77738-21-7

Basic information

• Product Name: Propanedioic acid, [(2-chlorophenyl)methyl]-, diethyl ester
• CAS NO: 77738-21-7
• Molecular Formula: C14H17ClO4
• Molecular Weight: 284.74
• Mol File: 77738-21-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [(2-chlorophenyl)methyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [(2-chlorophenyl)methyl]-, diethyl ester(77738-21-7)
• EPA Substance Registry System: Propanedioic acid, [(2-chlorophenyl)methyl]-, diethyl ester(77738-21-7)

Safety Data

• Hazardous Substances Data: 77738-21-7(Hazardous Substances Data)

Upstream product

• 996-82-7 sodium diethylmalonate 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 105-53-3 diethyl malonate 
• 64-17-5 ethanol 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 89-98-5 2-chloro-benzaldehyde 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 877663-07-5 2-(2-chloro-benzyl)-2-(1H-indol-3-ylmethyl)-malonic acid diethyl ester 
• 113961-97-0 ethyl 2-amino-3-(2-chlorophenyl)propanoate 
• 104296-59-5 5-(2-chloro-benzyl)-5-methyl-barbituric acid 
• 104296-58-4 5-(2-chloro-benzyl)-5-methyl-2-thio-barbituric acid 
• 108842-16-6 (2-chloro-benzyl)-methyl-malonic acid diethyl ester 
• 1643-28-3 3-(2-chlorophenyl)propanoic acid 
• 75954-10-8 6-(o-chlorobenzyl)-5H-2,3,6,7-tetrahydro-5,7-dioxothiazolo[3,2-a]pyrimidine 
• 14091-11-3 rac-2-chlorophenylalanine 

Relevant articles and documents

Aryltrifluoromethylative cyclization of unactivated alkenes by the use of PhICF3Cl under catalyst-free conditions

A concise and catalyst-free aryltrifluoromethylative cyclization of unactivated alkenes has been developed herein. The use of PhICF3Cl as a powerful trifluoromethylating agent allows easy transformations. A set of trifluoroethylated carbocycles and aza-hereocycles were efficiently synthesized in good yield and selectivity. A broad substrate scope, mild reaction conditions, and easy operation would make this method well-suited for applications.

Synthesis and insecticidal activity of mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety

Mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety were designed, synthesized, and evaluated for their insecticidal activity. Some of the title compounds showed remarkable insecticidal properties against Aphis craccivora. Compound I13 exhibited satisfactory insecticidal activity against A. craccivora. Meanwhile, label-free proteomics analysis of compound I13 treatment identified a total of 821 proteins. Of these, 35 proteins were up-regulated, whereas 108 proteins were down-regulated. Differential expressions of these proteins reflected a change in cellular structure and metabolism.

Catalytic direct arylation with aryl chlorides, bromides, and iodides: Intramolecular studies leading to new intermolecular reactions

A catalyst for the intramolecular direct arylation of a broad range of simple and heterocyclic arenes with aryl iodides, bromides, and chlorides has been developed. These reactions occur in excellent yield and are highly selective. Studies with aryl iodides substrates revealed that catalyst poisoning occurs due to the accumulation of iodide in the reaction media. This can be overcome by the addition of silver salts which also permits these reactions to occur at lower temperature. The utility of the methodology is illustrated by a rapid synthesis of a carbazole natural product and by the synthesis of sterically encumbered tetra-ortho-substituted biaryls via ring-opening reactions of the direct arylation products. Mechanistic investigations have provided insight into the catalyst's mode of action and show the presence of a kinetically significant C-H bond cleavage in palladium-catalyzed direct arylation of simple arenes. Knowledge garnered from these studies has led to the development of new intermolecular arylation reactions with previously inaccessible arenes, opening the door for the development of other new direct arylation processes.