-3-methyl-4-nitroanilide 
• 92398-77-1 trifluoroacetyl-α-L-aspartyl-3,4-dinitroanilide 
• 92398-75-9 trifluoroacetyl-α-L-aspartyl-3-nitro-2-methylanilide 
• 41567-05-9 trifluoroacetyl-α-L-aspartyl-p-toluidide 
• 137589-08-3 (S)-4-(4-methoxyphenyl)-4-oxo-2-trifluoroacetylaminobutanoic acid 
• 92398-70-4 trifluoroacetyl-α-L-aspartyl-o-nitroanilide 
• 92398-79-3 trifluoroacetyl-α-L-aspartyl-2-nitro-4-chloroanilide 
• 48193-99-3 trifluoroacetyl-α-L-aspartyl-o-chloroanilide 

Relevant articles and documents

GRANZYME B DIRECTED IMAGING AND THERAPY

Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.

Regioselective opening of unsymmetrical cyclic anhydrides: Synthesis of N-glycosylated isoasparagine and isoglutamine conjugates

N-Glycopeptide mimetic with N-glycosylated isoasparagine and isoglutamine conjugates were synthesized by regioselective opening of unsymmetrical cyclic anhydride derivatives of l-aspartic acid and l-glutamic acid, using per-O-acetylated β-d-glycopyranosyl amine. The α-chloro derivative gave a mixture of asparagine and isoasparagine linked glycoconjugates, whereas the trifluoroacetamide derivatives gave predominantly the isoasparagine and isoglutamine linked glycoconjugates as the product. The X-ray crystal structure of the α-chloro isoasparagine linked glycoconjugate showed unique pattern of hydrogen bonding. This journal is the Partner Organisations 2014.

Regioselective Reductions of Diacids: Aspartic Acid to Homoserine

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