77868-40-7

Basic information

• Product Name: N-DesMethyl IoMeprol
• Synonyms: N-DesMethyl IoMeprol;N,N'-Bis(2,3-dihydroxypropyl)-5-[(hydroxyacetyl)amino]-2,4,6-triiodo-1,3-benzenedicarboxamide;N,N'-bis-(2,3-dihydroxypropyl)-5-(2-hydroxyacetylamino)-2,4,6-triiodoisophthalamide
• CAS NO: 77868-40-7
• Molecular Formula: C₁₆H₂₀I₃N₃O₈
• Molecular Weight: 763.05871
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals;Intermediate of Ioversol
• Mol File: 77868-40-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 784.1±60.0 °C(Predicted)
• Appearance: /
• Density: 2.3670 (rough estimate)
• Refractive Index: 1.7550 (estimate)
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Water
• PKA: 10.57±0.70(Predicted)
• Water Solubility: 17.68g/L(25 oC)
• CAS DataBase Reference: N-DesMethyl IoMeprol(CAS DataBase Reference)
• NIST Chemistry Reference: N-DesMethyl IoMeprol(77868-40-7)
• EPA Substance Registry System: N-DesMethyl IoMeprol(77868-40-7)

Safety Data

• Hazardous Substances Data: 77868-40-7(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

N-Desmethyl Iomeprol is an intermediate used in the preparation of Iomeprol (I730500), and x-ray contrast agent.

Upstream product

• 35453-19-1 2,4,6-triiodo-5-aminoisophthalic acid 
• 37441-29-5 5-amino-2,4,6-triiodoisophthalic acid dichloride 
• 78314-12-2 2-((3,5-bis (chlorocarbonyl)-2,4,6-triiodophenyl)amino)-2-oxoethyl acetate 
• 87785-51-1 5-(acetoxyacetylamino)-N,N'-bis(2,3-diacetoxypropyl)-2,4,6-triiodoisophthalamide 

Downstream Products

• 87771-40-2 ioversol 
• 78649-41-9 iomeprol 

Relevant articles and documents

Process for the Monotopic Preparation of Intermediate Organo-Iodinated Compounds for the Synthesis of Ioversol

The invention relates to a process for the preparation of organo-iodinated compounds as well as the preparation intermediates thereof. More specifically, the invention relates to a process for the preparation of organo-iodinated compounds useful as preparation intermediates in the synthesis of the contrast product ioversol.

New Methods for Preparing an Intermediate of Contrast Medium and Methods for Preparing Contrast Medium

The present invention relates to a method for preparing an intermediate of contrast agent or contrast agent. Also, the manufacturing cost can be significantly reduced. , The manufacturing method of the present invention can greatly reduce the production cost of contrast agents and is suitable for mass production. (by machine translation)