778642-53-8

Basic information

• Product Name: 4-[4-(benzyloxy)phenyl]-1,2,3,6-tetrahydropyridine
• Synonyms: 4-[4-(benzyloxy)phenyl]-1,2,3,6-tetrahydropyridine
• CAS NO: 778642-53-8
• Molecular Formula: C₁₈H₁₉NO
• Molecular Weight: 265.34956
• Mol File: 778642-53-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[4-(benzyloxy)phenyl]-1,2,3,6-tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(benzyloxy)phenyl]-1,2,3,6-tetrahydropyridine(778642-53-8)
• EPA Substance Registry System: 4-[4-(benzyloxy)phenyl]-1,2,3,6-tetrahydropyridine(778642-53-8)

Safety Data

• Hazardous Substances Data: 778642-53-8(Hazardous Substances Data)

Upstream product

• 302924-63-6 1,1-dimethylethyl 4-hydroxy-4-{4-[(phenylmethyl)oxy]phenyl}-1-piperidinecarboxylate 

Downstream Products

• 778642-54-9 4-{4-[(phenylmethyl)oxy]phenyl}-1-(tetrahydro-2H-pyran-4-ylcarbonyl)-1,2,3,6-tetrahydropyridine 

Relevant articles and documents

4- (4-(HETEROCYCLYLALKOXY}PHENYL)-1-(HETEROCYCLYL-CARBONYL)PIPERIDINE DERIVATIVES AND RELATED COMPOUNDS AS HISTAMINE H3 ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISEASES SUCH AS ALZHEIMER’S

The present invention provides, in a first aspect, a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein: R1 represents -C1-6 alkyl-O-C1-6 alkyl, -C3-8 cycloalkyl, aryl, heterocyclyl, heteroaryl and other groups; X represents a bond, O, CO, OCH2, CH2O or SO2; Z represents CO, CONR10 or SO2; R10 represents hydrogen, C1-6 alkyl, -C3-8 cycloalkyl, aryl, heterocyclyl, heteroaryl; A represents a single or a double bond; m and n independently represent 0, 1 or 2; R2 represents hydrogen, C1-6 alkyl or C1-6 alkoxy; R3 represents halogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, cyano, amino, -COC1-6 alkyl, -SO2C1-6 alkyl or trifluoromethyl; R4 represents -(CH2)q-NR11R12 or a group of formula (i) wherein all the other substituents are as defined in claim 1. Compounds of formula (I) and their pharmaceutically acceptable salts have affinity for and are antagonists and/or inverse agonists of the histamine H3 receptor and are believed to be of potential use in the treatment of neurological diseases including Alzheimer's disease.