77744-45-7Relevant articles and documents
A unified synthesis of cyclic ethers or lactones via Pd-catalyzed intramolecular O-functionalization of sp3C[sbnd]H bonds
Wang, Haifeng,Niu, Youhong,Zhang, Guoying,Ye, Xin-Shan
supporting information, p. 4544 - 4548 (2016/09/23)
A general approach for the synthesis of lactones or cyclic ethers via Pd-catalyzed C(sp3)[sbnd]H activation and intramolecular C[sbnd]O functionalization starting from carboxylic acids or alcohols using the bidentate directing group has been de
12 MEMBERED-RING MACROLACTAM DERIVATIVES
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, (2009/01/24)
There provided a 12-membered-ring macrolactam derivative having antitumor activity: A compound represented by Formula (1) or a salt thereof. In this Formula, R1 is a hydrogen atom, a C1-6 alkyl group, a C1-6 alkylcarbonyl
Template-Driven Macrolide Closures.
Rastetter, William H.,Phillion, Dennis P.
, p. 3209 - 3214 (2007/10/02)
Thiol-functionalized crown ethers serve as reagents for macrolide closures.The thioesters derived from these crown ethers and ω-hydroxy carboxylic acids yield macrolides when treated with potassium tert-butoxide.The cyclization reaction proceeds via a templated conformation in which the ω-alkoxide is held proximate to the thioester through ionic bonding to the crown-bound potassium cation.Variations in crown ether structure in the series 1-4 show that the criterion of proximate binding is necessary but not sufficient to ensure efficient macrolide closure.The optimal crown ether reagent is thought to provide transition-state stabilization for the attack of the alkoxide on the thioester carbonyl by situating the carbonyl oxygen immediately adjacent to the crown-bound potassium cation.