78330-02-6

Basic information

• Product Name: ethyl 4-hydroxy-3-(morpholin-4-ylmethyl)benzoate
• CAS NO: 78330-02-6
• Molecular Formula: C₁₄H₁₉NO₄
• Molecular Weight: 265.305
• Mol File: 78330-02-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 407°C at 760 mmHg
• Flash Point: 199.9°C
• Density: 1.207g/cm³
• Vapor Pressure: 3.32E-07mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: ethyl 4-hydroxy-3-(morpholin-4-ylmethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-hydroxy-3-(morpholin-4-ylmethyl)benzoate(78330-02-6)
• EPA Substance Registry System: ethyl 4-hydroxy-3-(morpholin-4-ylmethyl)benzoate(78330-02-6)

Safety Data

• Hazardous Substances Data: 78330-02-6(Hazardous Substances Data)

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 110-91-8 morpholine 
• 50-00-0 formaldehyd 

Relevant articles and documents

Cu(II)-Catalyzed ortho-Selective Aminomethylation of Phenols

A Cu(II)-catalyzed ortho-selective functionalization of free phenols with trifluoroborates to afford Csp2-Csp3 coupling products under mild conditions has been developed. A variety of functional groups on the phenol and the potassium aminomethyltrifluoroborate substrates were found compatible, furnishing the corresponding products in moderate to excellent yields. A single-electron transfer radical coupling mechanism involving a six-membered transition state is proposed to rationalize the high levels of ortho-selectivity in the reaction. This protocol provides straightforward access to ortho-aminomethyl-substituted phenols, unnatural amino acids and other bioactive small molecules.