78239-71-1

Basic information

• Product Name: 3-BROMO-4-FLUOROBENZYL BROMIDE
• Synonyms: 2-BroMo-4-(broMoMethyl)-1-fluorobenzene;2-Bromo-4-(bromomethyl)-1-fluorobenzene, alpha,3-Dibromo-4-fluorotoluene
• CAS NO: 78239-71-1
• Molecular Formula: C₇H₅Br₂F
• Molecular Weight: 267.93
• Mol File: 78239-71-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 41 °C
• Boiling Point: 259.8 °C at 760 mmHg
• Flash Point: 110.9 °C
• Appearance: White/Solid
• Density: 1.923 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Methanol
• Water Solubility: Slightly soluble in water.
• Sensitive: Lachrymatory
• CAS DataBase Reference: 3-BROMO-4-FLUOROBENZYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-FLUOROBENZYL BROMIDE(78239-71-1)
• EPA Substance Registry System: 3-BROMO-4-FLUOROBENZYL BROMIDE(78239-71-1)

Safety Data

• Hazard Codes: C,T
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 78239-71-1(Hazardous Substances Data)

Usage

Uses

3-Bromo-4-fluorobenzyl bromide is used as a pharmaceutical intermediate.

InChI:InChI=1S/C7H5Br2F/c8-4-5-1-2-7(10)6(9)3-5/h1-3H,4H2

Upstream product

• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 77771-03-0 3-bromo-4-fluoro-benzyl alcohol 
• 452-62-0 3-bromo-4-fluorotoluene 

Downstream Products

• 14937-93-0 α-(3-Brom-4-fluor-benzyl)-α-acetamino-malonsaeure-diethylester 
• 78239-69-7 3-bromo-4-fluorobenzyl phenyl ether 
• 1068441-44-0 3-(3-bromo-4-fluorobenzyloxy)phenol 
• 880348-40-3 (S)-2-(benzhydrylidene-amino)-3-(3-bromo-4-fluoro-phenyl)-propionic acid tert-butyl ester 
• 501420-63-9 2-(3-bromo-4-fluoro-phenyl)acetonitrile 

Relevant articles and documents

Bromine structural domain inhibitor compound and application thereof

The invention relates to a bromine structural domain inhibitor and provides a compound shown in a general formula I, pharmaceutical salt, an enantiomer, a diastereoisomer, an atropisomer, racemate, apolymorphic substance and solvate of the compound or an isotope labelled compound (including a deuterium substituted compound), a preparation method of the compound, pharmaceutical composition containing the compound and an application of the above components in pharmaceuticals.

OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AND THE USE THEREOF

The present application relates to novel carboxylic acid derivatives having an oxo-substituted azaheterocyclic partial structure, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

BETA-SECRETASE MODULATORS AND METHODS OF USE

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I); wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula (I), methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula (I), or compositions including them, to a subject. The invention also comprises further embodiments of Formulas (II) and (III), intermediates and processes useful for the preparation of compounds of the invention.